Strategic Timing of Antiretroviral Treatment

PHASE4CompletedINTERVENTIONAL
Enrollment

4,688

Participants

Timeline

Start Date

April 15, 2009

Primary Completion Date

July 27, 2022

Study Completion Date

July 27, 2022

Conditions
HIV Infection
Interventions
DRUG

All licensed antiretroviral medications

In both arms, participants may be prescribed any licensed antiretroviral medication, in accordance with national treatment guidelines. The nature of the intervention is the timing of when to begin treatment with these medications, as described in the two treatment arms.

Trial Locations (218)

11

Hospital Nacional Edgardo Rebagliati Martins, Lima

13

Hospital Nacional Guillermo Almenara Irigoyen, Lima

32

Asociacion Civil Impacta Salud y Educacion - Sede San Miguel, Lima

2010

East Sydney Doctors, Darlinghurst

Holdsworth House Medical Practice, Darlinghurst

St. Vincent's Hospital, Darlinghurst

Taylor Square Private Clinic, Darlinghurst

2134

Burwood Road General Practice, Burwood

2145

Westmead Hospital, Westmead

3004

The Alfred Hospital, Melbourne

3053

Melbourne Sexual Health Centre, Melbourne

3181

Prahran Market Clinic, Melbourne

3182

Centre Clinic, St Kilda

4000

Sexual Health and HIV Service - Clinic 2, Brisbane

5000

Royal Adelaide Hospital, Adelaide

6000

Royal Perth Hospital, Perth

10010

Cornell CRS, New York

10330

Chulalongkorn University Hospital, Bangkok

10400

Ramathibodi Hospital, Bangkok

10457

Bronx-Lebanon Hospital Center, The Bronx

10467

Montefiore Medical Center, The Bronx

10700

Siriraj Hospital, Bangkok Noi

11000

Bamrasnaradura Institute, Nonthaburi

19140

Temple University, Philadelphia

20000

Chonburi Regional Hospital, Chon Buri

20007

Georgetown University, Washington D.C.

20037

George Washington Medical Faculty Associates, Washington D.C.

20360

University Hospital Centre Ibn Rochd, Casablanca

20422

Washington DC VA Medical Center, Washington D.C.

20892

National Institutes of Health Clinical Center, Bethesda

23298

Virginia Commonwealth University, Richmond

23708

Naval Medical Center Portsmouth, Portsmouth

27514

UNC AIDS Clinical Trials Unit, Chapel Hill

27610

Wake County Human Services, Raleigh

27710

Duke University, Durham

32209

University of Florida Health Services Center, Jacksonville

University of Florida, Jacksonville, Jacksonville

32503

Infectious Diseases Associates NW FL, PA, Pensacola

32803

Orlando Immunology Center, Orlando

32805

Florida Department of Health in Orange County/Sunshine Care Center, Orlando

32960

AIDS Research and Treatment Center of the Treasure Coast, Vero Beach

33136

University of Miami, Miami

33602

Hillsborough County Health Deptment/University of South Florida, Tampa

40002

Khon Kaen University, Srinagarind Hospital, Khon Kaen

43210

The Ohio State University Medical Center, Columbus

48075

Newland Immunology Center of Excellence (NICE), Southfield

48201

Wayne State University, Detroit

48202

Henry Ford Health System, Detroit

50120

Sanpatong Hospital, Chiang Mai

50200

Research Institute for Health Sciences (RIHES), Chiang Mai

53203

AIDS Resource Center of Wisconsin, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

55415

Hennepin County Medical Center, Minneapolis

55905

Mayo Clinic, Rochester

57000

Chiangrai Prachanukroh Hospital, Chiang Rai

60608

Mt. Sinai Hospital, Chicago

60612

University of Illinois at Chicago, Chicago

70112

Tulane University Medical Center, New Orleans

75235

UT Southwestern Clinical Research Unit, Dallas

76107

University of North Texas Health Science Center, Fort Worth

77030

Houston AIDS Research Team, Houston

Texas Children's Hospital, Houston

78234

San Antonio Military Health System, San Antonio

80204

Denver Public Health, Denver

90073

VA Greater Los Angeles Healthcare System, Los Angeles

90095

UCLA CARE-4-Families (LABAC CRS), Los Angeles

91803

University of Southern California, Alhambra

92103

UCSD Mother-Child-Adolescent Program, San Diego

97210

The Research + Education Group - Portland, Portland

97239

The Research and Education Group at Portland VA Research Foundation, Portland

411037

Institute of Infectious Diseases, Pune

600113

YRGCARE Medical Centre VHS, Chennai CRS, Chennai

92134-1201

Naval Medical Center San Diego, San Diego

06510

Yale University School of Medicine, New Haven

60611-2605

Lurie Children's Hospital, Chicago

20889-5600

Walter Reed National Military Medical Center, Bethesda

02111

Community Research Initiative of New England, Boston

02118

Boston Medical Center, Boston

08103

Cooper University Hospital, Camden

07103

New Jersey Medical School Adult Clinical Research Center, Newark

27401-1209

Regional Center for Infectious Disease, Greensboro

27157-1042

Wake Forest University Health Sciences, Winston-Salem

38105-3678

St. Jude Children's Research Hospital, Memphis

Unknown

Hospital Nacional Profesor Alejandro Posadas, El Palomar

Hospital Interzonal General de Agudos Dr. Diego Paroissien, Isidro Casanova

CAICI (Instituto Centralizado de Assistencia e Investigacion Clinica Integral), Rosario

