BIBW 2992 (Afatinib) Versus Chemotherapy as First Line Treatment in NSCLC With EGFR Mutation

PHASE3CompletedINTERVENTIONAL
Enrollment

345

Participants

Timeline

Start Date

August 14, 2009

Primary Completion Date

February 9, 2012

Study Completion Date

March 16, 2017

Conditions
Carcinoma, Non-Small-Cell LungAdenocarcinoma
Interventions
DRUG

Pemetrexed

Pemetrexed IV given once every 3 weeks for up to 6 cycles

DRUG

BIBW 2992

BIBW 2992 once daily until progression

DRUG

Cisplatin

Cisplatin IV given once every 3 weeks for up to 6 cycles

Trial Locations (133)

27

Clínica Anglo Americana, San Isidro

34

Instituto Nacional de Enfermedades Neoplásicas, Surquillo

100

National Taiwan University Hospital, Taipei

112

Taipe Veterans General Hospital, Taipei

114

Tri-Service General Hospital, Taipei

704

NCKUH, Tainan City

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

833

Chang Gung Memorial Hospital Kaohsiung, Kaohsiung City

1000

Brussels - UNIV St-Pierre, Brussels

1090

Brussels - UNIV UZ Brussel, Jette

1102

St. Luke Medical Centre, Quezon

1140

SMZ Baumgartner Hoehe Otto Wagner Spital, Vienna

1229

Makati Medical Center, Makati City

2050

Lifehouse, Camperdown

2065

Royal North Shore Hospital, St Leonards

2298

Calvary Mater Newcastle Hospital, Waratah

3000

UZ Leuven, Leuven

3065

St. Vincents Hospital (MEL), Fitzroy

3128

Box Hill Hospital, Box Hill

4000

Centre Hospitalier Universitaire de Liège, Liège

4010

KH d. Elisabethinen Linz, Linz

4032

The Prince Charles Hospital, Chermside

4600

Klinikum Wels - Grieskirchen GmbH, Wels

5042

Flinders Medical Centre, Bedford Park

5065

The Burnside War Memorial Hospital, Toorak Gardens

5600

Pusat Perubatan University Kebangsaan Malaysia, Wilayah Persekutuan

6000

Mount Medical Centre, Perth

Perpetual Succour Hospital (Cebu), Cebu City

8000

Szent György Hospital, Szekesfehervar, Székesfehérvár

8900

Zala County Hospital, Zalaegerszeg, Zalaegerszeg

9000

UNIV UZ Gent, Ghent

9700

Markusovszky County Hospital, Szombathely, Szombathely

10400

Ramathibodi Hospital, Bangkok

10990

Hospital Pulau Pinang, Palau Pinang

12200

Universitätsklinikum Benjamin Franklin, Berlin, Berlin

13620

Seoul National University Bundang Hospital, Seongnam

14033

HOP Côte de Nacre, Caen

14623

Interlakes Foundation, Incorporated, Rochester

16070

Kharkiv Regional Clinical Oncology Center, Kharkiv

18103

Lehigh Valley Hospital / Lehigh Valley Health Network, Allentown

26121

Pius-Hospital, Oldenburg, Oldenburg

30625

Medizinische Hochschule Hannover, Hanover

33179

Innovative Medical Research of South Florida, Miami

33305

Chang Gung Memorial Hospital(TaoYuan), Taoyuan District

38700

HOP Nord Michallon, La Tronche

40002

Srinagarind Hospital, Khonkaen

40447

China Medical University Hospital, Taichung

40705

Taichung Veterans General Hospital, Taichung

44805

CTR René Gauducheau, Saint-Herblain

45122

Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH, Essen

48149

Universitätsklinikum Münster, Münster

49102

City Clinical Hospital #4, Dnipropetrovsk State Medical Academy, Dnipropetrovsk

49933

HOP d'Angers, Angers

50200

Maharaj Nakorn Chiang Mai Hospital, Chiang Mai

52100

Ospedale San Donato di Arezzo, Arezzo

55101

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz

58675

Lungenklinik Hemer, Hemer

59100

Az. USL 4 di Prato, Prato

University Malaya Medical Centre, Wilayah Persekutuan

69317

HOP Croix Rousse, Pneumo, Lyon, Lyon

69655

HOP, Pneumo, Villefranche sur Saône, Villefranche-sur-Saône

70072

Crescent City Research Consortiom, Marrero

72703

Highlands Oncology Group, Fayetteville

75248

INS Curie, Paris

78410

South Texas Institute of Cancer, Northwest Cancer Center, Corpus Christi

79031

Lviv State Oncological Regional Treatment & Diagnostic CTR, Lviv

83000

Donetsk Regional Antitumor Centre, Donetsk

83041

HOP - HIA Sainte Anne, Toulon

90110

Songklanagarind Hospital, Songkhla

90640

Clinical Trials and Research Associates Inc, Montebello

97448

HOP Sud-Réunion, Pneumo, Saint Pierre, Saint Pierre - La Réunion

115478

"FSBSI N.N Blokhin Medical Research Center of Oncology", Moscow

197022

First Pavlov State Medical University Saint Petersburg, Saint Petersburg

"SPb SBIH City Clinical Oncological Dispensary", Saint Petersburg

197758

"FSBI N.N. Petrov National Medical Research Center of Oncology of MoH of RF", Saint Petersburg

