1,000
Participants
Start Date
December 31, 2007
Primary Completion Date
March 31, 2011
Study Completion Date
May 31, 2011
Minimal (Trophic) Feeding
Upon admission to the ICU, enteral feeds will be started at 10 cc per hour and continued at this rate for 144 hours. After 144 hours of trophic enteral feeds, the feeding rate will be advanced to full-calorie rates, which will continue for the duration of mechanical ventilation up to Day 28.
Full Feeding
Upon admission to the ICU, a full-calorie feeding rate will be determined, which will be calculated to deliver 25 to 35 kcal/kg predicted body weight (PBW) each day. Enteral feeds will be initiated at 25 cc per hour. The feeding rate will be increased by 25 cc per hour every 6 hours until goal rate is achieved, which will be administered for the duration of mechanical ventilation up to Day 28.
University of San Francisco-Fresno Medical Center, Fresno
University of California, Davis Medical Center, Sacramento
University of California, San Francisco (UCSF)-Moffitt Hospital, San Francisco
Centura St. Anthony Central Hospital, Denver
Denver Health Medical Center, Denver
Rose Medical Center, Denver
University of Colorado Health Sciences Center, Denver
Washington Hospital Center, Washington D.C.
Baton Rouge General Hospital-Blue Bonnet, Baton Rouge
Baton Rouge General Hospital-Midcity, Baton Rouge
Earl K. Long Medical Center, Baton Rouge
Our Lady of the Lake Regional Medical Center, Baton Rouge
Medical Center of Louisiana, New Orleans
Ochsner Clinic Foundation, New Orleans
Tulane University Health Sciences Center, New Orleans
Johns Hopkins Bayview Medical Center, Baltimore
Johns Hopkins Hospital, Baltimore
Union Memorial Hospital, Baltimore
University of Maryland Shock Trauma Center, Baltimore
Baystate Medical Center, Springfield
Rochester Methodist Hospital, Rochester
St. Mary's Hospital, Mayo Clinic, Rochester
Duke University Medical Center, Durham
Durham Regional Medical Center, Durham
Moses Cone Health System, Greensboro
Wesley Long Community Hospital, Greensboro
Wake Forest University Baptist Medical Center, Winston-Salem
Cleveland Clinic Foundation, Cleveland
MetroHealth Medical Center, Cleveland
University Hospitals of Cleveland, Cleveland
Vanderbilt University Medical Center, Nashville
Baylor College of Medicine, Houston
Intermountain Medical Center, Murray
McKay-Dee Hospital, Ogden
Utah Valley Regional Medical Center, Provo
LDS Hospital, Salt Lake City
University of Virginia Medical Center, Charlottesville
Harborview Medical Center, Seattle
University of Washington, Seattle
National Heart, Lung, and Blood Institute (NHLBI)
NIH