Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

349

Participants

Timeline

Start Date

September 14, 2009

Primary Completion Date

January 31, 2015

Study Completion Date

March 6, 2026

Conditions
Endometrial AdenocarcinomaEndometrial Adenosquamous CarcinomaEndometrial Clear Cell AdenocarcinomaEndometrial Serous AdenocarcinomaRecurrent Malignant Uterine Corpus NeoplasmStage IIIA Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 StageStage IIIB Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 StageStage IIIC Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 StageStage IVA Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 StageStage IVB Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage
Interventions
BIOLOGICAL

Bevacizumab

Given IV

DRUG

Carboplatin

Given IV

DRUG

Ixabepilone

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Paclitaxel

Given IV

DRUG

Temsirolimus

Given IV

Trial Locations (230)

10065

Memorial Sloan Kettering Cancer Center, New York

11203

State University of New York Downstate Medical Center, Brooklyn

11365

New York Hospital Medical Center of Queens, Fresh Meadows

11718

Island Gynecologic Oncology, Brightwaters

11794

Stony Brook University Medical Center, Stony Brook

12208

Women's Cancer Care Associates LLC, Albany

14263

Roswell Park Cancer Institute, Buffalo

16801

Geisinger Medical Group, State College

17822

Geisinger Medical Center, Danville

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19001

Jefferson Abington Hospital, Abington

19107

Pennsylvania Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19611

Reading Hospital, West Reading

19718

Christiana Care Health System-Christiana Hospital, Newark

19958

Beebe Medical Center, Lewes

20010

MedStar Washington Hospital Center, Washington D.C.

21204

Greater Baltimore Medical Center, Baltimore

21215

Sinai Hospital of Baltimore, Baltimore

21237

MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore

21921

Christiana Care - Union Hospital, Elkton

22908

University of Virginia Cancer Center, Charlottesville

23298

VCU Massey Comprehensive Cancer Center, Richmond

23502

Virginia Oncology Associates - Norfolk, Norfolk

23666

Virginia Oncology Associates-Hampton, Hampton

24033

Carilion Roanoke Memorial Hospital, Roanoke

27157

Wake Forest University Health Sciences, Winston-Salem

27215

Cone Health Cancer Center at Alamance Regional, Burlington

27710

Duke University Medical Center, Durham

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28204

Novant Health Presbyterian Medical Center, Charlotte

28816

Hope Women's Cancer Centers-Asheville, Asheville

29210

South Carolina Oncology Associates PA, Columbia

29425

Medical University of South Carolina, Charleston

31201

Central Georgia Gynecologic Oncology, Macon

31404

Memorial Health University Medical Center, Savannah

32803

AdventHealth Orlando, Orlando

32806

Orlando Health Cancer Institute, Orlando

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33756

Morton Plant Hospital, Clearwater

37232

Vanderbilt University/Ingram Cancer Center, Nashville

39216

Saint Dominic-Jackson Memorial Hospital, Jackson

University of Mississippi Medical Center, Jackson

39581

Singing River Hospital, Pascagoula

40202

The James Graham Brown Cancer Center at University of Louisville, Louisville

40503

Baptist Health Lexington, Lexington

40536

University of Kentucky/Markey Cancer Center, Lexington

43210

Ohio State University Comprehensive Cancer Center, Columbus

43214

Riverside Methodist Hospital, Columbus

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44109

MetroHealth Medical Center, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44195

Cleveland Clinic Foundation, Cleveland

44304

Summa Health System - Akron Campus, Akron

44307

Cleveland Clinic Akron General, Akron

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45409

Miami Valley Hospital, Dayton

45429

Kettering Medical Center, Kettering

46260

Ascension Saint Vincent Indianapolis Hospital, Indianapolis

46350

IU Health La Porte Hospital, La Porte

46391

Michiana Hematology Oncology PC-Westville, Westville

46514

Michiana Hematology Oncology PC-Elkhart, Elkhart

46515

Elkhart General Hospital, Elkhart

46545

Michiana Hematology Oncology PC-Mishawaka, Mishawaka

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka

46563

Michiana Hematology Oncology PC-Plymouth, Plymouth

46601

Memorial Hospital of South Bend, South Bend

46617

South Bend Clinic, South Bend

46628

Northern Indiana Cancer Research Consortium, South Bend

46904

Community Howard Regional Health, Kokomo

48060

Lake Huron Medical Center, Port Huron

48073

Corewell Health William Beaumont University Hospital, Royal Oak

48093

Henry Ford Health Warren Hospital, Warren

48106

Michigan Cancer Research Consortium NCORP, Ann Arbor

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48124

Corewell Health Dearborn Hospital, Dearborn

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48236

Henry Ford Health Saint John Hospital, Detroit

48341

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

Hurley Medical Center, Flint

48532

Genesys Regional Medical Center-West Flint Campus, Flint

48601

MyMichigan Medical Center Saginaw, Saginaw

48912

University of Michigan Health - Sparrow Lansing, Lansing

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49048

Beacon Kalamazoo, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49201

Allegiance Health, Jackson

50010

McFarland Clinic - Ames, Ames

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Iowa-Wide Oncology Research Coalition NCORP, Des Moines

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54601

Gundersen Lutheran Medical Center, La Crosse

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55905

Mayo Clinic in Rochester, Rochester

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

57105

Avera Cancer Institute, Sioux Falls

60123

Advocate Sherman Hospital, Elgin

60521

Hinsdale Hematology Oncology Associates Incorporated, Hinsdale

Sudarshan K Sharma MD Limited-Gynecologic Oncology, Hinsdale

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

63104

SSM Health Saint Louis University Hospital, St Louis

63110

Washington University School of Medicine, St Louis

65212

MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia

65401

Phelps Health Delbert Day Cancer Institute, Rolla

65804

Cancer Research for the Ozarks NCORP, Springfield

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66160

University of Kansas Cancer Center, Kansas City

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

Wichita NCI Community Oncology Research Program, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

67801

Cancer Center of Kansas - Dodge City, Dodge City

67905

Cancer Center of Kansas-Liberal, Liberal

68114

Nebraska Methodist Hospital, Omaha

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

75235

Parkland Memorial Hospital, Dallas

75390

Clements University Hospital, Dallas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76508

Scott and White Memorial Hospital, Temple

77030

M D Anderson Cancer Center, Houston

80045

UCHealth University of Colorado Hospital, Aurora

80110

Rocky Mountain Gynecologic Oncology PC, Englewood

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

85013

Saint Joseph's Hospital and Medical Center, Phoenix

85259

Mayo Clinic in Arizona, Scottsdale

85719

University of Arizona Cancer Center-North Campus, Tucson

87106

Southwest Gynecologic Oncology Associates Inc, Albuquerque

University of New Mexico Cancer Center, Albuquerque

89106

Women's Cancer Center of Nevada, Las Vegas

89502

Center of Hope at Renown Medical Center, Reno

Renown Regional Medical Center, Reno

90095

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92093

UC San Diego Moores Cancer Center, La Jolla

92103

UC San Diego Medical Center - Hillcrest, San Diego

92161

San Diego VA Medical Center, San Diego

94040

Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View

94115

UCSF Medical Center-Mount Zion, San Francisco

94520

John Muir Medical Center-Concord, Concord

94598

John Muir Medical Center-Walnut Creek, Walnut Creek

96701

Pali Momi Medical Center, ‘Aiea

96766

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96793

Maui Memorial Medical Center, Wailuku

Pacific Cancer Institute of Maui, Wailuku

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

Queen's Cancer Center - Kuakini, Honolulu

The Cancer Center of Hawaii-Liliha, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

98104

Pacific Gynecology Specialists, Seattle

98109

Fred Hutchinson Cancer Center, Seattle

98112

Kaiser Permanente Washington, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98133

University of Washington Medical Center - Northwest, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

98201

Providence Regional Cancer Partnership, Everett

98226

PeaceHealth Medical Group PC, Bellingham

98274

Skagit Regional Health Cancer Care Center, Mount Vernon

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98383

Saint Michael Cancer Center, Silverdale

98384

Olympic Medical Cancer Care Center, Sequim

98405

MultiCare Tacoma General Hospital, Tacoma

Saint Joseph Medical Center, Tacoma

98801

Wenatchee Valley Hospital and Clinics, Wenatchee

99202

Cancer Care Northwest - Spokane South, Spokane

99204

MultiCare Deaconess Cancer and Blood Specialty Center - Downtown, Spokane

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

06102

Hartford Hospital, Hartford

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06050

The Hospital of Central Connecticut, New Britain

06520

Yale University, New Haven

32224-9980

Mayo Clinic in Florida, Jacksonville

46514-2098

Elkhart Clinic, Elkhart

50266-7700

Methodist West Hospital, West Des Moines

04102

MaineHealth Maine Medical Center - Portland, Portland

01199

Baystate Medical Center, Springfield

01605

UMass Memorial Medical Center - Memorial Division, Worcester

08103

Cooper Hospital University Medical Center, Camden

07960

Morristown Medical Center, Morristown

08060

Virtua Memorial, Mount Holly

07101

Rutgers New Jersey Medical School, Newark

08865

Saint Luke's Hospital-Warren Campus, Phillipsburg

07902

Overlook Hospital, Summit

08043

Virtua Voorhees, Voorhees Township

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

02905

Women and Infants Hospital, Providence

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

77555-0565

University of Texas Medical Branch, Galveston

77026-1967

Lyndon Baines Johnson General Hospital, Houston

05401

University of Vermont Medical Center, Burlington

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH

NCT00977574 - Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer | Biotech Hunter | Biotech Hunter