Augmented Berlin-Frankfurt-Munster (BFM) Therapy for Adolescent/Young Adults With Acute Lymphoblastic Leukemia or Acute Lymphoblastic Lymphoma

PHASE2CompletedINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

September 12, 2006

Primary Completion Date

July 26, 2018

Study Completion Date

July 26, 2018

Conditions
Lymphoblastic LeukemiaLymphoblastic Lymphoma
Interventions
DRUG

Daunorubicin

Starting Dose 25 mg/m\^2 by vein weekly

DRUG

Vincristine

Starting Dose 2 mg by vein weekly

DRUG

PEG-asparaginase

Starting Dose 2000 International units/m2 by vein in week 1

DRUG

Intrathecal Methotrexate

Starting Dose 12 mg on week 2 and week 5 injected into spinal fluid

DRUG

Cyclophosphamide

Starting Dose 1g/m2 by vein in weeks 1 and 5

DRUG

Cytarabine

75 mg/m2 subcutaneous or by vein for four consecutive days on days 1-4 and days 8-11 of both months

DRUG

Mercaptopurine

Starting Dose 60 mg/m2 by mouth on days 1-14 of each month

DRUG

Methotrexate

"Starting Dose at 100 mg/m2 by vein and escalating by 50 mg/m2/dose every 10~+/- 2 days for 5 doses to toxicity (e.g myelosuppression or mucositis grade 3"

DRUG

Doxorubicin

25 mg/m2 by vein in weeks 1, 2 and 3

DRUG

Thioguanine

60 mg/m2 by mouth daily for two weeks

Trial Locations (1)

77030

University of Texas MD Anderson Cancer Center, Houston

All Listed Sponsors
lead

M.D. Anderson Cancer Center

OTHER

NCT00866749 - Augmented Berlin-Frankfurt-Munster (BFM) Therapy for Adolescent/Young Adults With Acute Lymphoblastic Leukemia or Acute Lymphoblastic Lymphoma | Biotech Hunter | Biotech Hunter