PEAK: Panitumumab Plus mFOLFOX6 vs. Bevacizumab Plus mFOLFOX6 for First Line Treatment of Metastatic Colorectal Cancer (mCRC) Patients With Wild-Type Kirsten Rat Sarcoma-2 Virus (KRAS) Tumors

PHASE2CompletedINTERVENTIONAL
Enrollment

285

Participants

Timeline

Start Date

April 24, 2009

Primary Completion Date

May 30, 2012

Study Completion Date

July 7, 2016

Conditions
Colon CancerColorectal CancerRectal CancerMetastatic Colorectal Cancer
Interventions
DRUG

Panitumumab

Panitumumab is a fully human immunoglobulin G (IgG)2 monoclonal antibody antagonist directed against human Epidermal Growth Factor receptor (EGFr).

DRUG

Bevacizumab

Bevacizumab is a humanized monoclonal IgG1 antibody that is directed against Vascular Endothelial Growth Factor (VEGF).

DRUG

mFOLFOX6

mFOLFOX6 regimen is a combination therapy of oxaliplatin (85 mg/m\^2) administered as a 2-hour infusion on Day 1; leucovorin (400 mg/m\^2) administered as a 2-hour infusion on Day 1; followed by a loading dose of 5-fluorouracil (5-FU; 400 mg/m\^2) IV bolus administered over approximately 2 to 4 minutes on Day 1, then 5- FU (2400 mg/m\^2) via ambulatory pump administered for a period of 46 to 48 hours.

Trial Locations (95)

2650

Research Site, Edegem

6000

Research Site, Charleroi

6800

Research Site, Libramont

9100

Research Site, Sint-Niklaas

10301

Research Site, Staten Island

11733

Research Site, East Setauket

12051

Research Site, Alba (CN)

13125

Research Site, Berlin

14215

Research Site, Buffalo

15006

Research Site, A Coruña

16132

Research Site, Genova

17033

Research Site, Hershey

19106

Research Site, Philadelphia

20817

Research Site, Bethesda

21100

Research Site, Varese

21204

Research Site, Baltimore

23320

Research Site, Chesapeake

23601

Research Site, Newport News

23606

Research Site, Newport News

27607

Research Site, Raleigh

28078

Research Site, Huntersville

28702

Research Site, San Sebastián de Los Reyes

29010

Research Site, Málaga

29464

Research Site, Mt. Pleasant

29605

Research Site, Greenville

30005

Research Site, Alpharetta

30901

Research Site, Augusta

31405

Research Site, Savannah

32114

Research Site, Daytona Beach

33021

Research Site, Hollywood

33065

Research Site, Coral Springs

33100

Research Site, Udine

33435

Research Site, Boynton Beach

33467

Research Site, Lake Worth

33611

Research Site, Bielefeld

35205

Research Site, Birmingham

35805

Research Site, Huntsville

38120

Research Site, Memphis

39008

Research Site, Santander

39104

Research Site, Magdeburg

40422

Research Site, Danville

41701

Research Site, Hazard

42003

Research Site, Paducah

43228

Research Site, Columbus

44304

Research Site, Akron

46100

Research Site, Mantova

46237

Research Site, Indianapolis

48144

Research Site, Lambertville

48912

Research Site, Lansing

49048

Research Site, Kalamazoo

60031

Research Site, Gurnee

61032

Research Site, Fano

61615

Research Site, Peoria

66210

Research Site, Overland Park

67214

Research Site, Wichita

75231

Research Site, Dallas

75702

Research Site, Tyler

76508

Research Site, Temple

78463

Research Site, Corpus Christi

78665

Research Site, Round Rock

78759

Research Site, Austin

80218

Research Site, Denver

81737

Research Site, München

81925

Research Site, München

83854

Research Site, Post Falls

87131

Research Site, Albuquerque

90211

Research Site, Beverly Hills

91505

Research Site, Burbank

91750

Research Site, La Verne

92501

Research Site, Riverside

92708

Research Site, Fountain Valley

92868

Research Site, Orange

93049

Research Site, Regensburg

94032

Research Site, Passau

94704

Research Site, Berkeley

95661

Research Site, Roseville

97070

Research Site, Würzburg

98684

Research Site, Vancouver

99218

Research Site, Spokane

06902

Research Site, Stamford

06708

Research Site, Waterbury

02111

Research Site, Boston

07046

Research Site, Mountain Lakes

07871

Research Site, Sparta

05009

Research Site, White River Junction

T2N 4N2

Research Site, Calgary

T6G 1Z2

Research Site, Edmonton

V5Z 4E6

Research Site, Vancouver

V8R 6V5

Research Site, Victoria

L1G 2B9

Research Site, Oshawa

J4V 2H1

Research Site, Greenfield Park

H2X 3J4

Research Site, Montreal

G1R 2J6

Research Site, Québec

08208

Research Site, Sabadell

03203

Research Site, Elche

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY