Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial

NACompletedINTERVENTIONAL
Enrollment

2,204

Participants

Timeline

Start Date

November 13, 2009

Primary Completion Date

December 31, 2017

Study Completion Date

December 31, 2017

Conditions
Atrial FibrillationArrhythmia
Interventions
DEVICE

Left atrial ablation

"St. Jude: Livewire TC™ , Therapy™ Dual / Thermocouple, Safire,Therapy Cool Path~Biosense Webster: NAVI-STAR, NAVI-STAR/NAVI-STAR DS, Celsius Braided/Long Tip, NAVI-STAR™ and Celsius™ ThermoCool, NAVI-STAR® RMT, Celsius® RMT, ThermoCool® SF~Medtronic CryoCath LP: Freezor®/Freezor MAX®, Artic Front®, Cardiac Ablation System~Bard: Stinger~Boston Scientific: Blazer II RF/XP, Blazer RPM, Chilli II Cooled, SteeroCath"

DRUG

Rate or Rhythm Control Therapy

"Rate control: Metoprolol 50-100mg, Atenolol 50-100mg, Propranolol 40-80mg, Acebutolol 200-300mg, Carvedilol 6.25-25mg, Diltiazem 180-240mg, Verapamil 180-240mg, Digoxin 0.125-0.25mg~Rhythm control: Propafenone 450-625mg, Flecainide 200-300mg, Sotalol 240-320mg, Dofetilide 500-1000mcg, Amiodarone 200-400mg, Quinidine 600-900mg, Dronedarone 800mg"

Trial Locations (118)

3050

Royal Melbourne Hospital, Parkville

5000

Royal Adelaide Hospital, Adelaide

10016

New York University Langone Medical Center, New York

10032

Columbia University Medical Center, New York

10467

Montefiore Medical Center, The Bronx

12205

Albany Associates in Cardiology, Albany

12808

Charles University, Prague

14021

Clinic of Cardiology IKEM Medical Institute, Prague

15240

V.A. Pittsburgh Healthcare System, Pittsburgh

17033

Penn State University Cardiovascular Center, Hershey

19096

Lankenau Hospital, Wynnewood

19102

Drexel University College of Medicine, Philadelphia

19104

University of Pennsylvania Health System, Philadelphia

20037

George Washington University Medical Faculty Associates, Washington D.C.

20097

Policlinico San Donato Center of Clinical Arrhythmia and Electrophysiology, San Donato Milanese

20099

Asklepios Klinik St. Georg, Hamburg

Policlinico Multimedical Cardiology and Arrhythmia Centre, Milan

20246

Universitares Herrzentrum Hamburg, Hamburg

21100

Ospedale di Circolo e Fondazione Macchi, Varese

21287

Johns Hopkins Hospital, Baltimore

22042

Virginia Hospital Center - Arlington, Falls Church

22291

Asklepios Klinik Barmbek, Hamburg

22908

University of Virginia Health System, Charlottesville

23219

Virginia Commonwealth University Medical Center, Richmond

23507

Sentara Norfolk General Hospital, Norfolk

27157

Wake Forest University Health Sciences, Winston-Salem

27599

University of North Carolina at Chapel Hill, Chapel Hill

27705

Duke University Medical Center, Durham

28203

The Sanger Clinic, PA, Charlotte

29605

Greenville Hospital System University Medical Center, Greenville

30912

Georgia Regents University, Augusta

31201

Georgia Arrhythmia Consultants & Research Institute, Macon

32308

Tallahassee Memorial Hospital, Tallahassee

32803

Florida Hospital, Orlando

33606

Florida Heart Rhythm-University of South Florida College of Medicine, Tampa

33709

Northside Hospital and Heart Institute, St. Petersburg

37075

Georg-August-University, Göttingen

37232

Vanderbilt University Medical Center, Nashville

37404

Memorial Health Care System, Chattanooga

39216

Jackson Heart Clinic, Jackson

43210

Ohio State University Medical Center, Columbus

44193

Cleveland Clinic Foundation, Cleveland

45267

University of Cincinnati Medical Center, Cincinnati

48197

Saint Joseph Mercy Hospital, Ypsilanti

48202

Henry Ford Hospital, Detroit

50226

Mercy Medical Center-Iowa Heart Center, West Des Moines

53188

Waukesha Memorial Hospital, Waukesha

55417

Minneapolis V.A. Medical Center, Minneapolis

55426

Park Nicollet Methodist Hospital, Saint Louis Park

55905

Mayo Clinic Rochester, Rochester

60010

Alexian Brothers Medical Center, Barrington

60153

Loyola University Medical Center, Maywood

60201

NorthShore University Health System, Evanston

60431

CCB - Cardioaniologisches Centrum Bethanien, Frankfurt

60612

University of Miami Hospital, Miami

Rush University Medical Center, Chicago

63131

Saint John's Mercy Heart Health Center, St Louis

63136

Saint Louis Heart and Vascular, St Louis

65691

Saint Anne's University Hospital, ICRC, Brno

68167

University Hospital of Mannheim, Mannheim

72205

Arkansas Cardiology, PA, Little Rock

74104

Oklahoma Heart Institute, Tulsa

75093

The Heart Hospital Baylor Plano, Plano

75226

Baylor Heart and Vascular Hospital, Dallas

76104

Baylor All Saints Medical Center, Fort Worth

76137

Saint Vincentius-Kliniken, Karlsruhe

76508

Scott and White Memorial Hospital, Temple

77030

University of Texas Health Science Center, Houston

78299

South Texas Cardiovascular Consultants, San Antonio

78705

Texas Cardiac Arrhythmia, Austin

80012

The Medical Center of Aurora, Aurora

80907

Penrose Saint Francis Health Services, Colorado Springs

84143

Intermountain Medical Center-LDS Hospital, Salt Lake City

90017

Good Samaritan Hospital, Los Angeles

90095

University of California Los Angeles, Los Angeles

94143

University of California at San Francisco Medical Center, San Francisco

94305

Stanford University Medical Center, Stanford

95817

University of California Davis Medical Center, Sacramento

96450

Klinikum Coburg, Coburg

97201

Oregon Health and Science University, Portland

97225

Providence Saint Vincent Medical Center, Portland

98122

Swedish Medical Center - Providence Campus, Seattle

98195

University of Washington Medical Center, Seattle

98405

Cardiac Study Center, Tacoma

100029

Beijing Anzhen Hospital, Beijing

100037

Fuwai Hospital, Beijing

115682

Clinical Hospital # 83 under the Federal Medical and Biological Agency, Moscow

116011

First Affiliated Hospital of Dalian Medical University, Dalian

121552

Bakoulev Scientific Center for Cardiovascular Surgery, Moscow

210029

First Affiliated Hospital of Nanjing Medical University, Nanjing

510080

Guangdong Provincial People's Hospital, Guangzhou

630055

Research Institute of Circulation of Pathology, Novosibirsk

634012

Scientific Research Institute of Cardiology of Ministry of Health of Russian Foundation, Tomsk

06115

Hartford Hospital, Hartford

02114

Massachusetts General Hospital, Boston

02115

Brigham and Womens Hospital, Boston

08103

Cooper University Hospital, Camden

07601

Hackensack University Medical Center, Hackensack

08901

Robert Wood Johnson University Hospital, New Brunswick

11794-8167

Stony Brook University Hospital and Medical Center, Stony Brook

17822-2160

Geisinger Wyoming Valley Medical Center, Danville

T2N 2T9

University of Calgary, Calgary

L8L 2X2

Hamilton Health Sciences, Hamilton

N6A 5A5

University of Western Ontario - London Health Sciences Centre, London

L3Y 8C3

Southlake Regional Health Centre, Newmarket

150 30

Na Homolce Hospital, Prague

D-32545

Herz-und Diabeteszentrum NRW, Bad Oeynhausen

D-01307

Technische Universitat Dresden, Dresden

D-61231

Kerckhoff Klinik, Bad Nauheim

01324

Praxisklinik Herz and GefaBe, Dresden

04289

Herzzentrum Leipzig, Leipzig

D-18057

Universitat Rostock, Rostock

Unknown

Korea University Anam Hospital, Seoul

Yonsei University Severance Hospital, Seoul

G81 4HX

Golden Jubilee Hospital, Glasgow

EC1A 7BE

Saint Bartholomew's Hospital, London

SW17 0QT

Saint George's Hospital Medical School, London

W2 1NY

Saint Mary's Hospital, London

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

Abbott Medical Devices

INDUSTRY

collaborator

Biosense Webster, Inc.

INDUSTRY

lead

Mayo Clinic

OTHER