Temozolomide and Radiation Therapy With or Without Bevacizumab in Treating Patients With Newly Diagnosed Glioblastoma

PHASE3CompletedINTERVENTIONAL
Enrollment

637

Participants

Timeline

Start Date

April 15, 2009

Primary Completion Date

March 17, 2013

Study Completion Date

March 17, 2013

Conditions
GlioblastomaGliosarcomaSupratentorial Glioblastoma
Interventions
RADIATION

3-Dimensional Conformal Radiation Therapy

Undergo 3-dimentional conformal radiation therapy

BIOLOGICAL

Bevacizumab

Given IV

RADIATION

Intensity-Modulated Radiation Therapy

Undergo intensity-modulated radiation therapy

OTHER

Laboratory Biomarker Analysis

Correlative studies

OTHER

Placebo

Given IV

OTHER

Quality-of-Life Assessment

Ancillary studies

DRUG

Temozolomide

Given orally

Trial Locations (330)

10065

Memorial Sloan-Kettering Cancer Center, New York

11219

Maimonides Medical Center, Brooklyn

11572

South Nassau Communities, Oceanside

11794

Stony Brook University Medical Center, Stony Brook

12206

New York Oncology Hematology PC - Albany, Albany

12601

Hudson Valley Oncology Associates, Poughkeepsie

13210

State University of New York Upstate Medical University, Syracuse

14424

Sands Cancer Center, Canandaigua

14620

Highland Hospital, Rochester

14626

University Radiation Oncology, Rochester

14642

University of Rochester, Rochester

15009

UPMC-Heritage Valley Health System Beaver, Beaver

15065

Allegheny Valley Hospital, Natrona Heights

15132

UPMC Cancer Center at UPMC McKeesport, McKeesport

15146

Intercommunity Cancer Center, Monroeville

15212

Allegheny General Hospital, Pittsburgh

15232

UPMC-Shadyside Hospital, Pittsburgh

15236

UPMC Jefferson Regional Radiation Oncology, Pittsburgh

15237

UPMC-Passavant Hospital, Pittsburgh

15301

UPMC Washington Hospital Radiation Oncology, Washington

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

15901

UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown

16105

UPMC Jameson, New Castle

16201

Armstrong Center for Medicine and Health, Kittanning

16346

UPMC Cancer Center at UPMC Northwest, Seneca

16505

The Regional Cancer Center, Erie

17325

Adams Cancer Center, Gettysburg

17331

Cherry Tree Cancer Center, Hanover

17403

WellSpan Health-York Hospital, York

17604

Lancaster General Hospital, Lancaster

17822

Geisinger Medical Center, Danville

18015

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18301

Pocono Medical Center, East Stroudsburg

18512

Northeast Radiation Oncology Center, Dunmore

18925

Fox Chase Cancer Center Buckingham, Furlong

19001

Abington Memorial Hospital, Abington

19010

Bryn Mawr Hospital, Bryn Mawr

19096

Lankenau Medical Center, Wynnewood

19107

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19114

Aria Health-Torresdale Campus, Philadelphia

19301

Paoli Memorial Hospital, Paoli

19611

Reading Hospital, West Reading

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21229

Saint Agnes Hospital, Baltimore

21401

Anne Arundel Medical Center, Annapolis

22304

Inova Alexandria Hospital, Alexandria

23507

Sentara Norfolk General Hospital, Norfolk

26003

Wheeling Hospital/Schiffler Cancer Center, Wheeling

27103

Novant Health Forsyth Medical Center, Winston-Salem

27104

Southeast Clinical Oncology Research (SCOR) Consortium NCORP, Winston-Salem

27607

Duke Women's Cancer Care Raleigh, Raleigh

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28204

Novant Health Presbyterian Medical Center, Charlotte

28374

FirstHealth of the Carolinas-Moore Regional Hosiptal, Pinehurst

28791

Margaret R Pardee Memorial Hospital, Hendersonville

28801

Mission Hospital-Memorial Campus, Asheville

29303

Spartanburg Medical Center, Spartanburg

30033

Dekalb Medical Center, Decatur

30274

Southern Regional Medical Center, Riverdale

30309

Piedmont Hospital, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30501

Northeast Georgia Medical Center-Gainesville, Gainesville

31404

Memorial University Medical Center, Savannah

31904

John B Amos Cancer Center, Columbus

32073

21st Century Oncology-Orange Park, Orange Park

32086

Integrated Community Oncology Network-Flager Cancer Center, Saint Augustine

32177

21st Century Oncology-Palatka, Palatka

32207

Baptist MD Anderson Cancer Center, Jacksonville

Integrated Community Oncology Network-Southside Cancer Center, Jacksonville

32250

Integrated Community Oncology Network-Florida Cancer Center Beaches, Jacksonville Beach

32258

Baptist Medical Center South, Jacksonville

32504

Sacred Heart Hospital, Pensacola

32803

Florida Hospital Orlando, Orlando

32806

UF Cancer Center at Orlando Health, Orlando

33021

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33140

Mount Sinai Medical Center, Miami Beach

33176

Baptist Hospital of Miami, Miami

33316

Broward Health Medical Center, Fort Lauderdale

34994

Robert and Carol Weissman Cancer Center at Martin Health, Stuart

36608

Providence Hospital, Mobile

37403

Erlanger Medical Center, Chattanooga

37916

Thompson Cancer Survival Center, Knoxville

38301

Jackson-Madison County General Hospital, Jackson

39581

Singing River Hospital, Pascagoula

40202

The James Graham Brown Cancer Center at University of Louisville, Louisville

43210

Ohio State University Comprehensive Cancer Center, Columbus

43214

Riverside Methodist Hospital, Columbus

43215

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43537

Toledo Clinic Cancer Centers-Maumee, Maumee

43560

Flower Hospital, Sylvania

43616

Saint Charles Hospital, Oregon

43623

Mercy Saint Anne Hospital, Toledo

43952

Trinity's Tony Teramana Cancer Center, Steubenville

44060

Lake University Ireland Cancer Center, Mentor

44106

Case Western Reserve University, Cleveland

44109

MetroHealth Medical Center, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44130

Southwest General Health Center Ireland Cancer Center, Middleburg Heights

44145

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44203

Summa Barberton Hospital, Barberton

44304

Summa Akron City Hospital/Cooper Cancer Center, Akron

44307

Akron General Medical Center, Akron

44460

Cancer Care Center, Incorporated, Salem

44708

Mercy Medical Center, Canton

44710

Aultman Health Foundation, Canton

44870

North Coast Cancer Care, Sandusky

45069

University Pointe, West Chester

45219

University of Cincinnati/Barrett Cancer Center, Cincinnati

46202

IU Health Methodist Hospital, Indianapolis

46219

Community Cancer Center East, Indianapolis

IU Health Central Indiana Cancer Centers-East, Indianapolis

46256

Community Cancer Center North, Indianapolis

46260

Saint Vincent Hospital and Health Care Center, Indianapolis

46628

Northern Indiana Cancer Research Consortium, South Bend

46804

Radiation Oncology Associates PC, Fort Wayne

46805

Parkview Hospital Randallia, Fort Wayne

47303

IU Health Ball Memorial Hospital, Muncie

47403

IU Health Bloomington, Bloomington

48073

William Beaumont Hospital-Royal Oak, Royal Oak

48093

Saint John Macomb-Oakland Hospital, Warren

48106

Saint Joseph Mercy Hospital, Ann Arbor

48124

Beaumont Hospital-Dearborn, Dearborn

48236

Saint John Hospital and Medical Center, Detroit

48532

Genesys Regional Medical Center-West Flint Campus, Flint

48601

Saint Mary's of Michigan, Saginaw

48912

Sparrow Hospital, Lansing

49007

West Michigan Cancer Center, Kalamazoo

50010

McFarland Clinic PC-William R Bliss Cancer Center, Ames

50309

Iowa Methodist Medical Center, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

50401

Mercy Medical Center - North Iowa, Mason City

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

52402

Physicians' Clinic of Iowa PC, Cedar Rapids

53038

UW Cancer Center Johnson Creek, Johnson Creek

53188

ProHealth Waukesha Memorial Hospital, Waukesha

53226

Froedtert and the Medical College of Wisconsin, Milwaukee

53717

Dean Hematology and Oncology Clinic, Madison

53792

University of Wisconsin Hospital and Clinics, Madison

54143

Bay Area Medical Center, Marinette

54301

Bellin Memorial Hospital, Green Bay

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54401

Aspirus Regional Cancer Center, Wausau

54409

Langlade Hospital and Cancer Center, Antigo

54449

Marshfield Clinic, Marshfield

Marshfield Medical Center, Marshfield

54476

Diagnostic and Treatment Center, Weston

Marshfield Clinic - Weston Center, Weston

54481

Saint Michael's Hospital, Stevens Point

54494

Aspirus UW Cancer Center, Wisconsin Rapids

54548

Marshfield Clinic-Minocqua Center, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire

Sacred Heart Hospital, Eau Claire

54911

Radiology Associates of Appleton/ThedaCare Regional Medical Center, Appleton

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

55337

Fairview Ridges Hospital, Burnsville

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55433

Mercy Hospital, Coon Rapids

55805

Saint Luke's Hospital of Duluth, Duluth

55905

Mayo Clinic, Rochester

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

56601

Sanford Clinic North-Bemidgi, Bemidji

57104

Sanford Cancer Center-Oncology Clinic, Sioux Falls

57701

Rapid City Regional Hospital, Rapid City

58122

Sanford Broadway Medical Center, Fargo

59101

Billings Clinic Cancer Center, Billings

60005

Northwest Community Hospital, Arlington Heights

60068

Advocate Lutheran General Hospital, Park Ridge

60153

Loyola University Medical Center, Maywood

60426

Ingalls Memorial Hospital, Harvey

60540

Edward Hospital/Cancer Center, Naperville

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61265

Trinity Medical Center, Moline

61603

Methodist Medical Center of Illinois, Peoria

62526

Decatur Memorial Hospital, Decatur

62781

Memorial Medical Center, Springfield

63110

Washington University School of Medicine, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63703

Cape Radiation Oncology, Cape Girardeau

64108

Truman Medical Center, Kansas City

64131

The University of Kansas Cancer Center-South, Kansas City

64154

The University of Kansas Cancer Center-North, Kansas City

64239

Tel Aviv Sourasky Medical Center, Tel Aviv

66160

University of Kansas Cancer Center, Kansas City

66208

Kansas City NCI Community Oncology Research Program, Prairie Village

66210

University of Kansas Cancer Center-Overland Park, Overland Park

67214

Via Christi Regional Medical Center, Wichita

Wesley Medical Center, Wichita

68114

Nebraska Methodist Hospital, Omaha

68122

Alegent Health Immanuel Medical Center, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68198

University of Nebraska Medical Center, Omaha

68510

Saint Elizabeth Regional Medical Center, Lincoln

68847

CHI Health Good Samaritan, Kearney

70121

Ochsner Medical Center Jefferson, New Orleans

70809

Mary Bird Perkins Cancer Center, Baton Rouge

71103

Louisiana State University Health Sciences Center Shreveport, Shreveport

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74136

Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa

75090

Texas Cancer Center-Sherman, Sherman

75237

Texas Oncology Methodist Charlton Cancer Center, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

75601

Texas Oncology-Longview Cancer Center, Longview

75702

Tyler Cancer Center, Tyler

76014

Texas Oncology-Arlington South, Arlington

76022

Texas Oncology Bedford, Bedford

76104

The Klabzuba Cancer Center, Fort Worth

76210

Texas Oncology-Denton South, Denton

77030

M D Anderson Cancer Center, Houston

77479

Texas Oncology Cancer Center Sugar Land, Sugar Land

77802

Saint Joseph Regional Cancer Center, Bryan

78229

University of Texas Health Science Center at San Antonio, San Antonio

79410

Covenant Medical Center-Lakeside, Lubbock

79761

West Texas Cancer Center, Odessa

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

80033

SCL Health Lutheran Medical Center, Wheat Ridge

80113

Swedish Medical Center, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80210

Porter Adventist Hospital, Denver

80229

North Suburban Medical Center, Thornton

80301

Boulder Community Hospital, Boulder

80524

Poudre Valley Hospital, Fort Collins

80907

Penrose-Saint Francis Healthcare, Colorado Springs

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

84143

LDS Hospital, Salt Lake City

84403

McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center, Provo

84770

Dixie Medical Center Regional Cancer Center, St. George

85259

Mayo Clinic in Arizona, Scottsdale

85260

Arizona Oncology Services Foundation, Scottsdale

85704

Arizona Oncology Associates-West Orange Grove, Tucson

87102

Lovelace Medical Center-Downtown, Albuquerque

University of New Mexico Cancer Center, Albuquerque

87109

New Mexico Oncology Hematology Consultants, Albuquerque

89106

Nevada Cancer Research Foundation CCOP, Las Vegas

89502

Renown Regional Medical Center, Reno

90033

USC / Norris Comprehensive Cancer Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

91767

Pomona Valley Hospital Medical Center, Pomona

92093

UC San Diego Moores Cancer Center, La Jolla

92103

University of California San Diego, San Diego

92835

Saint Jude Medical Center, Fullerton

92868

Saint Joseph Hospital - Orange, Orange

93720

California Cancer Center - North Fresno, Fresno

Cancer Care Associates of Fresno Medical Group Inc, Fresno

94080

Kaiser Permanente Cancer Treatment Center, South San Francisco

94115

California Pacific Medical Center-Pacific Campus, San Francisco

94520

John Muir Medical Center-Concord Campus, Concord

94598

John Muir Medical Center-Walnut Creek, Walnut Creek

94609

Bay Area Tumor Institute, Oakland

94611

Kaiser Permanente Oakland-Broadway, Oakland

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

94928

Rohnert Park Cancer Center, Rohnert Park

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95355

Memorial Medical Center, Modesto

95603

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn

95608

Mercy San Juan Medical Center, Carmichael

95661

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

95670

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95682

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park

95687

Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville

95816

Sutter Medical Center Sacramento, Sacramento

95819

Mercy General Hospital Radiation Oncology Center, Sacramento

95823

South Sacramento Cancer Center, Sacramento

96813

University of Hawaii Cancer Center, Honolulu

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97301

Salem Hospital, Salem

97401

Willamette Valley Cancer Center, Eugene

98101

Virginia Mason Medical Center, Seattle

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98310

Harrison Medical Center, Bremerton

98664

PeaceHealth Southwest Medical Center, Vancouver

98684

Compass Oncology Vancouver, Vancouver

98902

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

99202

Cancer Care Northwest - Spokane South, Spokane

99508

Providence Alaska Medical Center, Anchorage

06606

Saint Vincent's Medical Center, Bridgeport

06102

Hartford Hospital, Hartford

06050

The Hospital of Central Connecticut, New Britain

06520

Yale University, New Haven

06360

William Backus Hospital, Norwich

32224-9980

Mayo Clinic in Florida, Jacksonville

04240

Central Maine Medical Center, Lewiston

04074

Maine Medical Center- Scarborough Campus, Scarborough

02114

Massachusetts General Hospital Cancer Center, Boston

02721

Saint Anne's Hospital, Fall River

02601

Cape Cod Hospital, Hyannis

01854

Lowell General Hospital, Lowell

01107

D'Amour Center for Cancer Care, Springfield

03301

Concord Hospital, Concord

03756

Dartmouth Hitchcock Medical Center, Lebanon

03103

Elliot Hospital, Manchester

07039

Saint Barnabas Medical Center, Livingston

07740

Monmouth Medical Center, Long Branch

08903

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick

07701

Riverview Medical Center/Booker Cancer Center, Red Bank

07871

Sparta Cancer Treatment Center, Sparta

10467-2490

Montefiore Medical Center - Moses Campus, The Bronx

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

02903

Rhode Island Hospital, Providence

77555-0565

University of Texas Medical Branch, Galveston

05401

University of Vermont Medical Center, Burlington

23708-2197

Naval Medical Center - Portsmouth, Portsmouth

98122-4307

Swedish Medical Center-First Hill, Seattle

A1B 3V6

Doctor H. Bliss Murphy Cancer Centre, St. John's

P3E 5J1

Health Sciences North, Greater Sudbury

H2L 4M1

CHUM - Hopital Notre-Dame, Montreal

H2W 1S6

McGill University Department of Oncology, Montreal

S4T 7T1

Allan Blair Cancer Centre, Regina

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Radiation Therapy Oncology Group

NETWORK

collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH

NCT00884741 - Temozolomide and Radiation Therapy With or Without Bevacizumab in Treating Patients With Newly Diagnosed Glioblastoma | Biotech Hunter | Biotech Hunter