720
Participants
Start Date
October 16, 2008
Primary Completion Date
September 30, 2029
Study Completion Date
September 30, 2029
Docetaxel
Docetaxel will be administered as per local prescribing information.
Paclitaxel
Paclitaxel will be administered as per local prescribing information.
Pertuzumab
Pertuzumab will be administered intravenously at a dose of 420 milligrams (mg) no more frequently than every 3 weeks (Q3W) (or as directed in the parent study protocol if less than Q3W).
Trastuzumab
Trastuzumab will be administered as per local prescribing information.
Trastuzumab Emtansine
Trastuzumab emtansine will be administered as intravenous (IV) infusion. Participants on weekly dosing schedule of trastuzumab emtansine in parent study, may switch to Q3W schedule as per the clinical judgment of the investigator. The starting dose of Q3W schedule must not exceed 3.6 milligrams per kilograms (mg/kg).
Atezolizumab
Atezolizumab will be administered at a dose of 1200 mg by IV infusion every three weeks (Q3W)
Instituto, Lima
National Taiwan Uni Hospital, Taipei
Chi-Mei Medical Center, Tainan City
Private Health Organization Acibadem Sistina Hospital, Skopje
Institute of Oncology Ljubljana, Ljubljana
Auckland city hospital, Auckland
Szent Margit Hospital, Budapest
Veterans Memorial Medical Ctr, Quezon City
Cardinal Santos Medical Center, San Juan City
SHATO - Sofia, Sofia
ZAS Sint Augustinus Wilrijk, Pharmacy, Wilrijk
Peter MacCallum Cancer Center, Melbourne
Peninsula and South Eastern Haematology and Oncology Group, Frankston
Complex Oncology Center - Plovdiv First Internal Chemotherapy Department, Plovdiv
Debreceni Egyetem, Klinikai Kozpont, Onkologiai Klinika, Debrecen
Odense Universitetshospital, Onkologisk Afdeling R, Odense
Cebu Cancer Institute, Cebu City
Vejle Sygehus, Vejle
Universitätsspital Zürich, Zurich
UZ Gent, Ghent
Markusovszky Hospital, Szombathely
Hospital San Pedro De Alcantara, Cáceres
Laura and ISAAC Perlmutter Cancer Center at NYU Langone., New York
Fondazione Del Piemonte Per L'oncologia Ircc Di Candiolo, Candiolo
Bumrungrad International Hosp, Bangkok
Rajavithi Hospital, Bangkok
National Cancer Center, Gyeonggi-do
Clinical Research Alliance, Lake Success
NS-Long Island Jewish Hlth Sys, Lake Success
Hospital de Jerez de la Frontera, Jerez de la Frontera
Frauenarzt-Zentrum Zehlendorf an der Teltower Eiche, Berlin
HELIOS Klinikum Berlin-Buch, Berlin
Institut Paoli Calmettes, Marseille
Centre Francois Baclesse, Caen
Instituto Nacional de Cancer, D.F.
Instituto Nacional de Enfermedades Neoplasicas, Lima
Christina Care Institutional Review Board, Newark
Hospital de Donostia, Donostia / San Sebastian
Irccs Istituto Nazionale Dei Tumori (Int), Milan
Istituto Europeo Di Oncologia, Milan
Centre Georges Francois Leclerc, Dijon
Anne Arundel Medical Center, Annapolis
Gachon University Gil Medical Center, Incheon
Hospital Universitari Arnau de Vilanova de Lleida, Lleida
Hospital General Universitario Gregorio Marañon, Madrid
Hospital Ramon y Cajal, Madrid
Carolina Oncology Specialists, PA - Hickory, Hickory
Northwest Georgia Oncology Centers PC - Marietta, Marietta
Memorial Cancer Institute at Memorial West, Pembroke Pines
RCCS - Centro di Riferimento, Aviano (PN)
Azienda Ospedaliero-Universitaria Dipartimento Interaziendale Di Oncologia, Udine
Florida Cancer Specialists - Tampa (Dr. MLK Blvd), Tampa
Florida Cancer Specialists (St. Petersburg ? St. Anthony?s Professional Building), St. Petersburg
Florida Cancer Specialists, Fort Myers
Institut régional du Cancer Montpellier, Montpellier
Sarah Cannon Research Institute / Tennessee Oncology, Nashville
Sarah Cannon Research Institute / Tennessee Oncology, Chattanooga
Centro de Investigacion, Acapulco de Juárez
Ospedale Regionale Di Parma, Parma
The Mark H. Zangmeister Ctr, Columbus
Ico Rene Gauducheau, Saint-Herblain
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola, Meldola
Karmanos Cancer Institute, Detroit
Hospital Universitario Miguel Servet, Zaragoza
Oncology Assoc of Cedar Rapids, Cedar Rapids
Hematology-Oncology, Bettendorf
Minnesota Oncology Hematology, Pa, Minneapolis
University of Minnesota., Minneapolis
Mayo Clinic - Rochester, Rochester
Loyola University Med Center, Maywood
Illinois Cancer Care, Peoria
St. John's Mercy Medical Ctr, St Louis
Studienzentrum Aschaffenburg, Aschaffenburg
Mercy Clinic Cancer & Hematology, Springfield
Hopital Tenon, Paris
