Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells for Dilated Cardiomyopathy

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

July 31, 2005

Primary Completion Date

June 30, 2006

Study Completion Date

June 30, 2008

Conditions
Dilated Cardiomyopathy
Interventions
PROCEDURE

intramyocardial bone marrow stem cells implantation

"Control group: the patients will be monitored with regular medical visits. Echocardiography: baseline,3,6,9 months. Cardiac NMR at baseline, 3 and 9 months.~Interventional group: Bone-marrow was collected from in the anterior-superior iliac crest and mononuclear stem cells were isolated by centrifugation in the density rate Ficoll-Hypaque 1.077 media. Technique - The approach was through a left mini-thoracotomy. Twenty small injections of cellular suspension were directly made through a 21F butterfly needle(total=5ml), in the anterior, lateral, posterior and apical faces of the LV ((average 9.6±2.6 x 10\[7\] cells). After the procedure, the patients were kept in the p.o. for a minimum period of 24hrs. They were released from the hospital in a period that varied from 5-7 days."

Trial Locations (1)

90620001

Institute of Cardiology of Rio Grande do Sul / FUC, Porto Alegre

All Listed Sponsors
collaborator

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil

OTHER

collaborator

Conselho Nacional de Desenvolvimento Científico e Tecnológico

OTHER_GOV

lead

Instituto de Cardiologia do Rio Grande do Sul

OTHER

NCT00743639 - Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells for Dilated Cardiomyopathy | Biotech Hunter | Biotech Hunter