92
Participants
Start Date
April 12, 2010
Primary Completion Date
November 30, 2019
Study Completion Date
November 30, 2019
HSV-Tk
Infusion of approximately 1±0.2 x 10\^7 HSV-Tk genetically modified CD3+ cells/Kg between day +21 and day +49 after haploidentical HCT; in absence of immune reconstitution and GvHD further infusions up to 4 will be administered on monthly basis.
T-cell depleted or T-cell replete strategies
Haploidentical HCT with the infusion of CD34+ cells plus a fixed dose of T cells (1 x 10\^4/Kg) or unmanipulated haploidentical stem cell transplantation followed by high-dose cyclophosphamide as part of GvHD prophylaxis
University Hospitals Leuven, Leuven
Charitè; Campus Benjamin Franklin, Berlin
Hôpital Jean Minjoz, Besançon
Medizinische Hochschule Hannover, Hanover
Hospital de Navarra, Pamplona
Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena
Chaim Sheba Medical Center, Tel Litwinsky
George Papanicolaou Hospital, Thessaloniki
Northwestern University Feinberg School of Medicine, Chicago
Washington University Medical School, St Louis
Universitat Tubingen, Tübingen
Medizinische Klinik und Poliklinik, Ulm
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack
Universitair Ziekenhuis, Ghent
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège
Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand
Centre Hospitalier Régional Universitaire de Lille, Lille
Institut Paoli-Calmettes, Marseille
Centre Hospitalier Universitaire de Nantes, Nantes
Hôpital l'Archet, Nice
Hôpital Saint-Antoine, Paris
IUCT Oncopole - Institut Universitaire du Cancer de Toulouse, Toulouse
University Medical Center Hamburg-Eppendorf, Hamburg
Azienda Sanitaria Ospedaliera S.Croce e Carle, Cuneo
Azienda Ospedaliero-Universitaria Policlinico-Vittorio Emanuele, Catania
Azienda Ospedaliera Universitaria Careggi, Florence
Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello, Palermo
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Presidio Molinette, Torino
Ospedale Santa Maria della Misericordia, Udine
Policlinico G. B. Rossi, Azienda ospedaliera universitaria integrata di Verona, Verona
Ospedale San Raffaele, Milan
Santaros Klinikos, Vilnius
Centro Hospitalar Lisboa Norte, E.P.E., Lisbon
Hospital de la Santa Creu i Sant Pau, Barcelona
Instituto Catalán de Oncología, L'Hospitalet de Llobregat
University of Leipzig, Leipzig
Lead Sponsor
AGC Biologics S.p.A.
INDUSTRY