Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy

PHASE3CompletedINTERVENTIONAL
Enrollment

236

Participants

Timeline

Start Date

September 30, 2009

Primary Completion Date

December 14, 2023

Study Completion Date

September 4, 2025

Conditions
Cervical Cancer
Interventions
DRUG

carboplatin

Intravenously

DRUG

cisplatin

Intravenously

DRUG

paclitaxel

Intravenously

RADIATION

intensity-modulated radiation therapy

Daily fractions

RADIATION

standard external beam radiation therapy

Daily fractions

RADIATION

Optional brachytherapy boost

Low-dose rate (20-25 Gy single application) or high-dose rate (12-18 Gy 2-3 applications), dependent on external beam dose.

Trial Locations (125)

10065

Memorial Sloan-Kettering Cancer Center, New York

10461

Montefiore Medical Center-Weiler Division, The Bronx

11203

State University of New York Downstate Medical Center, Brooklyn

14620

Highland Hospital, Rochester

14642

University of Rochester, Rochester

19026

Delaware County Memorial Hospital, Drexel Hill

19096

Lankenau Hospital, Wynnewood

19611

Reading Hospital, West Reading

20910

Holy Cross Hospital, Silver Spring

21044

Central Maryland Radiation Oncology in Howard County, Columbia

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21204

Greater Baltimore Medical Center, Baltimore

21215

Sinai Hospital of Baltimore, Baltimore

26003

Wheeling Hospital, Wheeling

28203

Carolinas Medical Center, Charlotte

30303

Grady Health System, Atlanta

30342

Northside Hospital, Atlanta

30501

Northeast Georgia Medical Center, Gainesville

31403

Memorial Health University Medical Center, Savannah

31405

Saint Joseph's-Candler Health System, Savannah

32803

Florida Hospital, Orlando

33021

Memorial Healthcare System - Joe DiMaggio Children's Hospital, Hollywood

33136

Jackson Memorial Hospital-Holtz Children's Hospital, Miami

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33176

Baptist Hospital of Miami, Miami

33442

University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35294

University of Alabama at Birmingham, Birmingham

36608

Providence Hospital, Mobile

37920

University of Tennessee - Knoxville, Knoxville

39216

University of Mississippi Medical Center, Jackson

43210

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus

43560

Flower Hospital, Sylvania

43614

University of Toledo, Toledo

44106

Case Western Reserve University, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Orange

44145

UHHS-Westlake Medical Center, Westlake

44203

Summa Barberton Hospital, Barberton

44256

Summa Health Center at Lake Medina, Medina

44266

Robinson Radiation Oncology, Ravenna

44304

Summa Akron City Hospital/Cooper Cancer Center, Akron

44307

Akron General Medical Center, Akron

44460

Cancer Care Center, Incorporated, Salem

44691

Cancer Treatment Center, Wooster

44870

Ireland Cancer Center at Firelands Regional Medical Center, Sandusky

45267

University of Cincinnati, Cincinnati

45662

Southern Ohio Medical Center, Portsmouth

46016

Saint Vincent Anderson Regional Hospital/Cancer Center, Anderson

46107

Saint Francis Hospital and Health Centers, Beech Grove

46237

Franciscan Saint Francis Health-Indianapolis, Indianapolis

46320

Franciscan Saint Margaret Health-Hammond Campus, Hammond

48060

Saint Joseph Mercy Port Huron, Port Huron

48093

Saint John Macomb-Oakland Hospital, Warren

48236

Saint John Hospital and Medical Center, Detroit

49007

West Michigan Cancer Center, Kalamazoo

49221

Hickman Cancer Center, Adrian

50401

Mercy Medical Center - North Iowa, Mason City

52242

University of Iowa Hospitals and Clinics, Iowa City

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Froedtert and the Medical College of Wisconsin, Milwaukee

53227

Aurora West Allis Medical Center, West Allis

54301

Saint Vincent Hospital, Green Bay

55407

Abbott-Northwestern Hospital, Minneapolis

55905

Mayo Clinic, Rochester

57104

Sanford Cancer Center-Oncology Clinic, Sioux Falls

57701

Rapid City Regional Hospital, Rapid City

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

61637

OSF Saint Francis Medical Center, Peoria

63141

Saint John's Mercy Medical Center, St Louis

64064

Kansas City Cancer Center-Lee's Summit, Lee's Summit

64131

Kansas City Cancer Center - South, Kansas City

64154

Kansas City Cancer Centers - North, Kansas City

65401

Phelps County Regional Medical Center, Rolla

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66160

University of Kansas Medical Center, Kansas City

66210

Kansas City Cancer Centers-Southwest, Overland Park

67214

Via Christi Regional Medical Center, Wichita

68114

Nebraska Methodist Hospital, Omaha

68198

The Nebraska Medical Center, Omaha

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75390

University of Texas Southwestern Medical Center, Dallas

77030

M D Anderson Cancer Center, Houston

Methodist Hospital, Houston

80907

Penrose-Saint Francis Healthcare, Colorado Springs

83706

Saint Alphonsus Regional Medical Center, Boise

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

84157

Intermountain Medical Center, Murray

84403

McKay-Dee Hospital Center, Ogden

84770

Dixie Medical Center Regional Cancer Center, St. George

85013

Saint Joseph's Hospital and Medical Center, Phoenix

85381

Arizona Center for Cancer Care-Peoria, Peoria

91010

City of Hope Medical Center, Duarte

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

91767

Pomona Valley Hospital Medical Center, Pomona

92103

University of California At San Diego, San Diego

92868

Saint Joseph Hospital - Orange, Orange

94574

Saint Helena Hospital, St. Helena

95608

Mercy San Juan Medical Center, Carmichael

95816

Mercy Cancer Center, Sacramento

95819

Mercy General Hospital Radiation Oncology Center, Sacramento

96813

Queen's Medical Center, Honolulu

University of Hawaii, Honolulu

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

98109

Seattle Cancer Care Alliance, Seattle

98902

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

99508

Providence Alaska Medical Center, Anchorage

06102

Hartford Hospital, Hartford

06050

The Hospital of Central Connecticut, New Britain

46545-1470

Michiana Hematology Oncology PC-Mishawaka, Mishawaka

03103

Elliot Hospital, Manchester

08103

Cooper Hospital University Medical Center, Camden

07962

Morristown Memorial Hospital, Morristown

08060

Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County, Mount Holly

07103

UMDNJ - New Jersey Medical School, Newark

08043

MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township

10467-2490

Montefiore Medical Center, The Bronx

02905

Women and Infants Hospital, Providence

H2W 1S6

McGill University Department of Oncology, Montreal

Unknown

Pamela Youde Nethersole Eastern Hospital, Chai Wan

463-707

Seoul National University Bundang Hospital, Seongnam

110-744

Seoul National University Hospital, Seoul

135-720

Gangnam Severance Hospital, Seoul

139-706

Korea Cancer Center Hospital, Seoul

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

NRG Oncology

OTHER

lead

Radiation Therapy Oncology Group

NETWORK