1,623
Participants
Start Date
August 21, 2008
Primary Completion Date
July 14, 2016
Study Completion Date
July 14, 2016
Lenalidomide and low-dose dexamethasone
"Lenalidomide - oral, 2.5mg, 5mg, 10mg, 15mg 20mg, or 25 mg capsules, given either days 1-21 of each 28 day cycles or given every other day for 21 days until documentation of PD.~Dexamethasone - oral 4mg tablets for a total dose of 20mg or 40 mg given days 1,8,15 and 22 of each 28 day cycle up to disease progression"
Lenalidomide plus low-dose dexamethasone given for 18 four-week cycles
"lenalidomide - oral, 2.5mg, 5mg, 10mg, 15mg, 20 mg or 25 mg capsules given on days 1-21 of each 28 day cycle or every other day for 21 days for 18 cycles.~Dexamethasone - oral 4mg tablets for a total dose of 20mg or 40 mg given days 1,8,15 and 22 of each 28 day cycle for 18 cycles"
Melphalan, Prednisone and Thalidomide
Melphalan - oral, 2mg tablets dosed at either 0.25mg/kg, 0.125 mg/kg, 0.20mg/kg or 0.10mg/kg on days 1-4 of each 42 day cycle up to 12 cycles Prednisone - oral, 5mg, 10mg, 20 mg and 50 mg tablets dosed at 2mg/kg daily days 1-4 of each 42 day cycle for up to 12 cycles Thalidomide - oral, 50mg, 100mg and 200 mg capsules dosed at either 100mg or 200 mg daily on days 1-41 of each 42 day cycle for up to 12 cycles
Mater Misercordiae Hospital, Dublin
Adelaide and Meath Hospital, Dublin
Attiko Hospital of Athens, Athens
Jules Bordet Institut, Brussels
Centre Hospitalier Universitaire Vaudois CHUV, Lausanne
Hospital of the Barmherzigen Bruder Vienna, Vienna
Auckland City Hospital, Auckland
Hopital Erasme, Brussels
AZ-VUB, Brussels
MM-015.Wihelminenspital, Vienna
Cliniques Universitaires St-Luc, Brussels
Royal North Shore Hospital, St Leonards
ZNA Stuivenberg Centrumziekenhuis, Antwerp
Westmead Hospital, Wentworthville
Gosford Hospital, Gosford
Wollongong Hospital, Wollongong
Universitair Ziekenhuis Antwerpen, Edegem
Universitair Ziekenhuis Leuven, Campus Gasthuisberg, Leuven
Peter MacCallum Cancer Centre Divsion of Haematology Medical Oncology, East Melbourne
Inselsspital Bern, Bern
Western Hospital, Footscray
The Royal Melbourne Hospital, Parkville
Hospital St. Polten, Sankt Pölten
Cabrini Hospital, Malvern
Frankston Hospital, Frankston
Geelong Hospital, Geelong
Virga Jesse Ziekenhuis, Hasselt
Border Medical Oncology, Wodonga
Hospital of Barmherzige Schwestern Linz, Linz
Hospital of Elisabethinen Linz, Linz
General Hospital Linz, Linz
Royal Brisbane and Women's Hospital, Herston
UniversitatsSpital Basel, Basel
Princess Alexandra Hospital, Woolloongabba
Gold Coast Hospital, Southport
Hospital Wels, Wels
Royal Adelaide Hospital, Adelaide
Abteilung Onkologie Haematologie des Kantonsspitals Aarau, Aarau
MM-015. Salzburger Landkliniken, St. Johanns-Spital, Universitätsklinik fur Innere Medizin III, Salzburg
Flinders Medical Centre, Bedford Park
Cliniques Universitaires UCL de Mont-Godine, Yvoir
Royal Perth Hospital, Perth
Wellington Hospital, Newtown
Les Cliniques du Sud Luxembourg, Arlon
Kantonsspital Graubunden, Chur
Hospital Son Llatzer, Palma de Mallorca
AZ St-Jan Brugge Oostende AV, Bruges
Christchurch Hospital, Christchurch
Kantonsspital Winterthur, Winterthur
Kantonsspital Munsterlingen, Münsterlingen
Hospital Leoben, Leoben
H. Hartziekenhuis Roeselare-Menen vzw campus Wilgenstraat, Roeselare
Hospital Universitari Germans Trias i Pujol, Badalona (Barcelona)
UZ Gent, Ghent
National Taiwan University Hospital, Tapei
Ospedale Molinette, Torino
Arena Oncology Associates, PC, Lake Success
Veteran General Hospital - Taipei, Taipei
Alexandra Hospital, University of Athens, Athens
CHG Rodez, Rodez
Institut Paoli-Calmettes, Marseille
Hospital Reina Sofia, Córdoba
CHU, Caen
Centre Francois Baclesse, Caen
Hospital Clinico Santiago de Compostela, Santiago de Compostela
Clinica Ematologica, A.O.U. San Martino di Genova, Genova
Hospital Univ. Josep Trueta, Girona
Ernst-Moritz-Arndt-Universität Greifswald, Greifswald
Medizinische Fakultat der Universitat Rostock, Rostock
St. Luke's Hospital and Health Network, Allentown
Metaxa Hospital Peiraias, Piraeus
University of Pennsylvania, Philadelphia
Hospital de Donosti, Donostia / San Sebastian
Askepios Klinik St. Georg, Hamburg
U.O. di Ematologia e Trapianto di Midollo Osseo, Milan
Istituto Europeo di Oncologia - IEO, Milan
Presidio Ospedaliero A. Perrino, Milan
Center for Cancer and Blood Disorders, Bethesda
CHRU Hopital du bocage, Dijon
Centre Hospitalier Yves Le Foll, Saint-Brieuc
Universitatsklinikum schleswig-Holstein, Lübeck
Policlinico San Matteo Universita Di Pavia, Pavia
Hospital Clinico San Carlos, Madrid
Hospital 12 de Octubre, Madrid
Hospital Universitario La Paz, Madrid
Hospital Clinico Virgen de la Victoria, Málaga
Ospedale Civile, Piacenza
Hopital Augustin Morvan, Brest
Hospital General Universitario Morales Messeguer, Murcia
Clinica Universitaria de Navarra,, Pamplona
Integrated Community Oncology Network, Orange Park
Baptist Cancer Institute, Jacksonville
Gainesville Heme Oncology Associates, Gainesville
Institut Bergonie Centre Regional de Lutte Contre Le Cancer de Bordeaux Et Sud Ouest, Bordeaux
Polyclinique Bordeaux Nord Aquitaine, Bordeaux
Palm Beach Cancer Institute, LLC, West Palm Beach
CHRU - Hopital du Haut Leveque, Pessac
Gulf Coast Oncology, St. Petersburg
CHU Montpellier - Hôpital Lapeyronie, Montpellier
CHRU Hôpital de Pontchaillou, Rennes
CHRU Hopital sud Medecine Interne, Rennes
University of AL Birmingham, Birmingham
Universitatsklinikum Giessen, Giessen
CHRU Hopital Bretonneau, Tours
CHRU Hopital Trousseau, Tours
The Cancer Center, Collierville
Institut Prive de Cancerologie, Grenoble
CHRU, Grenoble
University of Tennessee Cancer Institute, Memphis
Hospital Universtario Marques de Valdecilla, Santander
Policlinico S. Orsola, Bologna
Universitaetsklinikum Dusseldorf Klinik fuer Haematologie, Düsseldorf
China Medical University Hospital, Taichung
Centre Hospitalier, Blois
Policlinico di Modena, Modena
Arcispedale Santa Maria Nuova, Reggio Emilia
Institut de Cancerologie de Loire, Saint-Priest-en-Jarez
Hospital Sant Pau, Reus
CHRU - Hotel Dieu, Nantes
University Hospitals of Cleveland, Cleveland
Cleveland Clinic, Cleveland
Gabrail Cancer Center Research, Canton
CH La Source, Orléans
Universitatsklinikum Essen-, Essen
Hosptial La Fe, Valencia
Hospital Clinico Universitario de Valencia, Valencia
Poliklinik A, Münster
CHRU Hopital du bocage, Angers
Hospital Clinico Universitario Lozano Blesa, Zaragoza
Hospital Miguel Servet, Zaragoza
Hopital R. Debre, Reims
CHU Reims - Hôpital Maison Blanche, Reims
CHRU Hôpitaux de Brabois, Vandœuvre-lès-Nancy
Mayo Clinic Cancer Center, Rochester
CH P. Chubert, Vannes
A.O. Universitaria Ospedale S.Chiara Dip.Oncologia, Div. Ematologia, Pisa
Hopital de Mercy, Metz
Dakota Cancer Institute, Fargo
GH de Institut Catholique St Vincent, Lille
CHRU-Hopital Claude Huriez, Lille
Billings Clinic, Billings
Centre Hospitalier General, Dunkirk
Orchard Healthcare Research, Inc., Chicago
John H Stroger Hospital of Cook County, Chicago
Rush University Medical Center, Chicago
Southern Illinois Hematology Oncology, Centralia
Chu Estaing, Clermont-Ferrand
Centre Hospitalier de la cote basque, Bayonne
Staedtische Kliniken Frankfurt am Main Hochst, Frankfurt am Main
CHRU Hôpital de Hautepierre, Strasbourg
Cancer Center of Kansas, Wichita
Hopital Emile Muller, Mulhouse
CH Louis Pasteur, Colmar
Centre Leon Berard, Lyon
CHU Hopital Edouard Herriot, Lyon
Centre Hospitalier de Valence, Lyon
Centre Hospitalier William Morey, Chalon/Saone Cedex
Centre Jean Bernard, Le Mans
Centre Hospitalier, Le Mans
Medizinische Klinik - Abteilung II, Tübingen
Ematologia ed Immunologia, Azienda Ospedaliera Vito Fazzi di Lecce, Lecce
Hopital Saint Louis, Paris
Hopital Necker, Paris
Unità Operativa di Oncoematologia, Ospedale di Matera, Matera
CHU Hôpital St-Antoine, Paris
Hopital Cochin, Paris
Hopital J MonodRhumato Nord, Le Havre
Centre Henri Becquerel, Rouen
CH, Le Chesnay
CHU Sud, Amiens
Oncoematologia, Istituto Nazionale Tumori Fondazione G. Pascale, Napoli
Clinique Claude BernardOncologie, Albi
Klinikum der Johann-Wolfgang-Goethe-Universtat, München
Medizinische Klinik III Klinikum der Universität München-Großhadern, München
Clinique Pont de chaume Oncologie et Radiotherapie, Montauban
Centre Hospitalier Departemental, La Roche-sur-Yon
CU CHU Clemenceau, Poitiers
CH - Hôpital Dupuytren, Limoges
Oncologia Medica, Università della Magna Grecia, Catanzaro
Klinik fur Innere Medizin III, Ulm
Cedar Sinai Medical Center Dept of Medicine, Los Angeles
Casa di Cura La Maddalena, Divisione di Ematologia, Palermo
Hopital Antoine Beclere, Clamart
Hopital dinstruction des armees Percy, Clamart
Centre Rene Huguenin, Saint-Cloud
Hopital Avicenne, Bobigny
Hopital Henri Mondor, Créteil
University of California, San Francisco- California, San Francisco
Stanford University Stanford, Stanford
Institut Gustave Roussy, Villejuif
CH Argenteuil Victor Dupouy, Argenteuil
CH Rene Dubois, Cergy-Pontoise
Kaiser Permanente Northwest Oncology Hematology, Portland
Swedish Cancer Institute, Seattle
Fred Hutchinson Cancer Center, Seattle
Chaoyang Hospital, Beijing
Peking University People's Hospital, Beijing
Ruijin Hospital Shanghai Jiaotong University, Shanghai
Blood Disease Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin
West China Hospital of Sichuan University, Chengdu
Kremlin Bicetre, Le Kremlin-Bicêtre
Ingalls Cancer Institute, Harvey
Maine Center for Cancer Medicine Blood Disorders, Scarborough
University of Texas Medical Branch, Galveston
MM-015. Medizinische Universität Wien, Vienna
Hospital Wiener Neustadt, Wiener Neustadt
Evangelismos Hospital of Athens, Athens
University of Athens, Athens
Hospital de Sao Marcos, Braga
Hospital de Santo Antonio- Porto, Porto
University of Calgary, Calgary
Cross Cancer Institute, Edmonton
British Columbia Cancer Agency, Kelowna
Royal Columbian Hospital, New Westminster
BC Cancer Agency - Fraser Valley Centre, Surrey
