1,931
Participants
Start Date
January 31, 2008
Primary Completion Date
October 31, 2013
Study Completion Date
February 28, 2014
Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin
"Moxifloxacin 400 mg Rifampicin \< 45 kg 450 mg \> 45 kg 600 mg Isoniazid 300 mg Pyrazinamide \< 40 kg 25 mg/kg rounded to nearest 500 mg\* 40-55 kg 1000 mg \> 55 kg - 75 kg 1500 mg \> 75 kg 2000 mg Ethambutol \< 40 kg 15 mg/kg rounded to nearest 100 mg 40-55 kg 800 mg \> 55 kg - 75 kg 1200 mg \> 75 kg 1600 mg \*For pyrazinamide dosing in patients \< 40 kg, 1000 mg used instead of 500 mg~All treatment is taken daily, for a duration of up to 26 weeks depending on treatment arm."
Clinical HIV Research Unit (CHRU), Johannesburg
Centre for TB Research and Innovation, University of Cape Town Lung Institute, Cape Town
Rajavithi Hospital, Division Of Pulmonary Medicine, Bangkok
Chest Disease Institute (CDI), Ministry of Public,, Nonthaburi
Srinagarind Hospital, Division of Pulmonary Medicine, Khon Kaen University, Khon Kaen
Hospital General de Occidente de la secretaria, Guadalajara
Institute of Respiratory Medicine (IPR) Jalan Pahang, Kuala Lumpur
Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing
Dr. D.K. Chauhan, New Delhi
Centre for advanced lung and sleep disorders, New Delhi
Dr. Mittal's clinic, New Delhi
Diligent Hospital, New Delhi
A-One Hospital, Delhi
Shanghai Pulmonary Hospital, Shanghai
TB Institute, Tianjin
Dr. R. K. Garg's Clinic,, Ghaziabad
Nirmal Kumar Jain, Jaipur
Mahatma Gandhi Medical College& Hospital, Jaipur
Ram-Tej Hospital,, Agra
Siddharth Nursing Home,, Agra
Rajul Nursing Home, Aligarh
Varshneya Chest Clinic & Eye Care Centre, Aligarh
Dr. Neeraj Gupta Clinic, Firozabad
S.P.S Chauhan Clinic, Firozabad
Indra Nursing Home and Maternity Centre, Ghaziabad
Dr. AK Singh Clinic, Kanpur
Dr. S. K. Katiyar, Swaroop Nagar,, Kanpur
Guru Tej Bahadur Hospital, Kanpur
Dr. Komal Gupta, Lucknow
New City Hospital and Trauma Centre,, Lucknow
Surya Chest Foundation,, Lucknow
Surya Kant Clinic, Lucknow
Arya Chest Clinic, UP,India, Meerut
Dr. Mahip Saluja Clinic, U.P., Meerut
Dr. S. P. Sondhi Clinic,, Meerut
Sri Ram Plaza, Meerut
Jigyasa Medical Center, Morādābād
Saanvi MultiSpeciality Clinic,, Morādābād
Ish Medical Centre and Respiratory Lab,, New Delhi
Smt Prakash Devi Memorial Medical Centre,, New Delhi
Centre for Respiratory Disease Research at KEMRI, Nairobi
Tiervlei Trial Center and University of Stellenbosch, Cape Town
Unit for Clinical & Biomedical TB Research, MRC Durban, Durban
NIMR Mbeya Medical Research Programme, Mbeya
Kilimanjaro Christian Medical Centre, Moshi
University Teaching Hospital, Lusaka
Madibeng centre for Research, 40 Pienaar Street,, Madibeng
Collaborators (1)
European and Developing Countries Clinical Trials Partnership (EDCTP)
OTHER_GOV
University College, London
OTHER
Bayer Healthcare Pharmaceuticals, Inc./Bayer Schering Pharma
INDUSTRY
Sanofi
INDUSTRY
Global Alliance for TB Drug Development
OTHER