Texas Oncology - Dallas Presbyterian Hospital, Dallas
Institut Curie, Paris
USO - Tyler Cancer Ctr, Tyler
Texas Oncology, Bedford
Cancer Therapy & Research Center, San Antonio
Univ of Colorado Canc Ctr, Aurora
University of Colorado, Aurora
Istituto Nazionale Tumori Irccs Fondazione g. PASCALE, Napoli
Rocky Mountain Cancer Center - Denver, Denver
Rotkreuzklinikum München, München
Klinikum der Universität München, München
Kootenai Cancer Center, Post Falls
Ospedale San Carlo, Potenza
Campus Universitario S.Venuta, Catanzaro
Comp Cancer Centers of Nevada, Las Vegas
Can Care Assoc Med Group Inc, Redondo Beach
UCLA Oncology Office, Santa Monica
City of Hope National Medical Center, Duarte
Shaare Zedek Medical Center, Jerusalem
Institut Curie - Hopital Rene Huguenin, Saint-Cloud
Central Coast Medical Oncology, San Luis Obispo
Univ of Calif, San Francisco, San Francisco
Kaiser Permanente - Walnut Creek, Walnut Creek
Humanitas Istituto Clinico Catanese S.p.A, Misterbianco (CT)
Northwest Cancer Specialists - Portland (N Broadway), Portland
Univ of WA Medical Center, Seattle
Northwest Medical Specialties, Tacoma
The Affiliated Hospital of Military Medical Sciences(The 307th Hospital of Chinese PLA), Beijing
Beijing Cancer Hospital, Beijing
Seoul National University Hospital, Seoul
Blokhin Cancer Research Center, Moskva
the First Hospital of Jilin University, Changchun
City Clinical Oncology Hospital, Moscow
Harbin Medical University Cancer Hospital, Harbin
FSBI?National Medical Research Center of Oncology named after N.N.Petrov? MHRF, Saint Petersburg
Fudan University Shanghai Cancer Center, Shanghai
Jiangsu Cancer Hospital, Nanjing
Zhejiang Provincial People's Hospital, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
SBI of Healthcare of Stavropol region Stavropol Regional Clinical Oncology Dispensary, Stavropol
Bashkirian Republican Clinical Oncology Dispensary, Ufa
SBIH Republican Clinical Oncological Dispensary of the MoH of Republic Bashkortostan, Ufa
Sun Yet-sen University Cancer Center, Guangzhou
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou
Tel Aviv Sourasky Medical Ctr, Tel Aviv
Fundacion Arturo Lopez Perez, Santiago
Stanford Cancer Institute, Stanford
Johns Hopkins Univ Med Center, Baltimore
Dana Farber Cancer Institute, Boston
St. Barnabas Health Care Sys, Livingston
USO, Plano
Uni of Washington Medical Center, Seattle
Clinica de Oncologia de Porto Alegre - CliniOnco, Porto Alegre
Hospital Nossa Senhora da Conceicao, Porto Alegre
Clinica de Neoplasias Litoral, Itajaí
Faculdade de Medicina do ABC - FMABC, Santo André
Hospital Perola Byington, São Paulo
Instituto Nacional de Cancer - INCa, Rio de Janeiro
BC Cancer ? Kelowna (Sindi Ahluwalia Hawkins Centre), Kelowna
Ottawa Regional Cancer Centre, Ottawa
Saskatoon Cancer Centre, Saskatoon
CHU de Québec ? Hôpital du Saint-Sacrement / ONCOLOGY, Québec
Fakultni nemocnice Olomouc, Olomouc
Fakultni Poliklinika Vseobecne Fakultni Niemocnice, Prague
Grupo Angeles, Guatemala City
Queen Mary Hospital, Hong Kong
City Oncology Dispensary, Saint Petersburg
Ospedale Civile, Sassari
Hiroshima University Hospital, Hiroshima
Hyogo Cancer Center, Hyōgo
Consultorio de Medicina Especializada, Distrito Federal
Oslo Universitetssykehus HF, Oslo
The Panama Clinic, Panama City
Uniwersyteckie Centrum Kliniczne, Gdansk
?wi?tokrzyskie Centrum Onkologii, Kielce
Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii, Otwock
Wielkopolskie Centrum Onkologii, Poznan
Wojewódzki Szpital Specjalistyczny Nr 3, Rybnik
Narodowy Instytut Onkologii im. M.Sklodowskiej-Curie, Warsaw
Hospital da Luz, Lisbon
Kyungpook National University Medical Center, Daegu
Severance Hospital, Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Hospital General Universitario de Elche, Elche
Hospital del Mar, Barcelona
Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Barcelona
Hospital Duran i Reynals, Barcelona
Ninewells Hospital, Dundee
Western General Hospital, Edinburgh
Diana Princess of Wales Hosp., Grimsby
Royal Lancaster Infirmary, Morecambe Bay Hospitals Nhs Trust, Lancaster
Royal Free Hospital, London
Christie Hospital NHS Trust, Manchester
Mount Vernon Hospital, Middlesex
Nottingham City Hospital, Nottingham
Poole General Hospital, Poole
Queen's Hospital, Romford
Abertawe and Bro Morgannwg NHS Trust, Swansea
Royal Cornwall Hospital, Truro
Lead Sponsor
Hoffmann-La Roche
INDUSTRY
Genentech, Inc.
INDUSTRY