21,105
Participants
Start Date
November 30, 2008
Primary Completion Date
April 30, 2013
Study Completion Date
May 31, 2013
warfarin tablets
Warfarin tablets plus Edoxaban placebo tablets each taken once daily for 24 months
Edoxaban tablets (high dose regimen-60mg)
Edoxaban tablets plus warfarin placebo tablets each taken once daily for 24 months
Edoxaban tablets (low dose regimen-30mg)
Edoxaban tablets plus warfarin placebo tablets each taken once daily for 24 months
placebo warfarin
placebo warfarin
placebo edoxaban
placebo edoxaban
Altoona
Fleetwood
Richmond
Norfolk
Greensboro
Charlotte
Morehead City
Morganton
Spartanburg
Greer
Conyers
Snellville
Woodstock
Daytona Beach
Miami
Delray Beach
Leesburg
Springfield
Fremont
West Monroe
Colorado Springs
Belleville
West Valley City
Tempe
Sierra Vista
Birmingham
Mobile
Gilbert
Glendale
Lake Havasu City
Tucson
Harrisburg
Hot Springs
Little Rock
Alhambra
Anaheim
Burbank
Chula Vista
Encinitas
Fountain Valley
Glendale
Healdsburg
Lakewood
Long Beach
Los Alamitos
Los Angeles
Los Banos
Mather
Merced
Newport Beach
Oceanside
Pacific Palisades
Palm Springs
Pismo Beach
Redondo Beach
Sacramento
San Diego
Santa Rosa
Torrance
Ventura
Aurora
Denver
Englewood
Greeley
Bridgeport
Guilford
Hamden
Manchester
New Haven
North Haven
Shelton
Stamford
Trumbull
Newark
Washington D.C.
Aventura
Chipley
Clearwater
Daytona Beach
DeBary
Deerfield Beach
Delray Beach
Hialeah
Hollywood
Jacksonville
Jacksonville Beach
Jupiter
Melbourne
Miami
Naples
Orange Park
Orlando
Ormond Beach
Panama City
Pembroke Pines
Pensacola
Plantation
Port Charlotte
Rockledge
Saint Augustine
Sarasota
St. Petersburg
Stuart
Tamarac
Tampa
The Villages
Vero Beach
West Palm Beach
Athens
Atlanta
Covington
Cumming
Savannah
Tucker
Watkinsville
Waycross
Honolulu
Boise
Hayden Lake
Bannockburn
Chicago
Elgin
Joliet
Libertyville
Maywood
Melrose Park
Oak Lawn
Springfield
Winfield
Bloomington
Munster
Ames
Council Bluffs
Iowa City
Shell Rock
Wichita
Bowling Green
Campbellsville
Elizabethtown
Richmond
Marrero
West Monroe
Auburn
Biddeford
Baltimore
Bel Air
Bethesda
Lexington Park
Rockville
Salisbury
Towson
Westminster
Ayer
Boston
Concord
East Bridgewater
Haverhill
Methuen
Worcester
Bay City
Benzonia
Chelsea
Commerce
Detroit
Grand Rapids
Interlochen
Kalamazoo
Lapeer
Midland
Rochester Hills
Saginaw
Troy
Warren
Golden Valley
Minneapolis
Saint Paul
Biloxi
Chesterfield
Joplin
Kansas City
Saint Charles
St Louis
Kalispell
Grand Island
Lincoln
Omaha
Henderson
Belvidere
Brick
Bridgewater
Browns Mills
Cherry Hill
Elizabeth
Haddon Heights
Hamilton
Mine Hill
Ocean City
Passaic
Ridgewood
Somerset
Toms River
Albuquerque
Albany
Brooklyn
Buffalo
Cortlandt Manor
Hawthorne
Jamaica
Mineola
New York
North Massapequa
Saratoga Springs
Troy
Cary
Chapel Hill
Mooresville
Morganton
Oxford
Pinehurst
Statesville
Winston-Salem
Fargo
Oakes
Akron
Canal Fulton
Canton
Cincinnati
Cleveland
Columbus
Cuyahoga Falls
Dayton
Fairfield
Marion
Middletown
Pitsburg
Thornville
Toledo
Willoughby Hills
Bartlesville
Oklahoma City
Bend
Corvallis
Beaver
Chester
Clymer
Danville
Doylestown
Ephrata
Feasterville
Greenville
Johnstown
Lancaster
Lewistown
Newport
Norristown
Philadelphia
Pittsburgh
Pottstown
Scranton
Sellersville
Somerset
State College
Uniontown
Wilkes-Barre
Wynnewood
Yardley
Providence
Anderson
Charleston
Columbia
Florence
Greenville
Mt. Pleasant
Summerville
Taylors
Walterboro
Rapid City
Columbia
Jackson
Johnson City
Nashville
Oak Ridge
Arlington
Austin
Carrollton
Corsicana
Dallas
Fort Worth
Georgetown
Grapevine
Houston
Lubbock
McAllen
Odessa
Plano
San Antonio
Tomball
Wichita Falls
Provo
Danville
Hopewell
Newport News
Springfield
Suffolk
Virginia Beach
Winchester
Bellevue
Kirkland
Renton
Seattle
Spokane
Tacoma
Clarksburg
Madison
Manitowoc
Menomonee Falls
Bahía Blanca
Buenos Aires
Corrientes
Córdoba
Formosa
Godoy Cruz
Mar del Plata
Mendoza
Paraguay
Provincia de Chaco
Provincia de Rio Negro
Provincia de Salta
San Luis
San Miguel de Tucumán
San Salvador de Jujuy
Santa Fe
Sante Fe
Broken Hill
East Gosford
Carina Heights
Milton
Adelaide
Frankston
Ashford
Camperdown
Elizabeth Vale
Joondalup
Melbourne
Parkville
Perth
Antwerp
Arlon
Bruges
Brussels
Genk
Hasselt
Leuven
Liège
Mechelen
Merksem
Moerkerke
Montegnée
Mousron
Torhout
Veurne
Wetteren
Belo Horizonte
Blumenau
Brasília
Campina Grande do Sul
Campinas
Caxias do Sul
Curitiba
Goiânia
Lajeados
Maceió
Marília
Passo Fundo
Porto Alegre
Recife
Ribeirão Preto
Rio de Janeiro
Salvador
Santo André
São José
São Paulo
Uberlândia
Burgas
Dimitrovgrad
Haskovo
Pleven
Plovdiv
Rousse
Sofia
Varna
Calgary
Campbell River
Chilliwack
Coquitlam
Kamloops
Kelowna
New Westminster
Penticton
Quesnel
Victoria
Saint John
Bridgewater
Halifax
Liverpool
Ajax
Beamsville
Brampton
Corunna
Greater Sudbury
Hamilton
Kitchener
Listowel
London
Oshawa
Ottawa
Richmond Hill
Sarnia
Scarborough Village
Toronto
Greenfield Park
Longueuil
Montreal
Québec
Saint Georges de Beauce
Saint-Charles-Borromée
Saint-Jérôme
Saint-Lambert
Terrebonne
Trois-Rivières
Westmount
Saskatoon
Mount Pearl
St. John's
Iquique
La Serena
Osorno
Port Montt
Rancagua
Santiago
Talcahuano
Temuco
Victoria
Viña del Mar
Baotou
Beijing
Changchun
Changsha
Chendu
Chongqing
Guangxi
Guangzhou
Hainan Province
Hangzhou
Harbin
Jinzhou
Lanzhou
Liaoning Province
Nanchang
Shaanxi Province
Shanghai
Shenyang
Shijiazhuang
Tianjin
Wenzhou
Wuhan
Antioquia
Armenia
Barranquilla
Bogotá
Bucaramanga
Cartagena
Envigado
Manizales
Medellín
Dubrovnik
Karlovac
Koprivnica
Krapinski Toplice
Osijek
Rijeka
Slavonski Brod
Split
Varaždin
Zadar
Zagreb
Benátky nad Jizerou
Benešov
Bílovec
Brno
Brno-Lesna
Chrudim
Český Krumlov
Havlickux Brod
Hradec Králové
Hranice
Jindřichův Hradec
Kolín
Kroměříž
Mariánské Lázně
Mladá Boleslav
Náchod
Ostrava
Ostrava-Trebovice
Pardubice
Pilsen
Prague
Příbram
Řevnice
Semily
Slaný
Teplice
Trutnov
Ústí nad Labem
Aarhus N
Copenhagen
Esbjerg
Frederiksberg
Glostrup Municipality
Hellerup
Holbæk
Horsens
Haabneeme
Puusepa
Pärnu
Tallinn
Tartu
Jyväskylä
Kuopio
Lappeenranta
Oulu
Seinäjoki
Tampere
Abbeville
Amiens
Brest
Cambrai
Clamart
La Roche-sur-Yon
Lille
Lyon
Massy
Nantes
Paris
Pau
Pessac
Poitiers
Tours
Valenciennes
Altenburg
Aschaffenburg
Augsburg
Bad Nauheim
Berlin
Bochum
Cloppenburg
Cologne
Dortmund
Dresden
Essen
Frankfurt
Giengen an der Brenz
Görlitz
Großheirath
Hamburg
Heidelberg
Heilbronn
Homburg
Ingelheim
Kallstadt
Kassel
Kiel-Kronshagen
Leipzig
Ludwigshafen
Lübeck
Magdeburg
Mainz
Mannheim
Markkleeberg
München
Nienburg
Northeinm
Offenbach-beiber
Potsdam
Rüdersdorf
Siegen
Stuhr
Ulm
Unterschneidheim
Wardenburg
Wermsdorf
Weyhe
Witten
Woerishofen
Wuppertal
Athens
Larissa
Rhodes
Rio-Patras
Thessaloniki
Trikala
Voula
Ciudad
Clinica
Edificio Multimedica
Nivel
Oficina
Quetzaltenango
Zacapa
Ajka
Baja
Békéscsaba
Budapest
Debrecen
Hódmezővásárhely
Kecskemét
Keeskemet
Kistarcsa
Komárom
Makó
Nagykanizsa
Nyíregyháza
Pécs
Sopron
Szekszárd
Szombathely
Zalaegerszeg
Hyderabad
Vijayawada
Angamaly
Kochi
Thrissur
Ahmedabad
Anddhra Pradesh
Andhra Pradesh
Aurangabad
Bangalore
Bikaner
Chennai
Coimbatore
Delhi
Gujrāt
Indore
Jaipur
Karnataka
Kerala
Kolkata
Ludhiana
Madhya Pradesh
Maharashtra
Mangalore
Mumbai
Nagpur
Nashik
New Delhi
Pune
Punjab
Pūni
Rajasthan
Ramnagar
Shimoga
Surat
Trivandrum
Vadodara
Afula
Beersheba
Dimona
Giv‘atayim
Hadera
Haifa
Holon
Jerusalem
Kfar Saba
Nahariya
Nazareth
Petah Tikva
Poria – Neve Oved
Raanana
Rehovot
Tel Aviv
Tel Litwinsky
Ẕerifin
Bologna
Brescia
Cantania
Casarano
Caserta
Chieti
Cremona
Genova
Grosseto
Legnano
Manerbio
Milan
Monserrato
Napoli
Novara
Ostia Antica
Pavia
Pisa
Pozzuoli
Roma
Santa Maria Capua Vetere
Sassari
Seriate
Siena
Trieste
Venezia Mestre
Kyoto
Lida-shi
Ueda-shi
Minato-ku
Aichi
Aomori
Chiaki
Chiba
Ehime
Fukuoka
Fukushima
Gifu
Gunma
Hiroshima
Hokkai-do
Hokkaido
Hyōgo
Ibaraki
Isesaki-shi
Ishikawa
Kagawa
Kanagawa
Kumamoto
Kyoda
Mie
Miyagi
Nagaoka-shi
Nagasaki
Niigata
Numakunai
Okayama
Osaka
Saitama
Shimane
Shizuoka
Tokushima
Tokyo
Yamaguchi
Yokohama
Guadalajara
Xalapa
Aguascalientes
Chihuahua City
Distrito Federal
Durango
Monterrey
San Luis Potosí City
Yucatán
Almere Stad
Amstelveen
Amsterdam
Dordrecht
Eindhoven
Ewijk
Leiderdorp
Maastricht
Rotterdam
Venlo
Wildervlank
Lower Hutt
Auckland
Christchurch
Dunedin
Hamilton
Nelson
Tauranga
Bodø
Harstad
Haugesund
Oslo
Rud
Arequipa
Callao
Lima
Cebu
Cebu City
Davao City
Pasig
Quezon City
Ostrów
Bydgoszcz
Chojnice
Elblag
Ełk
Gdansk
Inowrocław
Jarosław
Katowice
Komenskiego
Kołobrzeg
Krakow
Kutno
Libiąż
Lodz
Lubartów
Lublin
Pomorskie
Puławy
Płock
Ruda Śląska
Rzeszów
Skierniewice
Sopot
Sucharskiego
Szczecin
Tarnów
Torun
Warsaw
Warzawa
Wroclaw
Amadora
Aveiro
Braga
Coimbra
Leiria
Lisbon
Ponta Delgada
Setúbal
Viseu
Bacau
Brasov
Brăila
Buccuresti
Bucharest
Buzău
Covasna
Dambovita
Iași
Judetul Maramures
Judetul Mures
Judetul Suceava
Judetul Vrancea
Oradea
Timișoara
Barnaul
Chelyabinsk
Kemerovo
Krasnoyarsk
Moscow
Nizhny Novgorod
Novosibirsk
Omsk
Orenburg
Perm
Ryazan
Saint Petersburg
Saratov
Smolensk
Tula
Tyumen
Volgograd
Voronezh
Yaroslavl
Belgrade
Kamenitz
Niš
Niška Banja
Zemun
Zmaj Jovina
Bardejov
Bratislava
Dolný Kubín
Galanta
Košice
Levice
Lučenec
Nitra
Nové Zámky
Prešov
Rimavská Sobota
Alberton
Benoni
Bloemfontein
Cape Town
Diepkloof
Durban
Lyttelton
Parktown West
Port Elizabeth
Potchefstroom
Pretoria
Somerset West
Worcester
Busan
Daegu
Daejeon
Gangwon-do
Gwangju
Gyeonggi-do
Incheon
Pusan
Seoul
A Coruña
Alcoy
Almería
Barcelona
Bilbao
De La Castellana
Donostia / San Sebastian
Figueras
Jaén
Lleida
Madrid
Murcia
Santiago de Compostela
Seville
Vigo
Vitoria-Gasteiz
Alingsås
Enköping
Gothenburg
Halmstad
Karlshamn
Köping
Lindesberg
Luleå
Lund
Malmo
Mora
Mölndal
Örebro
Skene
Umeå
Uppsala
Varberg
Lausanne
Lugano
Changhua
Hualien City
Kaohsiung City
Taichung
Taipei
Taoyuan
Yongkang District
Bangkok
Chang Mai
Khon Kaen
Nakhon Ratchasima
Pathum Thani
Sai Mai
Songkhla
Adana
Ankara
Antalya
Aydin
Erzurum
Eskişehir
Isparta
Istanbul
Izmir
Konya
Sivas
Cherkasy
Chernihiv
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Ivano-Frankivsh
Ivano-Frankivsk
Kharkiv
Kherson
Kyiv
Luhansk
Lutsk
Lviv
Mykolayiv
Odesa
Poltava
Uzhhorod
Vinnytsia
Zaporizhzhya
Birmingham
Blackpool
Bournemouth
Bradford
Cambridge
Chesterfield
Coventry
Devon
Dundee
East Horsley
East Sussex
Edinburgh
Essex
Glasgow
Harrow
Leicester
Liverpool
London
Middlesbrough
Orpington
Peterborough
Portadown
Sheffield
Stirling
Stockport
Surrey
Sutton Coldfield
Swindon
Warwickshire
Wolverhampton
York
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