120
Participants
Start Date
September 12, 2006
Primary Completion Date
July 26, 2018
Study Completion Date
July 26, 2018
Daunorubicin
Starting Dose 25 mg/m\^2 by vein weekly
Vincristine
Starting Dose 2 mg by vein weekly
PEG-asparaginase
Starting Dose 2000 International units/m2 by vein in week 1
Intrathecal Methotrexate
Starting Dose 12 mg on week 2 and week 5 injected into spinal fluid
Cyclophosphamide
Starting Dose 1g/m2 by vein in weeks 1 and 5
Cytarabine
75 mg/m2 subcutaneous or by vein for four consecutive days on days 1-4 and days 8-11 of both months
Mercaptopurine
Starting Dose 60 mg/m2 by mouth on days 1-14 of each month
Methotrexate
"Starting Dose at 100 mg/m2 by vein and escalating by 50 mg/m2/dose every 10~+/- 2 days for 5 doses to toxicity (e.g myelosuppression or mucositis grade 3"
Doxorubicin
25 mg/m2 by vein in weeks 1, 2 and 3
Thioguanine
60 mg/m2 by mouth daily for two weeks
University of Texas MD Anderson Cancer Center, Houston
M.D. Anderson Cancer Center
OTHER