34
Participants
Start Date
June 20, 2011
Primary Completion Date
April 23, 2020
Study Completion Date
April 23, 2020
Leukapheresis
"Leukapheresis #1 - For Collecting T Cells~Leukapheresis #2 - For Collecting Stem Cells, month following #1~Blood drawn through vein, passed through a machine to collect specific blood cells, then remaining blood returned, about 3 hours to complete."
Stem Cell Transplant
Stem cell infusion by vein over 30-45 minutes on Day 0
CD19-specific T Cell Infusion
T Cell Infusion (Gene Transfer) by vein over 15-30 minutes sometime between Day +2 through Day +7.
IL-2
Group 2 or 4, IL-2 dose of 0.3 x 10\^6 U/m\^2 injected under skin, once a day for up to 14 days; first dose on day of T cell infusion.
Carmustine
300 mg/m\^2 IV over 1 hour on Day -6
Etoposide
200 mg/m\^2 IV over 3 hours every 12 hours on Days -5 to -2
Cytarabine
200 mg/m\^2 by vein over 1 hour every 12 hours on Days -5 to -2.
Melphalan
140 mg/m\^2 IV over 30 minutes on Day -1
University of Texas MD Anderson Cancer Center, Houston
Collaborators (2)
National Cancer Institute (NCI)
NIH
Alaunos Therapeutics
INDUSTRY
Intrexon Corporation
INDUSTRY
M.D. Anderson Cancer Center
OTHER