Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study

PHASE3CompletedINTERVENTIONAL
Enrollment

57

Participants

Timeline

Start Date

April 30, 2006

Primary Completion Date

December 31, 2008

Study Completion Date

August 31, 2013

Conditions
Tobacco Dependence
Interventions
DRUG

Placebo (sugar pill)

patients receive

DRUG

Topiramate

25 mg per day for one week, 50 mg per day for one week, 100 mg per day for one week, 200 mg per day for 5 weeks, then one week taper

DRUG

Nicotine patch

On the quit date (after 2 weeks of Topiramate medication use), subjects also use 21 mg patch for 7 weeks and on week 8 subjects received 14 mg/day for 3 days then 7 mg for 4 days.

Trial Locations (1)

06030

University of Connecticut Halth Center, Farmington

All Listed Sponsors
collaborator

National Center for Research Resources (NCRR)

NIH

collaborator

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIH

lead

UConn Health

OTHER

NCT00755716 - Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study | Biotech Hunter | Biotech Hunter