Routine Versus Aggressive Upstream Rhythm Control for Prevention of Early Atrial Fibrillation in Heart Failure

NACompletedINTERVENTIONAL
Enrollment

250

Participants

Timeline

Start Date

May 4, 2009

Primary Completion Date

February 1, 2018

Study Completion Date

January 31, 2021

Conditions
Atrial Fibrillation
Interventions
OTHER

Upstream therapy

Aldosterone receptor antagonists and statins, dietary restrictions, counseling, and cardiac rehabilitation.

OTHER

Conventional rhythm control

Usual care for atrial fibrillation and heart failure according to the present guidelines

Trial Locations (20)

Unknown

Ziekenhuisgroep Twente, Almelo

Onze Lieve Vrouwe Gasthuis, Amsterdam

Hospital Rijnstate, Arnhem

Ter Gooi Hospital, Blaricum

Amhia Hospital, Breda

Ommelander Hospital Group, Delfzijl

Deventer Hospital, Deventer

Oosterscheldeziekenhuis, Goes

Martini Hospital, Groningen

University Medical Center Groningen, Groningen

Kennemer Gasthuis, Haarlem

Medical University Center Maastricht, Maastricht

University Medical Center Nijmegen, Nijmegen

Viecuri Hospital, Venlo

Ommelander Hospital Group, Winschoten

City Hospital (Sandwell and West Birmingham Hospitals NHS Trust), Birmingham

University Hospitals Birmingham NHS Foundation Trust, Birmingham

Leeds Teaching Hospitals NHS Trust, Leeds

Poole Hospital NHS Foundation Trust, Poole

Good Hope Hospital (Heart of England NHS Foundation Trust), Sutton Coldfield

All Listed Sponsors
collaborator

The Interuniversity Cardiology Institute of the Netherlands

OTHER_GOV

collaborator

Netherlands Heart Foundation

OTHER

collaborator

Dutch Network for Cardiovascular Research

UNKNOWN

collaborator

Trial Coordination Center UMC Groningen

UNKNOWN

collaborator

Bayer

INDUSTRY

collaborator

Boehringer Ingelheim

INDUSTRY

collaborator

Medtronic

INDUSTRY

collaborator

Biotronik SE & Co. KG

INDUSTRY

collaborator

Abbott Medical Devices

INDUSTRY

collaborator

Boston Scientific Corporation

INDUSTRY

collaborator

AstraZeneca

INDUSTRY

lead

I.C. Van Gelder

OTHER