200535

ONCOLAB SRL, Craiova, Craiova

249020

Medical Radiology Science Centre, Obninsk

400015

"Institutul Oncologic Prof. Dr. Ion Chiricuta", Cluj-Napoca

420029

Republic Clinical Oncology Dispensary, Dept. Chemotherapy, Kazan'

2540364

Instituto Oncológico Limitada Viña del Mar, Reñaca

B8000FJI

Instituto de Medicina Nuclear de Bahía Blanca, Bahía Blanca

C1118AAT

Hospital Alemán, Capital Federal

C1185AAT

Imcaba S.R.L., Capital Federal

C1425AWC

IMAI Research, Capital Federal

C1426ANZ

Instituto Alexander Fleming, Capital Federal

C1426BOR

Hospital Militar Central, Capital Federal

C1430ERF

PALIAR, Capital Federal

S2000KZE

Centro Oncológico de Rosario, Rosario

Unknown

Centro de Pesquisa do Hospital Lifecenter, Belo Horizonte

Instituto Clínico Oncológico del Sur - ICOS, Temuco

Queen Mary Hospital, Hong Kong

Prince of Wales Hospital, Shatin

St James's Hospital, Dublin

Hospital Nacional Guillermo Almenara Irigoyen, La Victoria

29308-014

Centro de Pesquisas Clínicas em Oncología, Cachoeiro de Itapemirim

80530-010

Insituto de Oncologia do Paraná, Curitiba

90610-000

Hospital São Lucas da Pontifícia Universidade Católica, Porto Alegre

04023-900

UNIFESP Departamento de Medicina de Pneumologia, São Paulo

T2N 4N2

Tom Baker Cancer Centre, Calgary

T6G 1Z2

Cross Cancer Institute (University of Alberta), Edmonton

J4V 2H1

Charles LeMoyne Hospital, Greenfield Park

H2L 4M1

Hematologiste et oncologue medical CHUM - Hopital Notre-Dame, Montreal

H2W 1S6

McGill University, Department of Oncology, Montreal

760-0746

Hospital Dirección de Previsión de Carabineros, Los Condes

00189

Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza, Roma

06132

Osp. Silvestrin, Sant'Andrea Delle Fratte (PG)

460-0001

National Hospital Organization Nagoya Medical Center, Aichi, Nagoya

464-8681

Aichi Cancer Center Hospital, Aichi, Nagoya

277-8577

National Cancer Center Hospital East, Chiba, Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center, Ehime, Matsuyama

811-1395

National Hospital Organization Kyushu Cancer Center, Fukuoka, Fukuoka

060-8648

Hokkaido University Hospital, Hokkaido, Sapporo

650-0047

Institute of Biomedical Research and Innovation Hospital, Hyogo, Kobe

920-8641

Kanazawa University Hospital, Ishikawa, Kanazawa

236-0051

Kanagawa Cardiovascular and Respiratory Center, Kanagawa, Yokohama

951-8566

Niigata Cancer Center Hospital, Niigata, Niigata

710-8602

Kurashiki Central Hospital, Okayama, Kurashiki

700-8558

Okayama University Hospital, Okayama, Okayama

589-8511

Kindai University Hospital, Osaka, Osaka-Sayama

534-0021

Osaka City Hospital Organization Osaka City General Hospital, Osaka, Osaka

591-8555

National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka

411-8777

Shizuoka Cancer Center, Shizuoka, Sunto-gun

361-771

Chungbuk National University Hospital, Cheongju-si

519-763

Chonnam National University Hwasun Hospital, Hwasun

138-736

Asan Medical Center, Seoul

682-714

Ulsan University Hospital, Ulsan

EX2 5DW

Royal Devon and Exeter Hospital, Exeter

GU2 7XX

Royal Surrey County Hospital, Guildford

SW3 6JJ

The Royal Marsden Hospital, London

ME16 9QQ

Maidstone Hospital, Kent Oncology Centre, Maidstone

DN15 7BH

Scunthorpe General Hospital, Oncology, Scunthorpe

SM2 5PT

The Royal Marsden Hospital, Sutton

TR1 3LJ

Royal Cornwall Hospital, Truro

Sponsors
All Listed Sponsors
lead

Boehringer Ingelheim

INDUSTRY