p53 Synthetic Long Peptides Vaccine With Cyclophosphamide for Ovarian Cancer

The P53-SLP vaccine is a vaccine consisting of a total of 10 long (30 amino acids on average length) peptides, covering the p53 protein sequence from amino acid 70 to 251, combined with Montanide ISA51 an adjuvant with a sustained dendritic cell activating ability. Patients will be immunised subcutaneously with the peptide vaccine four times with a three week interval (300μg/peptide).

Two days prior to each peptide vaccination, patients will receive 300mg/m2 cyclophosphamide i.v.