Therapeutic Induction of Endogenous Antibiotics

PHASE2CompletedINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

January 31, 2005

Primary Completion Date

December 31, 2008

Study Completion Date

January 31, 2009

Conditions
Shigellosis
Interventions
BIOLOGICAL

Sodium Butyrate

Patients will be instructed to lie on a bed (cholera cot) in left lateral position. A soft rectal catheter will be introduced by a nurse/physician, through which 80 ml of butyrate solution will be instilled slowly with a 50 ml plastic syringe. Patients will be asked to retain the enema for at least ½ hour by remaining supine for 30 minutes after the administration. However, if a patient cannot retain the enema for 30 minutes, he will be given a second round of enema immediately after defecation.

BIOLOGICAL

Saline

Patients will be instructed to lie on a bed (cholera cot) in left lateral position. A soft rectal catheter will be introduced by a nurse/physician, through which 80 ml of saline solution will be instilled slowly with a 50 ml plastic syringe. Patients will be asked to retain the enema for at least ½ hour by remaining supine for 30 minutes after the administration. However, if a patient cannot retain the enema for 30 minutes, he will be given a second round of enema immediately after defecation.

Trial Locations (2)

1212

Dhaka Hospital & Matlab Hospital, Dhaka

ICDDR,B, Dhaka

All Listed Sponsors
collaborator

Swedish International Development Cooperation Agency (SIDA)

OTHER_GOV

collaborator

Karolinska Institutet

OTHER

lead

International Centre for Diarrhoeal Disease Research, Bangladesh

OTHER

NCT00800930 - Therapeutic Induction of Endogenous Antibiotics | Biotech Hunter | Biotech Hunter