High-Dose Therapy Treatment in Patients With Follicular Lymphoma

PHASE3CompletedINTERVENTIONAL
Enrollment

172

Participants

Timeline

Start Date

June 30, 1994

Primary Completion Date

May 31, 2003

Study Completion Date

May 31, 2006

Conditions
Follicular Lymphoma
Interventions
PROCEDURE

chemotherapy

injection cyclophosphamide doxorubicin (25 mg/m2), and teniposide (60 mg/m2)(600 mg/m2)on day 1 and prednisone (40 mg/m2), administered orally on days 1 to 5.4,12 Treatment consisted of a 6-course induction phase administered monthly, followed, for responders and patients presenting a stable disease, by a maintenance phase that consisted of 1 cycle every 2 months for 1 year. Concomitant subcutaneous interferon alfa-2b was administered at 5 x 106 3 times a week for 18 months.

PROCEDURE

high dose therapy and autologous stem cell transplantation

VCAP regimen 3 cycles , less than PR: 2-3 DHAP, stem cell collection, in vitro purging autologous stem cell transplantation with TBI and cyclophosphamide

Trial Locations (2)

37000

Emmanuel GYAN, Tours

Philippe COLOMBAT, Tours

All Listed Sponsors
lead

French Innovative Leukemia Organisation

OTHER