Vorinostat, Rituximab, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

83

Participants

Timeline

Start Date

November 15, 2010

Primary Completion Date

December 30, 2015

Study Completion Date

March 6, 2026

Conditions
Ann Arbor Stage II Non-Hodgkin LymphomaAnn Arbor Stage III Non-Hodgkin LymphomaAnn Arbor Stage IV Non-Hodgkin Lymphoma
Interventions
DRUG

Cyclophosphamide

Given IV

DRUG

Doxorubicin Hydrochloride

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Prednisone

Given IV

BIOLOGICAL

Rituximab

Given IV

DRUG

Vincristine Sulfate

Given IV

DRUG

Vorinostat

Given PO

Trial Locations (190)

14623

Interlakes Foundation Inc-Rochester, Rochester

14642

University of Rochester, Rochester

14905

Arnot Ogden Medical Center/Falck Cancer Center, Elmira

27104

Southeast Clinical Oncology Research Consortium NCORP, Winston-Salem

27534

Wayne Memorial Hospital, Goldsboro

28677

Iredell Memorial Hospital, Statesville

28791

Margaret R Pardee Memorial Hospital, Hendersonville

28792

AdventHealth Hendersonville, Hendersonville

29303

Spartanburg Medical Center, Spartanburg

29601

Saint Francis Hospital, Greenville

29621

AnMed Health Cancer Center, Anderson

AnMed Health Hospital, Anderson

31404

Memorial Health University Medical Center, Savannah

36608

Providence Hospital, Mobile

43015

Grady Memorial Hospital, Delaware

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

43081

Saint Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

43214

Riverside Methodist Hospital, Columbus

43215

Columbus NCI Community Oncology Research Program, Columbus

Grant Medical Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

43311

Mary Rutan Hospital, Bellefontaine

43701

Genesis Healthcare System Cancer Care Center, Zanesville

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45331

Wayne Hospital, Greenville

45373

Upper Valley Medical Center, Troy

45385

Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

45415

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45433

Wright-Patterson Medical Center, Wright-Patterson Air Force Base

45459

Dayton NCI Community Oncology Research Program, Dayton

45504

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45750

Marietta Memorial Hospital, Marietta

45840

Blanchard Valley Hospital, Findlay

46107

Franciscan Saint Francis Health-Beech Grove, Beech Grove

46237

Franciscan Health Indianapolis, Indianapolis

47374

Reid Health, Richmond

49017

Bronson Battle Creek, Battle Creek

49307

Spectrum Health Big Rapids Hospital, Big Rapids

49444

Trinity Health Muskegon Hospital, Muskegon

49503

Cancer Research Consortium of West Michigan NCORP, Grand Rapids

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

59101

Billings Clinic Cancer Center, Billings

Saint Vincent Healthcare, Billings

59102

Montana Cancer Consortium NCORP, Billings

Saint Vincent Frontier Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59601

Saint Peter's Community Hospital, Helena

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59715

Bozeman Health Deaconess Hospital, Bozeman

59802

Montana Cancer Specialists, Missoula

Saint Patrick Hospital - Community Hospital, Missoula

59901

Glacier Oncology PLLC, Kalispell

Logan Health Medical Center, Kalispell

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60153

Loyola University Medical Center, Maywood

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

62864

SSM Health Good Samaritan, Mount Vernon

63109

Mercy Infusion Center - Chippewa, St Louis

63141

Mercy Hospital Saint Louis, St Louis

64068

Liberty Hospital, Liberty

64086

Saint Luke's East - Lee's Summit, Lee's Summit

64108

University Health Truman Medical Center, Kansas City

64111

Saint Luke's Hospital of Kansas City, Kansas City

64114

Saint Joseph Health Center, Kansas City

64116

North Kansas City Hospital, Kansas City

64118

Heartland Hematology and Oncology Associates Incorporated, Kansas City

64132

Research Medical Center, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

65401

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65804

Cancer Research for the Ozarks NCORP, Springfield

Mercy Hospital Springfield, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66112

Providence Medical Center, Kansas City

66160

University of Kansas Cancer Center, Kansas City

66208

Kansas City NCI Community Oncology Research Program, Prairie Village

66209

Menorah Medical Center, Overland Park

66213

Saint Luke's South Hospital, Overland Park

66606

University of Kansas Health System Saint Francis Campus, Topeka

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

66762

Mercy Hospital Pittsburg, Pittsburg

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

Wichita NCI Community Oncology Research Program, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

Salina Regional Health Center, Salina

67502

Hutchinson Regional Medical Center, Hutchinson

67530

Saint Rose Ambulatory and Surgery Center, Great Bend

67601

HaysMed, Hays

67801

Cancer Center of Kansas - Dodge City, Dodge City

67905

Cancer Center of Kansas-Liberal, Liberal

71052

DeSoto Regional Health System, Mansfield

71101

Overton Brooks Veteran's Administration Medical Center, Shreveport

71103

LSU Health Sciences Center at Shreveport, Shreveport

71105

Highland Clinic, Shreveport

71202

Ochsner LSU Health Monroe Medical Center, Monroe

71301

Christus Saint Frances Cabrini Hospital, Alexandria

72401

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro

NEA Baptist Memorial Hospital, Jonesboro

72903

Mercy Hospital Fort Smith, Fort Smith

80524

Poudre Valley Hospital, Fort Collins

82609

Rocky Mountain Oncology, Casper

82801

Welch Cancer Center, Sheridan

85704

University of Arizona Cancer Center-Orange Grove Campus, Tucson

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

90033

USC / Norris Comprehensive Cancer Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

93720

Kaiser Permanente-Fresno, Fresno

94063

Kaiser Permanente-Redwood City, Redwood City

94080

Kaiser Permanente-South San Francisco, South San Francisco

94115

Kaiser Permanente-San Francisco, San Francisco

94531

Kaiser Permanente-Deer Valley Medical Center, Antioch

94538

Kaiser Permanente-Fremont, Fremont

94577

Kaiser Permanente San Leandro, San Leandro

94589

Kaiser Permanente-Vallejo, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente-Oakland, Oakland

94801

Kaiser Permanente-Richmond, Richmond

94903

Kaiser Permanente-San Rafael, San Rafael

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95210

Kaiser Permanente-Stockton, Stockton

95356

Kaiser Permanente-Modesto, Modesto

95403

Kaiser Permanente-Santa Rosa, Santa Rosa

95661

Kaiser Permanente-Roseville, Roseville

95688

Kaiser Permanente Medical Center-Vacaville, Vacaville

95823

Kaiser Permanente-South Sacramento, Sacramento

95825

Kaiser Permanente Sacramento Medical Center, Sacramento

96701

Pali Momi Medical Center, ‘Aiea

Queen's Cancer Center - Pearlridge, ‘Aiea

96734

Castle Medical Center, Kailua

96766

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

Hawaii Cancer Care Inc-Liliha, Honolulu

Kuakini Medical Center, Honolulu

Queen's Cancer Center - Kuakini, Honolulu

96819

Kaiser Permanente Moanalua Medical Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

96859

Tripler Army Medical Center, Honolulu

97701

Saint Charles Health System, Bend

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Harborview Medical Center, Seattle

Minor and James Medical PLLC, Seattle

98109

Fred Hutchinson Cancer Center, Seattle

98112

Kaiser Permanente Washington, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98166

Highline Medical Center-Main Campus, Burien

98195

University of Washington Medical Center - Montlake, Seattle

98221

Cancer Care Center at Island Hospital, Anacortes

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98274

Skagit Valley Hospital, Mount Vernon

98284

PeaceHealth United General Medical Center, Sedro-Woolley

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98383

Saint Michael Cancer Center, Silverdale

98801

Wenatchee Valley Hospital and Clinics, Wenatchee

99202

Cancer Care Northwest - Spokane South, Spokane

99218

Evergreen Hematology and Oncology PS, Spokane

99336

Kadlec Clinic Hematology and Oncology, Kennewick

06520

Yale University, New Haven

02118

Boston Medical Center, Boston

01805

Lahey Hospital and Medical Center, Burlington

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT00972478 - Vorinostat, Rituximab, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma | Biotech Hunter | Biotech Hunter