QUILT-2.018: Safety & Efficacy of FOLFIRI With AMG 479 or AMG 655 vs FOLFIRI Alone in KRAS-mutant Metastatic Colorectal Carcinoma

PHASE2CompletedINTERVENTIONAL
Enrollment

155

Participants

Timeline

Start Date

March 31, 2009

Primary Completion Date

January 31, 2011

Study Completion Date

June 30, 2012

Conditions
Metastatic Colorectal Cancer
Interventions
OTHER

FOLFIRI

"Day 1 of each Cycle~Combination Therapy of:~irinotecan 180 mg/m2 90-minute infusion leucovorin 400 mg/m2 2 hour infusion 5-FU 400 mg/m2 IV bolus 5-FU 2,400 mg/m2 46-48 hour infusion"

BIOLOGICAL

AMG 655

AMG 655 is an investigational, fully human, monoclonal antibody that selectively binds to Death Receptor-5 (DR-5)

OTHER

Placebo

Inactive dummy agent (to maintain blind)

BIOLOGICAL

AMG 479

AMG 479 is an investigational, fully human, monoclonal antibody that binds with Insulin-like growth factor receptor type 1

Trial Locations (67)

1097

Research Site, Budapest

6720

Research Site, Szeged

7624

Research Site, Pécs

9023

Research Site, Győr

10032

Research Site, New York

10043

Research Site, Orbassano

12534

Research Site, Hudson

16132

Research Site, Genova

19106

Research Site, Philadelphia

19107

Research Site, Philadelphia

20142

Research Site, Milan

24014

Research Site, Roanoke

27262

Research Site, High Point

28040

Research Site, Madrid

28041

Research Site, Madrid

30341

Research Site, Atlanta

31008

Research Site, Pamplona

33076

Research Site, Bordeaux

33136

Research Site, Miami

34471

Research Site, Ocala

34952

Research Site, Port Saint Lucie

42003

Research Site, Paducah

43235

Research Site, Columbus

46037

Research Site, Fishers

59020

Research Site, Lille

60435

Research Site, Joliet

60637

Research Site, Chicago

67214

Research Site, Wichita

69373

Research Site, Lyon

75231

Research Site, Dallas

75702

Research Site, Tyler

76508

Research Site, Temple

78731

Research Site, Austin

79106

Research Site, Amarillo

80218

Research Site, Denver

80220

Research Site, Denver

90095

Research Site, Los Angeles

90211

Research Site, Beverly Hills

92100

Research Site, Boulogne-Billancourt

93454

Research Site, Santa Maria

115478

Research Site, Moscow

119228

Research Site, Singapore

163045

Research Site, Arkhangelsk

169610

Research Site, Singapore

191104

Research Site, Saint Petersburg

197089

Research Site, Saint Petersburg

249036

Research Site, Obninsk

305035

Research Site, Kursk

308433

Research Site, Singapore

443031

Research Site, Samara

450054

Research Site, Ufa

01655

Research Site, Worcester

03756

Research Site, Lebanon

Unknown

Research Site, New Territories

500 082

Research Site, Hyderabad

400 012

Research Site, Mumbai

440 012

Research Site, Nagpur

422 005

Research Site, Nashik

411 004

Research Site, Pune

700 016

Research Site, Kolkata

560 029

Research Site, Bangalore

80-952

Research Site, Gdansk

44-101

Research Site, Gliwice

45-060

Research Site, Opole

08035

Research Site, Barcelona

08036

Research Site, Barcelona

08907

Research Site, L'Hospitalet de Llobregat

Sponsors

Lead Sponsor

All Listed Sponsors
lead

NantCell, Inc.

INDUSTRY

NCT00813605 - QUILT-2.018: Safety & Efficacy of FOLFIRI With AMG 479 or AMG 655 vs FOLFIRI Alone in KRAS-mutant Metastatic Colorectal Carcinoma | Biotech Hunter | Biotech Hunter