FUNCEI, Buenos Aires

Fundacion IDEAA, Buenos Aires

Hospital General de Agudos JM Ramos Mejia, Buenos Aires

Hospital Italiano de Buenos Aires, Buenos Aires

Hospital Rawson, Córdoba

CEIN, Neuquén

Otto-Wagner-Spital SMZ /Baumgartner Hoehe, Vienna

University Vienna General Hospital, Vienna

Institute of Tropical Medicine, Antwerp

Centre Hospitalier Universitaire St. Pierre (C.H.U. St. Pierre), Brussels

Universitaire Ziekenhuizen Gent, Ghent

Universitair Ziekenhuis Gasthuisberg, Leuven

Fundacion Arriaran, Santiago

University Hospital Plzen, CZ, Pilsen

Faculty Hospital Na Bulovce, Prague, Czech Rep., Prague

Arhus Universitetshospital, Skejby, Aarhus

Rigshospitalet, Infektionsmedicinsk ambulatorium 8622, Copenhagen

Hvidovre University Hospital, Department of Infectious Diseases, Hvidovre

Odense University Hospital, Odense

West Tallinn Central Hospital Infectious Diseases, Tallinn

Helsinki University Central Hospital, Div. of Infectious Diseases CRS, Helsinki

CHU de Besan�on - H�pital Jean-Minjoz, Besançon

CHU C�te de Nacre, Caen

H�pital Antoine Becl�re, Clamart

H�pital Henri Mondor, Créteil

H�pital de Bicetre, Le Kremlin-Bicêtre

Groupe Hospitalier Pitie-Salpetri�re, Paris

H�pital Europeen Georges Pompidou, Paris

H�pital H�tel Dieu, Paris

H�pital Saint-Antoine, Paris

H�pital Saint-Louis, Paris

H�pital Foch, Suresnes

Centre Hospitalier - H�pital Gustave Dron, Tourcoing

EPIMED-Gesellschaft fur epidemiologische und klinische Forschung in der MedizinmbH, Berlin

Gemeinschaftspraxis Jessen-Jessen-Stein, Berlin

Medizinische Universitatsklinik - Bonn, Immunologische Ambulanz CRS, Bonn

Klinik I fur Innere Medizin der Universitat zu Koln, Studienburo fur Infektiologie u. HIV, Cologne

Klinikum Dortmund gGmbH, Dortmund

Universitatsklinikum Dusseldorf, Düsseldorf

Universitatsklinikum Erlangen, Erlangen

Klinik fur Dermatologie, Venerologie, Allergologie, Essen

Johann Wolfgang Goethe - University Hospital, Infektionsambulanz CRS, Frankfurt

ICH Study Center, Hamburg

Ifi - Studien und Projekte GmbH, Hamburg

Universitatsklinikum Hamburg-Eppendorf, Hamburg

Medizinische Hochschule Hannover, Hanover

Universitatsklinikum Heidelberg, Heidelberg

Klinikum der Universitat Munchen, Munich

Universitatsklinikum Regensburg, Regensburg

Universitatsklinikum Wurzburg, Medizinische Klinik und Poliklinik II, Schwerpunkt Infektiologie CRS, Würzburg

