Low Dose Supplementation to Improve Anticoagulation Control With Oral Vitamin K as an Adjuvant to Warfarin Therapy

PHASE3CompletedINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

November 30, 2008

Primary Completion Date

April 30, 2010

Study Completion Date

April 30, 2010

Conditions
Coagulation
Interventions
DIETARY_SUPPLEMENT

Vitamin K1 (Phytonadione)

Vitamin K1 tablets (100 micrograms per tablet) will be taken by patients randomized to the Vitamin K arm. Dosage is two tablets per day (200 micrograms per day) to be taken with warfarin for the 6 month study period.

DIETARY_SUPPLEMENT

Placebo

Lactose-based placebo tablets (identical in appearance to the Vitamin K1 tablets) will be taken by patients randomized to the placebo arm. Dosage is two tablets per day to be taken with warfarin for the 6 month study period.

Trial Locations (1)

K1Y4E9

Ottawa Hospital Thrombosis Clinic, Ottawa

All Listed Sponsors
lead

Ottawa Hospital Research Institute

OTHER