Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III

PHASE3CompletedINTERVENTIONAL
Enrollment

500

Participants

Timeline

Start Date

July 31, 2009

Primary Completion Date

July 31, 2015

Study Completion Date

January 31, 2016

Conditions
Intraventricular Hemorrhage
Interventions
DRUG

Alteplase

1.0 mg of alteplase will be administered via the intraventricular catheter every 8 hours for up to 12 doses

OTHER

Normal saline

1 ml of normal saline will be administered via the intraventricular catheter every 8 hours for up to 12 doses

Trial Locations (81)

1134

Honved Korhaz, Budapest

4032

University of Debrecen, Debrecen

6725

University of Szeged, Szeged

7623

University of Pecs, Pécs

10029

Mount Sinai Hospital, New York

10032

Columbia University, New York

11030

Northshore University Hospital Long Island, Manhasset

13210

SUNY Upstate Medical Center, Syracuse

14203

University of Buffalo, Buffalo

15212

Allegheny General Hospital, Pittsburgh

15213

University of Pittsburgh Medical Center, Pittsburgh

17033

Penn State Hershey Medical Center, Hershey

19001

Abington Memorial Hospital, Abington

19107

Thomas Jefferson University Hospital, Philadelphia

19140

Temple University Hospital, Philadelphia

19141

Albert Einstein Medical Center, Philadelphia

20007

Georgetown University, Washington D.C.

21201

University of Maryland, Baltimore

21230

Johns Hopkins University, Baltimore

23298

Virginia Commonwealth University, Richmond

27157

Wake Forest University, Winston-Salem

29425

Medical University of South Carolina, Charleston

31096

Rambam Medical Center, Haifa

32224

Mayo Clinic, Jacksonville, Jacksonville

33606

University of South Florida, Tampa

34232

Intercoastal Medical Center, Sarasota

35294

University of Alabama at Birmingham, Birmingham

37232

Vanderbilt, Nashville

43210

Ohio State University Medical Center, Columbus

44106

Case-Western Reserve University Hospital, Cleveland

45219

University of Cincinnati, Cincinnati

48202

Henry Ford Health System, Detroit

50314

Ruan Neurology Clinical and Research Center, Des Moines

52242

University of Iowa, Iowa City

52621

Chaim Sheba Medical Center, Ramat Gan

53226

Medical College of Wisconsin, Milwaukee

60612

Rush University, Chicago

University of Illinois at Chicago, Chicago

60637

University of Chicago, Chicago

63104

St. Louis University, St Louis

64111

St. Luke's Brain and Stroke Institute, Kansas City

64239

Sourasky Medical Center, Tel Aviv

65804

Springfield Neurological and Spine Institute, Springfield

66160

Kansas University Medical Center, Kansas City

69120

University of Heidelberg, Heidelberg

72076

University of Tubingen, Tübingen

75390

University of Texas, Southwestern, Dallas, Dallas

77030

University of Texas, Houston, Houston

78229

University of Texas, San Antonio, San Antonio

84132

University of Utah, Salt Lake City

85054

Mayo Clinic, Arizona, Phoenix

90048

Cedars-Sinai Medical Center, Los Angeles

90089

University of Southern California - Keck School of Medicine, Los Angeles

90095

University of California Los Angeles, Los Angeles

91054

University of Erlangen, Erlangen

91120

Hadassah Hebrew University Hospital, Jerusalem

94034

Stanford University, Palo Alto

97225

Providence Stroke Center, Portland

89202165

Hospital Sao Jose, Joinville, Joinville

06106

Hartford Hospital, Hartford

06520-8018

Yale University, New Haven

08103

Cooper University Hospital, Camden

08818

New Jersey Neuroscience Institute at JFK, Edison

04102

Maine Medical Center, Portland

90035-903

Hospital de Clinicas de Porto Alegre, Porto Alegre

Unknown

Hospital de Pronto Socorro de Porto Alegre, Porto Alegre

University Hospital, Inselpital, Bern, Bern

14015-130

Hospital de Clinicas de Ribeirao Preto, Ribeirão Preto

04039032

Hospital Sao Paulo Universidade Federal de Sao Paulo / UNIFESP, São Paulo

T6G 2B7

University of Alberta, Edmonton

H3A 2B4

Montreal Neurological Institute at McGill University, Montreal

D-06120

University of Halle, Halle

04103

University of Leipzig, Leipzig

D-55131

University of Mainz, Mainz

08015

Bellvitge Hospital, Barcelona

08025

Hospital de la Santa Creu i Sant Pau, Barcelona

08035

Vall d'Hebron University Hospital, Barcelona

CH-8091

University of Zurich, Zurich

M6 8HD

Salford Royal NHS Foundation Trust, Salford

NE4 6BE

Newcastle General Hospital, Newcastle upon Tyne

SO16 6YD

University of Southampton Hospital, Southampton

All Listed Sponsors
collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

collaborator

Genentech, Inc.

INDUSTRY

collaborator

Emissary International LLC

INDUSTRY

lead

Johns Hopkins University

OTHER