Attikon University General Hospital, Athens

Evangelismos General Hospital, Athens

Hippokration University General Hospital of Athens, Athens

Korgialenio-Benakio Hellenic Red Cross, Athens

Syngros Hospital, Athens

AHEPA University Hospital, Thessaloniki

Mater Misericordiae University Hospital, Dublin

Rambam Medical Center, Haifa

Tel Aviv Sourasky Medical Center, Tel Aviv

Ospedale San Raffaele S.r.l., Milan

Lazzaro Spallanzani IRCSS, Rome

Centre Hospitalier de Luxembourg, Luxembourg

University Malaya Medical Centre, Kuala Lumpur

Serefo/Cesac Mali, Bamako

INCMNSZ (Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran), Tlalpan

Institute of Human Virology-Nigeria (IHVN), Abuja

Oslo University Hospital, Ulleval, Oslo

Uniwersytecki Szpital Kliniczny, Bialystok

Wojewodzki Szpital Zakazny, Warsaw

EMC Instytut Medyczny SA, Wroclaw

Hospital Curry Cabral, Lisbon

Hospital de Egas Moniz, Lisbon

Hospital de Santa Maria, Lisbon

Hospital Joaquim Urbano, Porto

Desmond Tutu HIV Foundation Clinical Trials Unit, Cape Town

Durban International Clinical Research Site (WWH), Durban

Durban International Clinical Research Site, Durban

CHRU, Johannesburg

1 Military Hospital, Pretoria

Hospital Universitario Principe de Asturias, Alcalá de Henares

Hospital Universitari Germans Trias i Pujol, Badalona

Hospital Clinic de Barcelona, Barcelona

Hospital de la Santa Creu i Sant Pau, Barcelona

Hospital del Mar, Barcelona

Hospital Clinico San Carlos, Madrid

Hospital La Paz, Madrid

Hospital La Princesa, Internal Medicine and Infectious Disease Service CRS, Madrid

Hospital Universitario Doce de Octubre, Madrid

Hospital Universitari Mutua Terrassa, Terrassa

Hospital Universitario y Politecnico La Fe, Valencia

Complejo Hospitalario Xeral Cies, Vigo

Sahlgrenska University Hospital, Gothenburg

Skane University Hospital, Malmo

University Hospital Basel, Basel

Bern University Hospital, Bern

Unite VIH/SIDA Geneva, Geneva

University Hospital Zurich, Zurich

MRC/UVRI Research Unit on AIDS, Entebbe

Joint Clinical Research Center (JCRC), Kampala

29040-091

Center for Infectious Diseases at the UFES, Vitória

40110-010

SEI - Servi�os Especializados em Infectologia, Salvador

20210-030

Hospital Escola Sao Francisco de Assis - UFRJ, Rio de Janeiro

21040-900

Ipec/Fiocruz, Rio de Janeiro

01246-900

Instituto de Infectologia Emilio Ribas - IIER, São Paulo

04121-000

Centro de Referencia e Treinamento DST/Aids, São Paulo

05403-000

Lim 56/Hcfmusp, São Paulo

01

Via Libre, Lima

04

Asociacion Civil IMPACTA Salud y Educacion, Lima

00935

San Juan Hospital, Rio Piedras

Puerto Rico-AIDS Clinical Trials Unit (PR-ACTU), San Juan

00935-6528

University of Puerto Rico Pediatric Research Site, San Juan

RG1 5LE

Royal Berkshire Hospital, Reading

TS4 3BW

The James Cook University Hospital, Middlesbrough

BH7 7DW

Royal Bournemouth Hospital, Bournemouth

BN2 1ES

Brighton and Sussex University Hospitals NHS Trust, Brighton

LE1 5WW

Leicester Royal Infirmary, Leicester

BT12 6BA

Belfast Health and Social Care Trust (RVH), Belfast

S10 2JF

Sheffield Teaching Hospital NHS Foundation Trust, Sheffield

B15 2WB

Queen Elizabeth Hospital Birmingham, Birmingham

B9 5SS

Birmingham Heartlands Hospital, Birmingham

CV1 4FS

Coventry and Warwickshire NHS partnership Trust, Coventry

BS10 5NB

Southmead Hospital, Bristol

GL1 3NN

Gloucestershire Royal Hospital, Gloucester

E1 1BB

Barts Health NHS Trust, London

NW3 2QG

Royal Free London NHS Foundation Trust, London

SE1 7EH

Guy's and St.Thomas' NHS Foundation Trust, London

SE18 4QH

Lewisham and Greenwich NHS Trust, London

SW10 9NH

Chelsea and Westminster Hospital, London

SW17 0QT

St. George's Healthcare NHS Trust, London

W2 1NY

Imperial College Healthcare NHS Trust, London

WC1E 6JB

University College London Medical School, London

M8 5RB

North Manchester General Hospital, Manchester

All Listed Sponsors
collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

collaborator

Copenhagen HIV Programme (CHIP) -- Copenhagen, Denmark

UNKNOWN

collaborator

Medical Research Council

OTHER_GOV

collaborator

Kirby Institute

OTHER_GOV

collaborator

Washington D.C. Veterans Affairs Medical Center

FED

collaborator

ANRS, Emerging Infectious Diseases

OTHER_GOV

collaborator

German Federal Ministry of Education and Research

OTHER_GOV

collaborator

NEAT - European AIDS Treatment Network

OTHER

collaborator

National Health and Medical Research Council, Australia

OTHER

collaborator

National Institutes of Health Clinical Center (CC)

NIH

collaborator

National Cancer Institute (NCI)

NIH

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

National Institute of Mental Health (NIMH)

NIH

collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

collaborator

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NIH

collaborator

Abbott

INDUSTRY

collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Gilead Sciences

INDUSTRY

collaborator

GlaxoSmithKline

INDUSTRY

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Tibotec Pharmaceutical Limited

INDUSTRY

lead

University of Minnesota

OTHER