Development of 1-Day Rest/Stress Cardiac PET Perfusion Imaging Protocol of BMS747158

PHASE2CompletedINTERVENTIONAL
Enrollment

176

Participants

Timeline

Start Date

January 31, 2009

Primary Completion Date

June 30, 2010

Study Completion Date

June 30, 2010

Conditions
Ischemia
Interventions
DRUG

BMS747158

"dosages at rest and at stress were not to exceed a total of 14 mCi.~Cohort 1: Patients received either 2 or 3 IV bolus injections of BMS747158: 1 at rest and 1 or 2 during stress, over a 1-day or 2-day period.~Cohort 2: Patients to recieve IV bolus injections of BMS747158:~For the Pharmacologic (Adenosine) Stress:~* Doses at rest were to range between 2.9 and 3.4 mCi.~* Doses under stress were to be a factor of 2.0 to 2.4 greater than the rest dose, resulting in a range of stress doses between 5.8 and 8.2 mCi.~For the Exercise Stress:~* Doses at rest were to range between 1.7 and 2.0 mCi.~* Doses under stress were to be a factor of 3.0 to 3.6 greater than the rest dose, resulting in a range between 5.1 and 7.2 mCi."

Trial Locations (24)

10032

Columbia University Medical Center, New York

11576

St. Francis Hospital, Roslyn

27934

East Tennessee Clinical Research Institute, Knoxville

30322

Emory University Hospital, Atlanta

37604

Mountain States Health Alliance, Johnson City

43214

Midwest Cardiology Research Foundation, Columbus

44106

University Hospital Case Medical Center, Cleveland

48109

University of Michigan, Ann Arbor

63110

Saint Louis University, St Louis

Washington University School of Medicine, St Louis

64101

Cardiovascular Consultants, Kansas City

90095

Cedars-Sinai Medical Center, Los Angeles

UCLA Medical Plaza, Los Angeles

92037

Scripps Memorial Hospital, La Jolla

92161

VA Healthcare System San Diego, San Diego

94538

Silicon Valley Medical Imaging, Fremont

95816

Radiological Associates of Sacramento, Sacramento

05102-5037

Hartford Hospital, Hartford

06520

Yale University, New Haven

01432

Primary Care Cardiology Research, Inc, Ayer

02114

Massachusetts General Hospital, Boston

02115

Brigham & Women's Hospital, Boston

07107

University of Medicine and Dentistry of New Jersey, Newark

07666

Holy Name Hospital, Teaneck

Sponsors
All Listed Sponsors
lead

Lantheus Medical Imaging

INDUSTRY