Acarbose Cardiovascular Evaluation Trial

PHASE4CompletedINTERVENTIONAL
Enrollment

6,526

Participants

Timeline

Start Date

February 17, 2009

Primary Completion Date

April 11, 2017

Study Completion Date

April 18, 2017

Conditions
Coronary Heart DiseaseAcute Coronary SyndromeImpaired Glucose ToleranceType 2 Diabetes Mellitus (T2DM)
Interventions
DRUG

Acarbose

The participants were given one tablet (50mg) of acarbose per day, taken with a meal during their first week (7 days). During the second week, the dose was increased to two tablets/day (50mg twice a day i.e. 100mg/day) and then three tablets/day (50mg three times a day i.e. 150mg/day) thereafter. The maximum tolerated dose is being taken for the duration of the trial (maximum dose is 150mg/day).

DRUG

Matching Placebo

The participants were given one tablet of matching placebo per day, taken with a meal during their first week (7 days). During the second week, the dose was increased to two tablets/day and then three tablets/day thereafter. The maximum tolerated dose is being taken for the duration of the trial (maximum dose is 3 tablets/day).

Trial Locations (177)

100022

Beijing Chuiyangliu Hospital, Beijing

100028

China Meitan General Hospital, Beijing

100029

Beijing Anzhen Hospital of The Capital University of Medical Sciences, Beijing

China-Japan Friendship Hospital, Beijing

100034

Peking University First Hospital, Beijing

100035

Beijing Ji Shui Tan Hospital, Beijing

100038

Beijing Shijitan Hospital, Beijing

Fu Xing Hospital, Beijing

100043

Beijing Shijingshan Hospital, Beijing

100044

Peking University People's Hospital, Beijing

100049

Aerospace Central Hospital, Beijing

100050

Affiliated to The Capital University of Medical Sciences Beijing Friendship Hospital, Beijing

100053

Wangjing Hospital of CACMS, Beijing

Xuanwu Hospital Capital Medical University, Beijing

100054

Beijing Healthy Palace Hospital, Beijing

100074

Aerospace 731 Hospital, Beijing

100088

General Hospital of Second Artillery PLA, Beijing

100730

Peking Union Medical College Hospital, Beijing

100853

PLA General Hospital, Beijing

101200

Anzhen Hospital of The Capital University of Medical Sciences 2nd., Beijing

Beijing Pinggu Hospital, Beijing

102500

Beijing Yanhua Hospital, Beijing

110004

Shengjing Hospital of China Medical University, Shenyang

110016

The People's Hospital of Liaoning Province, Shenyang

110021

Shengjing Hospital of China Medical University, Shenyang

110032

The Fourth Hospital of China Medical University, Shenyang

114001

The Central Hospital of Anshan, Anshan

116001

Affiliated Zhongshan Hospital of Dalian University, Dalian

116011

The First Hospital of Dalian Medical University, Dalian

116033

Dalian Central Hospital, Dalian

130033

China-Japan Union Hospital of Jilin University, Changchun

130041

The Second Hospital of Jilin University, Changchun

150001

The Fourth Affiliated Hospital of Harbin Medical University, Harbin

163001

Da Qing Oilfield General Hospital, Daqing

200011

Shanghai Ninth People's Hospital, Shanghai

200025

Ruijin Hospital Affiliated to the Shanghai Jiaotong University Medical School, Shanghai

200031

Shanghai Central Hospital of Xuhui District, Shanghai

200032

Shanghai Zhongshan Hospital, Shanghai

200040

Shanghai Huadong Hospital, Shanghai

200060

Shanghai Putuo District People's Hospital, Shanghai

200062

Putuo District Center Hospital, Shanghai

200065

Tongji Hospital of Tongji University, Shanghai

200072

Shanghai Tenth People's Hospital, Shanghai

200081

Number 411 Hospital of PLA, Shanghai

200090

Shanghai Central Hospital of Yangpu District, Shanghai

200092

Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai

200120

Shanghai East Hospital, Shanghai

200127

Renji Hospital Affilicated to Jiaotong University School of Medicine, Shanghai

200135

Shanghai Pudong New Area Gongli Hospital, Shanghai

200433

Changhai Hospital, Shanghai

200435

Shanghai Zhabei District Shibei Hospital, Shanghai

200540

Shanghai Jinshan Hospital, Shanghai

201200

Shanghai Pudong New District People's Hospital, Shanghai

210002

81st Hospital of Chinese PLA, Nanjing

210006

Nanjing First Hospital, Nanjing

210008

Nanjing Drum Tower Hospital, Nanjing

210009

Nanjing Zhongda Hospital, Nanjing

210017

BENQ Hospital, Nanjing

210024

Jiangsu Province Official Hospital, Nanjing

210029

Jiangsu Province Hospital, Nanjing

Jiangsu Provincial Hospital of TCM, Nanjing

211100

Nanjing Jiangning Hospital, Nanjing

212002

Zhenjiang First People's Hospital, Zhenjiang

214002

Wuxi No.2 People's Hospital, Wuxi

214023

Wuxi People's Hospital, Wuxi

214041

Wuxi No.3 People's Hospital, Wuxi

215000

Suzhou Municipal Hospital, Suzhou

221000

Hospital Affiliated Xuzhou Medical University, Xuzhou

221006

The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou

230032

The First Affiliated Hospital of Anhui Medical University, Hefei

250013

The Central Hospital of Jinan, Jinan

The First People's Hospital of Jinan, Jinan

250031

The General Hospital of Jinan Military Region, Jinan

266003

Hospital Affiliated of Medical School, Qingdao University, Qingdao

266011

The Qingdao Municiple Hospital, Qingdao

266034

Qingdao Fuwai Hospital, Shibei

271000

Taian City Central Hospital, Taian

276003

Linyi People's Hospital, Linyi

300050

Tianjin Union Hospital, Tianjin

300051

Tianjin Chest Hospital, Tianjin

300121

Tianjin Union Medicine Centre, Tianjin

300162

Army Police's Medical College Affiliated Hospital, Tianjin

300170

Tianjin Third Central Hospital, Tianjin

300192

Tianjin First Center Hospital, Tianjin

300211

The Second Hospital of Tianjin Medical University, Tianjin

300280

Dagang Oil-Field General Hospital, Tianjin

300450

The Fifth Central Hospital of Tianjin, Tianjin

310013

Zhe Jiang Hospital, Hangzhou

310016

Sir Run Run Shaw Hospital Affiliated With School of Medicine, Zhe Jiang University, Hangzhou

330006

Jiangxi Provincial People's Hospital, Nanchang

The Second Affiliated Hospital of Nanchang University, Nanchang

330008

The Third Affiliated Hospital of Nanchang University, Nanchang

332000

Jiujiang University Hospital, Jiujiang

350001

Fujian Provincial Hospital, Fuzhou

Union Hospital Affiliated to Fujian Medical University, Fuzhou

350004

The People's Hospital of Fujian Province, Fuzhou

361003

The First Hospital of Xiamen, Xiamen

361004

Zhongshan Hospital Xiamen University, Xiamen

400010

Chongqing Medical University Second Afflicated Hospital, Chongqing

400013

Chongqing Zhongshan Hospital, Chongqing

400014

Chongqing Third People's Hospital, Chongqing

400016

The First Affiliated Hospital of Chongqing Medical University, Chongqing

400042

Da Ping Hospital, Chongqing

402160

The Second People's Hospital of Chongqing, Chongqing

410005

Hunan Provincial People's Hospital, Changsha

410006

The Fourth Hospital of Changsha, Changsha

410008

Xiangya Hospital Central-South University, Changsha

410015

The Third Hospital of Changsha, Changsha

430022

Union Hospital of Tongji Medical College of Huazhong, Wuhan

Wuhan Asia Heart Hospital, Wuhan

430030

Tongji Hospital of Tongji Medical College of Huazhong, Wuhan

430033

Pu'ai Hospital of Wuhan City, Wuhan

430060

Renmin Hospital of Wuhan University, Wuhan

430071

Zhongnan Hospital of Wuhan University, Wuhan

450000

The First Affiliated Hospital of Henan College of TCM, Zhengzhou

450003

The People's Hospital of Zhengzhou, Zhengzhou

450014

The Second Affiliated Hospital of Zhengzhou University, Zhengzhou

471003

The First Affiliated Hospital of Henan Science & Technology University, Luoyang

471009

Luo Yang Central Hospital, Affiliated to Zhengzhou University, Luoyang

510080

Guangdong General Hospital, Guangzhou

The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou

The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou

510120

Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou

510150

The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou

510507

Wu Jing Zhong Dui Hospital of Guangdong Province, Guangzhou

510630

The First Affiliated Hospital of Jinan University, Guangzhou

518036

Peking University Shenzhen Hospital, Shenzhen

519000

The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai

528403

Zhong Shan City People's Hospital, Zhongshan

530001

Minzu Hospital of Guangxi Zhuang Autonomous Region, Nanning

530021

303 Hospital of People's Liberation Army, Nanning

The First Affiliated Hospital of Guangxi Medical University, Nanning

545005

Liuzhou Worker's Hospital, Liuzhou

545006

Liuzhou People's Hospital, Liuzhou

550004

The Affiliated Hospital of Guiyang Medical College, Guiyang

610016

Chengdu First People's Hospital, Chengdu

610017

Chengdu Second People's Hospital, Chengdu

610041

Sichuan Provincial People's Hospital, Chengdu

The West China Hospital, Chengdu

621000

Sichuan Mianyang 404 Hospital, Sichuan

650032

The First Affiliated Hospital of Kunming Medical College, Kunming

The First People's Hospital of Yunnan Province, Kunming

650101

The Second Affiliated Hospital of Kunming Medical College, Kunming

653100

People's Hospital of Yuxi City, Yuxi

710003

Xi'an Central Hospital, Xi'an

710054

PLA No.323 Hospital, Xi’an

710061

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an

710077

Affiliated Hospital of Xi'an Medical college, Xi'an

712000

Xianyang Central Hospital, Shengyang

716000

Affiliated Hospital of Yan'an University, Yan’an

Yan'an People's Hospital, Yan’an

719000

The First Hospital of Yulin, Yulin

750001

The First Hospital of Yinchuan, Yinchuan

750004

Affiliated Hospital of Ningxia Medical University, Yinchuan

750021

The People's Hospital of Ningxia Hui Autonomous Region, Yinchuan

830000

Xin Jiang Traditional Chinese Medicine Hospital, Ürümqi

830002

General Hospital of Xinjiang Production and Construction Corps, Ürümqi

830013

The 474th Hospital of PLA, Ürümqi

830054

The First Teaching Hospital of Xinjiang Medical University, Ürümqi

832008

First Affiliated Hospital of the Medical College, Shihezi

062650

Cangzhou Central Hospital, Cangzhou

050000

The Second Hospital of Hebei Medical University, Shijiazhuang

050031

The First Hospital of Hebei Medical University, Shijiazhuang

050082

Bethune International Peace Hospital, Shijiazhuang

063000

Tangshan Workers Hospital, Tangshan

The Affiliated Hospital of North China Coal Medical University, Tangshan

064100

Yu Tian County Hospital, Tangshan

075000

The Third Affiliated Hospital of Hebei North University, Zhangjiakou

014010

The First Affiliated Hospital of Baotou Medical College, Baotou

014040

Baotou Central Hospital, Baotou

024000

Chifeng Municipal Hospital, Chifeng

010017

Inner Mongolia Hospital, Hohhot

030003

General Hospital of Tisco, Taiyuan

030006

The Third Engineering Bureau Hospital of Ministry of Railway, Taiyuan

030009

Taiyuan City Central Hospital, Taiyuan

030024

Shanxi Cardiovascular Hospital, Taiyuan

Unknown

Prince of Wales Hospital, Hong Kong

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bayer

INDUSTRY

lead

University of Oxford

OTHER