Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma

PHASE3TerminatedINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

December 31, 2008

Primary Completion Date

February 29, 2012

Study Completion Date

June 30, 2012

Conditions
Anaplastic AstrocytomaGlioblastoma
Interventions
DRUG

trabedersen

DRUG

temozolomide

DEVICE

Drug delivery system for administration of AP 12009

Drug delivery system for Convection Enhanced Delivery consists of a portable pump (Pegasus vario or Pega vario) with drug reservoir (Pega Bag) and infusion line (Pega Line). Main implanted parts are the port access system (PORT-A-CATH) and the intratumoral catheter (Medtronic ventricular catheter).

PROCEDURE

Placement of Drug Delivery System

Surgery for placement of intratumoral catheter and subcutaneous port access system as per routine clinical practice. Stereotactical catheter placement controlled by CT.

DRUG

carmustine

DRUG

lomustine

Trial Locations (68)

114

Tri-Service General Hospital, Taipei

404

China Medical University Hospital, Taichung

407

Taichung Veterans General Hospital, Taichung

1090

AKH Wien, Klinik für Neurochirurgie, Vienna

6020

Universitätsklinik Innsbruck, Abteilung für Neurologie, Innsbruck

6720

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ, Szeged

11501

Winthrop University Hospital, Mineola

13385

La Timone University Hospital, Marseille

14050

Medica Sur, Mexico City

14642

University of Rochester Medical Center, Rochester

20246

Universitätklinikum Hamburg-Eppendorf, Klinik für Neurochirurgie, Hamburg

28041

Hospital Doce de Octubre, Madrid

30625

Medizinische Hochschule Hannover Neurochirurgische Klinik, Hanover

39008

Hospital Universitario Marqués de Valdecilla, Santander

39120

Otto-von-Guericke-Universität, Klinik für Neurochirurgie, Magdeburg

41013

Hospital Universitario Virgen del Rocío, Seville

44670

Hospital San Javier, Guadalajara

48149

Klinik und Poliklinik für Neurochirurgie, Münster

48903

Hospital de Cruces, Barakaldo

60528

Klinik und Poliklinik für Neurochirurgie, Frankfurt/M.

69120

Universitätsklinik Heidelberg Neurologische Klinik, Heidelberg

79106

Universitätsklinikum Freiburg, Freiburg im Breisgau

89312

Neurochirurgische Klinik an der Universität Ulm am Bezirkskrankenhaus Günzburg, Günzburg

93053

Klinik und Poliklinik für Neurologie, Regensburg

110029

All India Institute of Medical Sciences (AIIMS), New Delhi

115478

State Institution Russian Oncology Research Center N.N. Blokhin, Moscow

160012

Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh

191104

Russian Scientific Research Neurosurgical Institute A.L. Polenov, Saint Petersburg

194044

Military Medical Academy, Neurosurgery Dept, Saint Petersburg

226014

SGPGI of Medical Sciences, Lucknow

410210

Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Mumbai

443095

Samara Region Clinical Hospital M.I. Kalinin, Samara

454021

Chelyabinsk City Hospital #3; Department of Neurosurgery, Chelyabinsk

500034

Care Hospitals, Hyderabaad

560017

Manipal Hospital & Manipal Institute for Neurological Disorders, Bangalore

Amrita Institute of Medical Sciences Research Center, Kochi

560029

NIMHANS, Bangalore

560060

BGS Global Hospital, Bangalore

600006

Apollo Speciality Hospitals, Chennai

695011

SCTIMST, Dept. of Neurosurgery, Thiruvananthapuram

700029

AMRI Hospitals, Kolkata

08820

NJ Neuroscience Institute; JFK Medical Center, Edison

C1280AEB

Hospital Británico, Buenos Aires

C1428

FLENI, Buenos Aires

X5000JHQ

Sanatorio Allende, Córdoba

14784-400

Hospital de Câncer de Barretos, Barretos / SP

74223-080

Centro Goiano de Oncologia (CGO), Goiânia

99010-080

Hospital Sao Vicente de Paulo, Passo Fundo

90035-903

Hospital de Clínicas de Porto Alegre, Porto Alegre

90610-000

Hospital Sao Lucas da PUCRS, Porto Alegre

04038-034

Hospital do Servidor Público Estadual, São Paulo

G7H 7P2

ECOGENE-21 Centre d'études cliniques, Chicoutimi

AB T2N 2T9

Foothills Medical Centre, Calgary

H3A 2B4

Montreal Neurological Institute and Hospital, Montreal

04103

Universitätsklinikum Leipzig, Neurochirurgische Klinik, Leipzig

06120

Hospital General de Mexico, Mexico City

85-681

Wojskowy Szpital Kliniczny, Klinika Neurochirurgii, Bydgoszcz

80-952

Akademickie Centrum Kliniczne, Gdansk

91-153

SP ZOZ Uniwersytecki Szpital Kliniczny nr 1, Klinika Neurochirurgii, Lodz

20-090

Samodzielny Publiczny Szpital Kliniczny nr 4, Klinika Neurochirurgii i Neurochirurgii Dziecięcej, Lublin

41-200

Kliniczny Oddzial Neurochirurgii SUM w Sosnowcu Wojewódzki Szpital Specjalistyczny nr 5, Sosnowiec

02-781

Centrum Onkologii - Instytut Im. Marii Sklodowskiej-Curie, Warsaw

120-752

Severance Hospital, Yonsei University College of Medicine, Seoul

137-701

Kangnam St. Mary's Hospital, Seoul

138-736

Asan Medical Center, Seoul

08035

Hospital Universitario Vall d'Hebron, Barcelona

EH42XU

Edinburgh Centre for Neuro-Oncology, Western General Hospital, Edinburgh

WC1N 3BG

The National Hospital for Neurology and Neurosurgery, London

Sponsors
All Listed Sponsors
lead

Isarna Therapeutics GmbH

INDUSTRY