Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock

PHASE4TerminatedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

January 31, 2009

Primary Completion Date

May 31, 2011

Study Completion Date

June 30, 2011

Conditions

Septic ShockAcute Renal Failure

Interventions

DRUG

Piperacillin/Tazobactam

eGFR 20-40 mls/min: Piperacillin/Tazobactam 3.375g IV q6h x 24 hours eGFR \< 20 mls/min: Piperacillin/Tazobactam 2.25g IV q6h x 24 hours

DRUG

Piperacillin/Tazobactam

Piperacillin/Tazobactam 4.5g IV q 6h x 24 hours

Trial Locations (1)

Royal Columbian Hospital, New Westminster