Analgesic Efficacy And Safety of Tanezumab Added On To Diclofenac SR In Patients With Osteoarthritis Of The Knee Or Hip

PHASE3TerminatedINTERVENTIONAL
Enrollment

607

Participants

Timeline

Start Date

August 11, 2009

Primary Completion Date

November 16, 2010

Study Completion Date

November 24, 2010

Conditions
Osteoarthritis
Interventions
BIOLOGICAL

tanezumab

IV tanezumab 10 mg every 8 weeks (through Week 16)

DRUG

diclofenac

Oral diclofenac SR 75 mg BID for 32 weeks

BIOLOGICAL

tanezumab

IV tanezumab 5 mg every 8 weeks (through Week 16)

DRUG

diclofenac

Oral diclofenac SR 75 mg BID for 32 weeks

BIOLOGICAL

tanezumab

IV tanezumab 2.5 mg every 8 weeks (through Week 16)

DRUG

diclofenac

Oral diclofenac SR 75 mg BID for 32 weeks

DRUG

diclofenac

Oral diclofenac SR 75 mg BID for 32 weeks

OTHER

IV placebo

IV placebo to match tanezumab every 8 weeks (through Week 16)

Trial Locations (77)

3541

Nuhr Zentrum, Senftenberg

10117

Charité-Universitaetsmedizin Berlin, Berlin

13125

Klinische Forschung Berlin-Buch GmbH, Berlin

Viereck-Apotheke, Buch

13353

Apotheke, Berlin

14467

Apotheke des Ernst von Bergmann Klinikums, Potsdam

Synexus ClinParm GmbH, Potsdam

14480

Kirchsteig Apotheke, Potsdam

15705

Hospital Nuestra Señora de la Esperanza, Santiago de Compostela

15706

Hospital Clinico Universitario Santiago, Santiago de Compostela

20253

Falken Apotheke Hoheluft, Hamburg

Klinische Forschung Hamburg GmbH, Hamburg

21018

Vinnytsya regional clinical hospital named after M.I. Pyrogova, Vinnytsia

28007

Hospital G. U. Gregorio Maranon, Madrid

28905

Hospital Universitario Getafe, Getafe-Madrid

30159

Klinische Forschung Hannover - Mitte GmbH, Hanover

Loewen-Apotheke, Hanover

39104

Synexus ClinPharm GmbH, Magdeburg

39112

Apotheke im MSZ, Magdeburg

44093

CHU de Nantes, Nantes

44787

Herz Apotheke, Bochum

Synexus ClinPharm GmbH, Bochum

46001

"Communal Institution Ternopil regional council, Ternopil Regional Clinical Hospital", Ternopil

48013

Hospital de Basurto, Bilbao

49008

Road Clinical Hospital at Dnipropetrovsk station, Department of Rheumatology, Dnipropetrovsk

58000

Chernivtsi Regional Clinical Hospital,Department of Rheumatology, Chernivtsi

61176

City Clinical Hospital #8, Department of reumatology,, Kharkiv

69118

"Communal institution City Hospital #7, Department of Therapy,", Zaporizhzhia

73033

Schiller Apotheke & Stadt Apotheke, Göppingen

Schmerz- und Palliativzentrum Goeppingen, Göppingen

75010

Hopital Lariboisiere, Paris

76018

Ivano-Frankivsk Regional Clinical Hospital, Ivano-Frankivsk

79011

4th City Communal Clinical Hospital, Department of Rheumatology,, Lviv

79013

City communal clinical hospital #5, Dept. of Therapy, Danylo Galytskiy Lviv National Med. University, Lviv

83045

Institute of Urgent and Recovery Surgery named after V.K. Gusaka AMS Ukraine, Donetsk

83114

Central City Clinical Hospital#1, Department of Therapy,, Donetsk

100337

"Municipal Hospital No. 1 Schuller", Ploieşti

111539

"State Healthcare Institution of Moscow city City Clinical Hospital #15 n.a. O. M. Filatov", Moscow

163000

Center polyclinic of Federal State Institution, Arkhangelsk

190068

"St. Petersburg State Healthcare Institution City Hospital #25 City Rheumatology Center", Saint Petersburg

191015

State Educational Institution of Additional Professional Education, Saint Petersburg

194017

"Institution of Russian Academy of Sciences St. Petersburg Clinical Hospital of RAS", Saint Petersburg

196211

"St. Petersburg State Healthcare Institution City Outpatient Clinical #51", Saint Petersburg

199106

"St. Petersburg State Healthcare Institution City Pokrovskaya Hospital", Saint Petersburg

390026

Chair of Hospital Therapy of Ryazan State Medical University, Ryazan

800578

"County Emergency Clinic Hospital Sf. Apostol Andrei", Galati

900591

Clinical Emergency County Hospital Constanta, Constanța

A-8036

LKH-Medizinische Universitatsklinik Graz, Graz

A-1090

ClinPharm International GmbH, Vienna

Medizinische Universitaet Wien/AKH, Vienna

A-1100

Rheuma Zentrum Favoriten, Vienna

01067

Synexus ClinParm GmbH, Dresden

01127

Apotheke im Arztehaus Mickten, Dresden

04103

Synexus ClinPharm GmbH, Leipzig

04315

Arkana Apotheke OHG, Leipzig

41-403

"Centrum Medyczne MEDENS S.C. Niepubliczny Zaklad", Chełm Śląski

31-510

Malopolskie Centrum Medyczne s.c., Krakow

02-256

Centrum Medyczne OSTEOMED Sp. z o. o., Warsaw

50-088

Synexus SCM Sp. z o.o., Wroclaw

95-100

"Niepubliczny Zaklad Opieki Zdrowotnej POLIMEDICA", Zgierz

010225

"Clinical Emergency Military Hospital Dr. Carol Davila", Bucharest

010584

Duo Medical srl, Bucharest

011025

"Medical Center SANA", Bucharest

011172

"Clinical Hospital Sf. Maria", Bucharest

020985

"Center of Rheumatology Dr Ion Stoia", Bucharest

03610

Centro Salud Petrer 1, Petrel

03600

Hospital Comarcal de Elda, Elda Alicante

400 14

Me3plus AB, Gothenburg

412 63

Me3plus AB, Gothenburg

211 52

Center for Lakemedelsstudier, Malmo

602 32

Medicinskt Centrum, Norrköping

04114

"State Institution Institute of Gerontology AMS of Ukraine", Kiev

01023

Oleksandrivska Clinical Hospital in Kyiv-Department of Rheumatology # 1, Kyiv

04053

Kyiv Central Basin Clinical Hospital, Department of cardiology,, Kyiv

S75 2EP

Barnsley Hospital NHS Trust, Barnsley

DY1 2HQ

Department of Rheumatology, Dudley, West Midlands

WN6 9EP

Wrightington Hospital, Wigan

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY