9
Participants
Start Date
May 31, 2006
Primary Completion Date
January 31, 2008
Study Completion Date
January 31, 2008
Diazoxide
Diazoxide will be initiated at half the dose (100 mg per day) for 2 weeks to allow the insulin sensitizing action of metformin to take effect. Dosage will be increased to 200mg daily, divided twice daily with meals for 6 months.
Metformin
Metformin will be initiated at 500 mg twice daily and increased to 1000 mg twice daily over a one week period to minimize gastrointestinal side effects. the 2000mg is to be taken with meals for 6 months.
The Hospital for Sick Children, Toronto
The Hospital for Sick Children
OTHER