IMA910 Plus GM-CSF With Low-dose Cyclophosphamide Pre-treatment in Advanced Colorectal Carcinoma Patients Following a Successful 12 Week First-line Treatment With Oxaliplatin-based Chemotherapy (IMA910-101)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

92

Participants

Timeline

Start Date

June 30, 2008

Primary Completion Date

January 31, 2011

Study Completion Date

May 31, 2013

Conditions
Colorectal Carcinoma
Interventions
DRUG

Endoxana, Leukine, IMA910

a single i.v. infusion of 300 mg/m2 Endoxana (Cyclophosphamide) and then 3 days later (visit 1) patients will start vaccination therapy with intradermal (i.d.) injections of 75µg GM-CSF followed by i.d. injections of 5.78 mg IMA90

DRUG

Endoxana, Leukine, IMA910, Aldara

a single i.v. infusion of 300 mg/m2 Endoxana (Cyclophosphamide) and then 3 days later (visit 1) patients will start vaccination therapy with intradermal (i.d.) injections of 75µg GM-CSF followed by i.d. injections of 5.78 mg IMA90 followed by Aldara (Imiquimod)

Trial Locations (41)

1002

Pauls Stradins University Hospital, Riga

1062

State Health Center Oncology, Budapest

1076

Péterfy Hospital, Budapest

1079

Latvia oncological Center, Riga

1085

Semmelweis University, Oncoradiology, Budapest

1122

"National Institute of Oncology, Department of Internal Medicine, Department of Chemotherapy B", Budapest

1145

Uszoki Hospital, Budapest

1233

District Dispensary for Oncology Diseases with Inpatient Unit, Sofia District, Chemotherapeutic Ward, Sofia

1527

"MHAT Tsaritsa Yoanna, Clinic of Oncotherapy", Sofia

1756

Specialized Hospital for Active Treatment in Oncology Ltd., Clinic of Chemotherapy, Sofia

2820

Medische Oncologie, Imeldaziekenhuis, Bonheiden

3526

Borsod County Hospital, Miskolc

4004

Inter District Dispencary for Oncology Disease with Inpatient Unit Plovdiv, First Internal Ward, Plovdiv

6720

University of Szeged, Department of Oncotherapy, Szeged

8000

St. Gyorgy County Hospital, Székesfehérvár

9000

Oncologisch Centrum, UZ Gent, Ghent

"Interdistrict Dispensary of Oncology Diseases with Inpatient Unit Dr. Marko Markov - Varna", Varna

11000

Institute for Oncology and Radiology of Serbia, National Cancer Research Center, Clinical Research and Exp. Pharmacology, Belgrade

Vojnomedicinska Akademija, Clinic for Gastroenterology, Military Medical Academy, Belgrade

21204

Oncology Institute of Vojvodina, Sremska

45659

Prosper-Hospital, Med. Klinik I, Recklinghausen

60488

Krankenhaus Nordwest der Stiftung Hospital zum heiligen Geist, II. med. Klinik, Frankfurt a.M.

72076

University of Tübingen, Department of med. Oncology, Hematology, Immunology, Rhematology and Pulmology, Tübingen

78050

Kliniken Villingen, Schwarzwald-Baar-Klinik, Dept. Of Hematology & Oncology, Villingen-Schwenningen

79111

Cancer Hospital Sanafontis, Freiburg im Breisgau

87100

Wojewodzki Szpital Zespolony im. Ludwika Rydygiera, Oddzial Chemiotherapii, Torun

89081

Universitätsklinikum Ulm, Dep. Of Internal Medicine I, Studiensekretariat, CCCU, CTOA, Ulm

400015

"Oncology Institute Prof. Dr. Ion Chiricuta", Cluj-Napoca

540072

Spitalul Clinic Judetean, Târgu Mureş

4170167

Clinical County Hospital Oradea, Oncology Clinic, Oradea

01307

"University Hospital Dresden Carl Gustav Carus", Dresden

44-100

Centrum Onkologii Instytut im. Marii Skłodowskiej-Curie Klinika Onkologii Klinicznej, Gliwice

93-509

Klinika Chemioterapii Nowotworów, Regionalny Ośrodek Onkologiczny, Wojewódzki Szpital Specjalistyczny im. M.Kopernika Uniwersytetu Medycznego Łódz, Lodz

02-097

Katedra i Klinika Hematologii, Onkologii i Cherob Wewnetrznych AM SP Centralny Szpital Kliniczny w Warszawie, Warsaw

BN2 5BD

The Royal Sussex County Hospital, CIR-Unit, Brighton

CB2 0QQ

University of Cambridge, Department of Oncology, Cambridge

CF14 2TL

Velindre Cancer Centre, Cardiff

GU2 7XX

St Luke's Cancer Centre, The Royal Surrey County Hospital, Guildford / Surrey

LS9 7TF

St. James's Hospital, Leeds

LE1 5WW

Leicester Royal Infirmary, Leicester

OX3 7LJ

Churchill Hospital, Dept.of Clinical Pharmacology, Oxford

Sponsors
All Listed Sponsors
lead

Immatics Biotechnologies GmbH

INDUSTRY