2,067
Participants
Start Date
September 30, 2005
Primary Completion Date
April 30, 2013
Study Completion Date
April 30, 2013
Tocilizumab
For participants weighing \> 100 kg, the maximum dose of tocilizumab was 800 mg. Tocilizumab was supplied as a sterile solution in vials.
Disease-modifying anti-rheumatic drugs
Disease-modifying anti-rheumatic drugs included methotrexate, chloroquine, hydroxychloroquine, parenteral gold, sulfasalazine, azathioprine, and leflunomide. These drugs could be used alone or in combination, except for the combination of methotrexate and leflunomide, which was not allowed.
Non-steroidal anti-inflammatory drugs
Participants could be treated with non-steroidal anti-inflammatory drugs up to the maximum recommended dose throughout the study. The choice and doses of non-steroidal anti-inflammatory drugs were at the discretion of the investigator.
Oral corticosteroids
Oral corticosteroids (≤ 10 mg/day) were permitted during the study.
Lima
Lima
Reykjavik
Hong Kong
Tuenmen
Ljubljana
Lausanne
Diepkloof
Maribor
Radiokop
Sydney
Merksem
Lillehammer
Hellerup
Malvern
Hasselt
Cape Town
Durban
Woolloongabba
Shenton Park
Hobart
Pinelands
Cape Town
Levanger
New York
San José
Berlin
Bangkok
Bangkok
Belgrade
Great Neck
Plainview
Albany
Syracuse
Marseille
Binghamton
Mexico City
Orchard Park
Rochester
Pittsburgh
Santiago de Compostela
Genova
Duncansville
Stockholm
Danville
Bethlehem
Allentown
Niška Banja
Willow Grove
Philadelphia
Wyomissing
Newark
Milan
Wheaton
Frederick
Tijuana
Chesapeake
Norfolk
Brescia
Pavia
Raleigh
Durham
Madrid
Charlotte
Hickory Grove
Asheville
Málaga
Columbia
Charleston
Greenville
Brest
Atlanta
Haifa
Toulouse
Hildesheim
Panama City
Bordeaux
Udine
Aventura
Fort Lauderdale
West Palm Beach
Delray Beach
Tampa
Tampa
Sarasota
Montpellier
Haifa
Palm Habor
Palm Harbor
Padua
Panevezys
Rennes
Huntsville
Pontevedra
León
Nashville
Hixson
Grenoble
Jackson
Tupelo
Flowood
Gommern
Louisville
Lexington
Jyväskylä
Bowling Green
Saint-Priest-en-Jarez
Nantes
Cleveland
Guadalajara
Guadalajara
Herne
Canton
Cincinnati
Guadalajara
Essen
Dayton
Sendenhorst
Barakaldo
Lansing
Kalamazoo
Osnabrück
Grand Rapids
Kaunas
Chiang Mai
Des Moines
Cologne
Aachen
Cedar Rapids
Siena
Glendale
La Crosse
Eagan
Saint Louis Park
Pisa
Saint Cloud
Bismarck
Lille
Morton Grove
Vernon Hills
Springfield
St Louis
St Louis
St Louis
St Louis
Wiesbaden
Springfield
Strasbourg
Lincoln
Lyon
Pierre-Bénite
Rishon LeZiyyon
Slidell
Baton Rouge
Shreverport
Little Rock
Oklahoma City
Oklahoma City
Oklahoma City
Tulsa
Tulsa
Mesquite
Paris
Dallas
Paris
Rouen
Šiauliai
Houston
Ashkelon
Austin
Austin
Amarillo
Willow Grove
Amiens
München
Colorado Springs
München
Idaho Falls
Meridian
Boise
Mesa
Scottsdale
Paradise Valley
Scottsdale
Peoria
Tucson
Tucson
Albuquerque
Reno
Los Angeles
Los Angeles
Umeå
Torrance
Long Beach
Long Beach
Upland
San Diego
Boulogne-Billancourt
San Diego
Palm Desert
Palm Springs
Klaipėda
Anaheim
Santa Maria
Le Kremlin-Bicêtre
Palo Alto
San Leandro
San Jose
Würzburg
Eugene
Medford
Mountlake Terrace
Seattle
Seattle
Tacoma
Olympia
Spokane
Beijing
Beijing
Moscow
Moscow
Moscow
Saint Petersburg
Saint Petersburg
Shanghai
Shanghai
Hefei Anhui
Jinan
Tula
Ryazan
Guangzhou
Rio de Janeiro
Birmingham
Indianapolis
Portland
Boston
Pittsfield
Billings
Dover
Haddon Heights
Barcelona
New Brunswick
Passaic
Chapel Hill
Johnston
Dallas
Burlington
Buenos Aires
Buenos Aires
Rosario
San Juan Bautista
Campinas
Goiânia
Calgary
Edmonton
Victoria
Winnipeg
St. John's
Burlington
Hamilton
Kitchener
London
Mississauga
Ottawa
Toronto
Montreal
Québec
Sainte-Foy
Saskatoon
Hradec Králové
Prague
Prague
Helsinki
Nice
Dresden
Vilnius
Mexico City
Mexico City
Nijmegen
Lisbon
Ponce
Pretoria
Basingstoke
Birmingham
Cannock
Derby
Leeds
London
Manchester
Manchester
Middlesbrough
Newcastle upon Tyne
Oxford
Southampton
Stoke-on-Trent
Hoffmann-La Roche
INDUSTRY