A 2-Year Phase 3 Study Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate

PHASE3CompletedINTERVENTIONAL
Enrollment

800

Participants

Timeline

Start Date

March 31, 2009

Primary Completion Date

April 30, 2011

Study Completion Date

February 29, 2012

Conditions
Arthritis, Rheumatoid
Interventions
DRUG

CP-690,550

Oral tablets administered at 5 mg BID daily for 6 months (nonresponders advance to second intervention at 3 months) during the double-blind, placebo-controlled period.

DRUG

CP-690,550

Oral tablets administered at 5 mg BID daily through the end of the study during the double-blind, active-extension period.

DRUG

CP-690,550

Oral tablets administered at 10 mg BID daily for 6 months (nonresponders advance to second intervention at 3 months) during the double-blind, placebo-controlled period.

DRUG

CP-690,550

Oral tablets administered at 10 mg BID daily through the end of the study during the double-blind, active-extension period.

DRUG

Placebo

Oral placebo tablets administered BID daily for 6 months (nonresponders advance to second intervention at 3 months) during the double-blind, placebo-controlled period.

DRUG

CP-690,550

Oral tablets administered at 5 mg BID daily through the end of the study during the double-blind, active-extension period.

DRUG

Placebo

Oral placebo tablets administered BID daily for 6 months (nonresponders advance to second intervention at 3 months) during the double-blind, placebo-controlled period.

DRUG

CP-690,550

Oral tablets administered at 10 mg BID daily through the end of the study during the double-blind, active-extension period.

Trial Locations (115)

0

Pfizer Investigational Site, Medellín

100

Pfizer Investigational Site, Taipei

112

Pfizer Investigational Site, Taipei

333

Pfizer Investigational Site, Kweishan, Taoyuan County

407

Pfizer Investigational Site, Taichung

704

Pfizer Investigational Site, Tainan City

807

Pfizer Investigational Site, Kaohsiung City

1606

Pfizer Investigational Site, Sofia

1709

Pfizer Investigational Site, Sofia

3145

Pfizer Investigational Site, Malvern East

4000

Pfizer Investigational Site, Plovdiv

4002

Pfizer Investigational Site, Plovdiv

4558

Pfizer Investigational Site, Maroochydore

5011

Pfizer Investigational Site, Woodville

11000

Pfizer Investigational Site, Prague

12206

Pfizer Investigational Site, Albany

13210

Pfizer Investigational Site, Syracuse

13905

Pfizer Investigational Site, Binghamton

14000

Pfizer Investigational Site, Mexico City

15213

Pfizer Investigational Site, Pittsburgh

19610

Pfizer Investigational Site, Wyomissing

20902

Pfizer Investigational Site, Wheaton

21018

Pfizer Investigational Site, Vinnitsa

26301

Pfizer Investigational Site, Clarksburg

29601

Pfizer Investigational Site, Greenville

32216

Pfizer Investigational Site, Jacksonville

32607

Pfizer Investigational Site, Gainesville

33542

Pfizer Investigational Site, Zephyrhills

33614

Pfizer Investigational Site, Tampa

34239

Pfizer Investigational Site, Sarasota

35801

Pfizer Investigational Site, Huntsville

40536

Pfizer Investigational Site, Lexington

45417

Pfizer Investigational Site, Dayton

48025

Pfizer Investigational Site, Bingham Farms

49048

Pfizer Investigational Site, Kalamazoo

52002

Pfizer Investigational Site, Dubuque

53132

Pfizer Investigational Site, Franklin

55435

Pfizer Investigational Site, Edina

58070

Pfizer Investigational Site, Morelia

60053

Pfizer Investigational Site, Morton Grove

61178

Pfizer Investigational Site, Kharkiv

61300

Pfizer Investigational Site, Brno

64086

Pfizer Investigational Site, Lee's Summit

65203

Pfizer Investigational Site, Columbia

65212

Pfizer Investigational Site, Columbia

68114

Pfizer Investigational Site, Omaha

68134

Pfizer Investigational Site, Omaha

75231

Pfizer Investigational Site, Dallas

77074

Pfizer Investigational Site, Houston

78217

Pfizer Investigational Site, San Antonio

79011

Pfizer Investigational Site, Lviv

80910

Pfizer Investigational Site, Colorado Springs

85704

Pfizer Investigational Site, Tucson

92108

Pfizer Investigational Site, San Diego

93454

Pfizer Investigational Site, Santa Maria

95017

Pfizer Investigational Site, Simferopol

500003

Pfizer Investigational Site, Secunderabad

21224-6821

Pfizer Investigational Site, Baltimore

01605

Pfizer Investigational Site, Worcester

37909-1900

Pfizer Investigational Site, Knoxville

74110-120

Pfizer Investigational Site, Goiânia

80060-240

Pfizer Investigational Site, Curitiba

22271-100

Pfizer Investigational Site, Rio de Janeiro

90035-903

Pfizer Investigational Site, Porto Alegre

90610-000

Pfizer Investigational Site, Porto Alegre

04266-010

Pfizer Investigational Site, São Paulo

05437-010

Pfizer Investigational Site, São Paulo

T5M 0H4

Pfizer Investigational Site, Edmonton

V8V 3P9

Pfizer Investigational Site, Victoria

A1A 5E8

Pfizer Investigational Site, St. John's

L8N 2B6

Pfizer Investigational Site, Hamilton

L3Y 3R7

Pfizer Investigational Site, Newmarket

M5T 3L9

Pfizer Investigational Site, Toronto

H2L 1S6

Pfizer Investigational Site, Montreal

G1V 3M7

Pfizer Investigational Site, Québec

0000

Pfizer Investigational Site, Barranquilla

Unknown

Pfizer Investigational Site, Bogota

Pfizer Investigational Site, Bucaramanga

Pfizer Investigational Site, Kitakyushu

Pfizer Investigational Site, Higashihiroshima

Pfizer Investigational Site, Hitachi-shi

Pfizer Investigational Site, Sagamihara

Pfizer Investigational Site, Koushi

Pfizer Investigational Site, Sendai

Pfizer Investigational Site, Ohmura

Pfizer Investigational Site, Sasebo

Pfizer Investigational Site, Ureshino-shi

Pfizer Investigational Site, Kawagoe-shi

Pfizer Investigational Site, Hamamatsu

Pfizer Investigational Site, Bunkyo-ku

Pfizer Investigational Site, Shinjuku-ku

Pfizer Investigational Site, Shinjuku-ku, Tokyo

615 00

Pfizer Investigational Site, Brno - Zidenice

253 01

Pfizer Investigational Site, Hostivice

530 02

Pfizer Investigational Site, Pardubice

128 50

Pfizer Investigational Site, Prague

148 00

Pfizer Investigational Site, Praha 11 - Chodov

760 01

Pfizer Investigational Site, Zlín

54 636

Pfizer Investigational Site, Thessaloniki

500 004

Pfizer Investigational Site, Hyderabad

560 034

Pfizer Investigational Site, Bangalore

560 079

Pfizer Investigational Site, Bangalore

575 001

Pfizer Investigational Site, Mangalore

411 001

Pfizer Investigational Site, Pune

02-256

Pfizer Investigational Site, Warsaw

50-088

Pfizer Investigational Site, Wroclaw

302-799

Pfizer Investigational Site, Daejeon

400-711

Pfizer Investigational Site, Incheon

110-744

Pfizer Investigational Site, Seoul

120-752

Pfizer Investigational Site, Seoul

133-792

Pfizer Investigational Site, Seoul

135-710

Pfizer Investigational Site, Seoul

137-701

Pfizer Investigational Site, Seoul

138-736

Pfizer Investigational Site, Seoul

04114

Pfizer Investigational Site, Kyiv

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY