Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

97

Participants

Timeline

Start Date

September 1, 2009

Primary Completion Date

June 1, 2016

Study Completion Date

January 6, 2026

Conditions
Acute Lymphoblastic LeukemiaAdult B Acute Lymphoblastic LeukemiaAdult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1Adult L1 Acute Lymphoblastic LeukemiaAdult L2 Acute Lymphoblastic LeukemiaAdult T Acute Lymphoblastic LeukemiaRecurrent Adult Acute Lymphoblastic Leukemia
Interventions
PROCEDURE

Allogeneic Hematopoietic Stem Cell Transplantation

Undergo allogeneic stem cell transplant

DRUG

Cyclophosphamide

Given IV

DRUG

Cytarabine

Given IT

DRUG

Dasatinib

Given PO

DRUG

Dexamethasone

Given IV or PO

DRUG

Doxorubicin Hydrochloride

Given IV

DRUG

Etoposide

Given IV

BIOLOGICAL

Filgrastim

Given SC

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Leucovorin Calcium

Given IV

DRUG

Methotrexate

Given IV or IT

DRUG

Methylprednisolone

Given IV

PROCEDURE

Peripheral Blood Stem Cell Transplantation

Undergo allogeneic stem cell transplant

DRUG

Prednisone

Given PO

DRUG

Sirolimus

Given PO

DRUG

Tacrolimus

Given IV

RADIATION

Total-Body Irradiation

Undergo TBI

DRUG

Vincristine Sulfate

Given IV

Trial Locations (157)

10461

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

Montefiore Medical Center - Moses Campus, The Bronx

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

16803

Mount Nittany Medical Center, State College

17044

Lewistown Hospital, Lewistown

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

26506

West Virginia University Healthcare, Morgantown

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

29425

Medical University of South Carolina, Charleston

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

32610

University of Florida Health Science Center - Gainesville, Gainesville

32803

AdventHealth Orlando, Orlando

37232

Vanderbilt University/Ingram Cancer Center, Nashville

40536

University of Kentucky/Markey Cancer Center, Lexington

44106

Case Western Reserve University, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

45177

Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center, Wilmington

45236

The Jewish Hospital, Cincinnati

45331

Wayne Hospital, Greenville

45373

Upper Valley Medical Center, Troy

45385

Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

45415

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45459

Dayton NCI Community Oncology Research Program, Dayton

45801

Saint Rita's Medical Center, Lima

45840

Blanchard Valley Hospital, Findlay

46107

Franciscan Saint Francis Health-Beech Grove, Beech Grove

46845

Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne

47374

Reid Health, Richmond

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

49017

Bronson Battle Creek, Battle Creek

49307

Spectrum Health Big Rapids Hospital, Big Rapids

49444

Trinity Health Muskegon Hospital, Muskegon

49503

Cancer Research Consortium of West Michigan NCORP, Grand Rapids

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49684

Munson Medical Center, Traverse City

51101

Siouxland Regional Cancer Center, Sioux City

51102

Mercy Medical Center-Sioux City, Sioux City

51104

Saint Luke's Regional Medical Center, Sioux City

53226

Medical College of Wisconsin, Milwaukee

55905

Mayo Clinic in Rochester, Rochester

57105

Avera Cancer Institute, Sioux Falls

59101

Billings Clinic Cancer Center, Billings

Saint Vincent Healthcare, Billings

59102

Montana Cancer Consortium NCORP, Billings

Saint Vincent Frontier Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59601

Saint Peter's Community Hospital, Helena

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59715

Bozeman Health Deaconess Hospital, Bozeman

59802

Montana Cancer Specialists, Missoula

Saint Patrick Hospital - Community Hospital, Missoula

59901

Glacier Oncology PLLC, Kalispell

Logan Health Medical Center, Kalispell

60035

Hematology Oncology Associates of Illinois-Highland Park, Highland Park

60048

AMG Libertyville - Oncology, Libertyville

60076

Hematology Oncology Associates of Illinois - Skokie, Skokie

60153

Loyola University Medical Center, Maywood

60402

MacNeal Hospital and Cancer Center, Berwyn

60563

DuPage Medical Group-Ogden, Naperville

60611

Hematology and Oncology Associates, Chicago

Northwestern University, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

60714

Illinois Cancer Specialists-Niles, Niles

60901

Presence Saint Mary's Hospital, Kankakee

62781

Springfield Memorial Hospital, Springfield

63104

SSM Health Saint Louis University Hospital, St Louis

63110

Washington University School of Medicine, St Louis

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64108

University Health Truman Medical Center, Kansas City

64131

The University of Kansas Cancer Center-South, Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

66044

Lawrence Memorial Hospital, Lawrence

66112

University of Kansas Cancer Center-West, Kansas City

66160

University of Kansas Cancer Center, Kansas City

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66606

University of Kansas Health System Saint Francis Campus, Topeka

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

66762

Mercy Hospital Pittsburg, Pittsburg

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

Wesley Medical Center, Wichita

Wichita NCI Community Oncology Research Program, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

Salina Regional Health Center, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

67502

Hutchinson Regional Medical Center, Hutchinson

67601

HaysMed, Hays

67801

Cancer Center of Kansas - Dodge City, Dodge City

67901

Southwest Medical Center, Liberal

67905

Cancer Center of Kansas-Liberal, Liberal

70112

Tulane University School of Medicine, New Orleans

70809

Hematology/Oncology Clinic PLLC, Baton Rouge

71103

LSU Health Sciences Center at Shreveport, Shreveport

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75246

Baylor University Medical Center, Dallas

77030

M D Anderson Cancer Center, Houston

82609

Rocky Mountain Oncology, Casper

82801

Welch Cancer Center, Sheridan

84003

American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

84143

LDS Hospital, Salt Lake City

84321

Logan Regional Hospital, Logan

84403

McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center, Provo

84720

Sandra L Maxwell Cancer Center, Cedar City

84770

Saint George Regional Medical Center, St. George

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

91010

City of Hope Comprehensive Cancer Center, Duarte

94304

Stanford Cancer Institute Palo Alto, Palo Alto

95817

University of California Davis Comprehensive Cancer Center, Sacramento

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Harborview Medical Center, Seattle

Minor and James Medical PLLC, Seattle

98109

Fred Hutchinson Cancer Center, Seattle

98112

Kaiser Permanente Washington, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98166

Highline Medical Center-Main Campus, Burien

98195

University of Washington Medical Center - Montlake, Seattle

98221

Cancer Care Center at Island Hospital, Anacortes

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98274

Skagit Valley Hospital, Mount Vernon

98284

PeaceHealth United General Medical Center, Sedro-Woolley

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98383

Saint Michael Cancer Center, Silverdale

98801

Wenatchee Valley Hospital and Clinics, Wenatchee

99202

Cancer Care Northwest - Spokane South, Spokane

99218

Evergreen Hematology and Oncology PS, Spokane

99336

Kadlec Clinic Hematology and Oncology, Kennewick

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

57117-5045

Avera McKennan Hospital and University Health Center, Sioux Falls

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH