NCT00975052View on ClinicalTrials.gov

A Study of the Effects of Sitagliptin (MK0431) and Metformin on Incretin Hormone Concentrations (0431-050)(COMPLETED)

PHASE1CompletedINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

January 31, 2006

Primary Completion Date

March 31, 2006

Study Completion Date

March 31, 2006

Conditions
Type 2 Diabetes
Interventions
DRUG

sitagliptin phosphate

100 mg sitagliptin daily for two days in one out of four treatment periods

DRUG

Comparator: metformin

500 mg twice daily on Day 1 and 1000 mg once daily on Day 2 in one of four treatment periods.

DRUG

Comparator: sitagliptin and metformin

100 mg sitagliptin once daily and 500 mg metformin twice daily on Day 1 and 100 mg sitagliptin once daily and 1000 mg metformin once daily on Day 2 in one of four treatment periods.

DRUG

Comparator: placebo

Placebo only on Days 1 and 2 in one of four treatment periods.

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT00975052 - A Study of the Effects of Sitagliptin (MK0431) and Metformin on Incretin Hormone Concentrations (0431-050)(COMPLETED) | Biotech Hunter | Biotech Hunter