Use of Curcumin for Treatment of Intestinal Adenomas in Familial Adenomatous Polyposis (FAP)

Patients will be randomized to curcumin (3 curcumin pills twice a day for 12 months).

Questions about current and past lifestyle, health background, and medications. This will take about 20 minutes.

Three tubes of blood at visits 0, 4 and 12 months.

Flexible sigmoidoscopy at baseline and every 4 months for the length of the study (4 months, 8 months, 12 months and 16 months). We will take 2-4 tissue samples of the colon lining by a pinch biopsy.

Other: Biopsies (Upper endoscopy) Upper endoscopy at baseline and at 12 months. We will take 2-4 tissue samples of the small intestine lining by a pinch biopsy.