Leukemia/BMT Program of BCDiv of Hem, Vancouver Gen Hosp, Vancouver
Vancouver Island Cancer Center, Victoria
Saint John Regional Hospital, Saint John
Queen Elizabeth II Health Sciences Center, Halifax
Juravinski Cancer Centre, Hamilton
London Health Science Centre, London
Ottawa Hospital, Ottawa
Odette Cancer Centre, Toronto
Princess Margaret Hospital, Toronto
Hospital Charles LeMoyne, Greenfield Park
Hopital de la Cite-de-la-Sante, Laval
Hotel-Dieu de Levis, Lévis
Hopital du Sacre-Coeur de Montreal, Montreal
Hospital Maisonneuve - Rosemont, Montreal
CHUM- Hopital Notre-Dame, Montreal
McGill University, Montreal
Sir Mortimer B. Davis - Jewish Genl, Montreal
CHUQ - Hotel-Dieu de QuebecHematology - Oncology, Québec
Hopital de Fleyriat, Bourg-en-Bresse
CH, Cannes
Centre Antoine Lacassagne Oncologie medicale et Hematologie, Nice
Hopital de lArchet 1, Nice
CHRU Hopital Purpan, Toulouse
Medizinische Kinik und Poliklinik I, Dresden
Universitatsklinikum Jena, Jena
Medizinische Klinik und Poliklinik II, Leipzig
Zentrum F. Innere Medizin II Robert- Bosch-Krankenhaus GmBH, Stuttgart
Theagenio Anticancer Hospital of Thessaloniki, Thessaloniki
University Hospital Galway, Galway
Istituto Nazionale Tumori Regina Elena, Struttura Complessa Ematologia ed Unita di Cellule Staminali, Roma
Azienda Policlinico Umberto I, Universita La Sapienzadi Roma, Rome
Hospitais da Universidade de Coimbra, Coimbra
Instituto Portugues de Oncologia de Lisboa, Lisbon
Hospital de Santa Maria, Lisbon
Instituto Português de Oncologia Porto, Porto
Hallym University Sacred Heart Hospital, Anyang
Inje University Busan Paik Hospital, Busan
Daegu Catholic University Medical Center 3056-6, Daegu
Chungnam National University Hospital, Daejeon
National Cancer Center, Gyeonggi-do
Hwasun Chonnam National University Hospital, Hwasun-goon
Gachon University Gil Hospital, Incheon
Chonbuk National University Hospital 42, Jeonju
Seoul National University Bundang Hospital, Seongnam
Severance Hospital, Seongsanno
Seoul National University Hospital, Seoul
Samsung Medical Center, Seoul
The Catholic University of Korea Seoul - Saint Mary's Hospital, Seoul
Asan Medical Center, Seoul
Ewha Womans University Mokdong Hospital, Seoul
Hospital de la Santa Creu i Sant Pau, Barcelona
Instituto Catalan de Oncologia-Hospital Duran, Barcelona
Linkoping University Hospital, Linköping
Karolinska University HospitalSolna, Stockholm
St. Görans Hospital, Stockholm
Karolinska University Hospital Huddinge, Stockholm
Gwynedd Hospital, Bangor
Royal United Hospital, Bath
Belfast City Hospital Haematology Department, Belfast Northern Ireland
Birminghman QE, Birmingham West Midlands
Royal Bournemouth Hosp, Bournemouth Dorset
Bristol Haematology and Oncology Centre, Bristol
Addenbrooke's Hospital, Cambridge
University Hospital of Wales - Cardiff, Cardiff
The Beatson West of Scotland Centre, Glasgow
Dept of Haematology St Bartholomews Hospital, London
Guy's and St Thomas' Hospital - London, London
Royal Free Hospital, London
Churchhill Hospital, Oxford
Derriford Hospital, Plymouth Crownhill Devon
Royal Hallamshire Hospital Sheffield Teaching Hospitals NHS Trust, Sheffield
Pinderfields General Hospital, West Yorkshire
New Cross Hospital- Wolverhampton, Wolverhampton
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