Therapy Protocol Acute Lymphoblastic Leukemia Stem Cell Transplantation International

"According to results from published experiences in children following suggestions are given:~1. Number of Cells:~ * Number of nucleated cells infused exceed 2,5x10\*7/kg recipient BW or~ * Number of nucleated cells collected exceed 3x10\*7/kg BW~ * Number of CD34+ cells infused exceed 2x10\*5/kg Recipient BW~2. GVHD-prophylaxis:~ • MSD: CSA 3 mg/kg as described in the protocol + Prednisolone 1 mg/kg (day O to day 15, then tapering until day 28)~ • UD: as above + additional immunosuppression according to local protocols; ATG might increase risk of infectious complication and might be replaced by other drugs according to local protocols.~3. HLA-matching for unrelated CB: a matched UB is defined by 6/6 HLA matches (A, B antigenic medium resolution and DRB1 allelic) and allocate to the transplantation group MD. Less than 6/6 HLA matches allocate the patient to the MMD group.~4. If many choices available ABO- major incompatibility should be avoided."