172
Participants
Start Date
May 31, 2006
Primary Completion Date
August 31, 2011
Study Completion Date
September 30, 2011
CGC-11047 and gemcitabine
Gemcitabine: (Closed to enrollment) 1,000 mg/m2 administered IV over 30 minutes on Days 1, 8 and 15 of a 28-day cycle. CGC-11047 will only be given on days 1 and 15 of each cycle and will start at dose level -1 (50 mg).
CGC-11047 and docetaxel
Docetaxel: (Closed to enrollment) 75 mg/m2 administered IV over 60 minutes every 21 days. CGC-11047 will be administered only on Day 1 of each 21-day cycle and will start at dose level -1 (50 mg).
CGC-11047 and bevacizumab
Bevacizumab: 5 mg/kg administered IV once every 14 days. CGC-11047 will be administered on Days 1, 8 and 15 of a 28 day cycle.
CGC-11047 and erlotinib
Erlotinib: 150 mg taken orally every day of each 28-day cycle. CGC-11047 will be administered on Days 1, 8 and 15 of a 28 day cycle.
CGC-11047 and cisplatin
Cisplatin: 80 mg/m2 administered IV over 1 hour once every 28 days. CGC-11047 will be administered on Days 1, 8 and 15 of a 28 day cycle.
CGC-11047 and 5-flurouracil / leucovorin
5-Flurouracil / Leucovorin: Leucovorin 500 mg/m2 IV over 2 hours with 5 - FU 500 mg/m2 IV bolus starting 1 hour into leucovorin infusion weekly for 6 wks, repeated every 56 days. CGC-11047 will be administered on Days 1, 8 and 15 of a 28 day cycle.
CGC-11047 and sunitinib
Sunitinib: 50 mg orally once daily, 4 weeks on treatment followed by 2 weeks off (42 day cycle). CGC-11047 will be administered on Days 1 and 8 of a 21 day cycle.
New York Oncology Hematology PC, Albany
Virginia Oncology Associates, Norfolk
Cancer Centres of the Carolinas, Greenville
Cancer Centres of Florida, Ocoee
Dayton Oncology and Hematology, PA, Kettering
Central Indiana Cancer Centres, Indianapolis
Texas Oncology, PA, Dallas
Tyler Cancer Centre, Tyler
Comprehensive Cancer Centres of Nevada, Las Vegas
Northwest Cancer Specialists - Vancouver Cancer Centre, Vancouver
North Star Lodge Cancer Centre, Yakima
Rocky Mountain Cancer Centre, Denver
Lead Sponsor
Progen Pharmaceuticals
INDUSTRY