Study to Test the Long Term Safety and Efficacy of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder

PHASE3CompletedINTERVENTIONAL
Enrollment

2,792

Participants

Timeline

Start Date

April 25, 2008

Primary Completion Date

May 6, 2010

Study Completion Date

May 6, 2010

Conditions
Urinary Bladder, Overactive
Interventions
DRUG

Mirabegron

Tablets

DRUG

Tolterodine

Extended release capsules

DRUG

Placebo to Mirabegron

Matching mirabegron placebo tablets.

DRUG

Placebo to Tolterodine

Matching tolterodine placebo capsules.

Trial Locations (308)

101

Reykjavik

1047

Budapest

1076

Budapest

2020

Antwerp

2030

Antwerp

2317

Hamar

2600

Glostrup Municipality

2650

Edegem

2700

Amadora

2800

Tatabánya

3000

Leuven

3016

Drammen

3103

Tønsberg

3800

Sint-Truiden

4000

Liège

4020

Linz

4400

Nyíregyháza

5021

Bergen

6000

Lucerne

6020

Innsbruck

6725

Szeged

7100

Szekszárd

8000

Székesfehérvár

8036

Graz

8200

Aarhus

8304

Mataró

8500

Kortrijk

8501

Frauenfeld

8900

Leper

9000

Ghent

9100

Aalborg

10016

New York

11530

Garden City

11883

Sonkoping

12205

Albany

12208

Albany

12401

Kingston

12601

Poughkeepsie

12851

Prague

13274

Marseille

13347

Berlin

13760

Endwell

14056

Prague

14186

Stockholm

15401

Uniontown

16128

Genoa

16151

Oranienburg

16761

Henningsdorf

17176

Stockholm

17604

Lancaster

18081

Prague

18288

Stockholm

19004

Bala-Cynwyd

19046

Jenkintown

19230

Hagenow

19611

Reading

20100

Turku

20142

Milan

20253

Hamburg

20770

Greenbelt

21100

Varese

22328

Bucharest

23454

Virginia Beach

24047

Treviglio

25436

Uetersen

27103

Winston-Salem

27518

Cary

27601

Mělník

27777

Ganderkesee

28016

Madrid

28025

Concord

28046

Madrid

28209

Charlotte

28401

Wilmington

28905

Getafe

29464

Mt. Pleasant

29650

Greer

29681

Simpsonville

30029

Nîmes

30034

Decatur

30060

Marietta

30076

Roswell

30328

Atlanta

30599

Pilsen

31059

Toulouse

32308

Tallahassee

32803

Orlando

33024

Pembroke Pines

33027

Pembroke Pines

33136

Miami

33180

Aventura

33407

West Palm Beach

33414

Wellington

33521

Tampere

33606

Tampa

33756

Clearwater

33761

Clearwater

33916

Fort Myers

34237

Sarasota

34471

Ocala

35209

Homewood

35801

Huntsville

36117

Montgomery

36608

Mobile

37620

Bristol

40001

Ústí nad Labem

41013

Seville

41100

Modena

41108

Štětí

42055

Saint-Priest-en-Jarez

43214

Columbus

44122

Cleveland

44124

Lyndhurst

44281

Wadsworth

45067

Orléans

45071

Toledo

45212

Cincinnati

46010

Valencia

46825

Fort Wayne

47051

Duisburg

47130

Jeffersonville

47630

Newburgh

48013

Bilbao

50309

Des Moines

54130

Skövde

54290

Trier

56068

Koblenz

56130

Bad Ems

57207

Wichita

58104

Fargo

59102

Billings

60160

Melrose Park

60200

Brno

64116

North Kansas City

65933

Frankfurt

67000

Strasbourg

68024

Colmar

68070

Mulhouse

68114

Omaha

68516

Lincoln

70124

Bari

70185

Örebro

70853

Ostrava-Poruba

73008

Bethany

Edmond

73034

Edmond

75020

Paris

75185

Huddinge

75231

Dallas

75571

Paris-Cedex12

76017

Arlington

77024

Houston

77200

Olomouc

78414

Corpus Christi

78759

Austin

80012

Aurora

80112

Englewood

80131

Naples

80211

Denver

80218

Denver

81925

Muenchen-Bogenhausen

83404

Idaho Falls

83814

Coeur d'Alene

84107

Salt Lake City

85051

Phoenix

85712

Tucson

85741

Tucson

86551

Aichach

87109

Albuquerque

88100

Catanzaro

89148

Las Vegas

90185

Umeå

90211

Beverly Hills

90220

Oulu

90505

Torrance

90620

Buena Park

90982

Skalica

91101

Trenčín

91345

Mission Hills

91356

Tarzana

91942

La Mesa

92108

San Diego

92120

San Diego

92404

San Bernardino

92660

Newport Beach

92869

Orange

93720

Fresno

94027

Atherton

95831

Sacramento

98043

Mountlake Terrace

98166

Seattle

98405

Tacoma

99204

Spokane

99508

Anchorage

101000

Moscow

105425

Moscow

111020

Moscow

111123

Moscow

115516

Saint Petersburg

117049

Moscow

117815

Moscow

119435

Moscow

123836

Moscow

125206

Moscow

197089

Saint Petersburg

198013

Saint Petersburg

220036

Minsk

223041

Minsk

06052

New Britain

06708

Waterbury

02472

Watertown

08901

New Brunswick

07052

West Orange

02886

Warwick

Unknown

Woolloongabba

Montreal

Roskilde

Kiel

Munich

Sopron

Dublin

Mullingar

Liepāja

Riga

Kaunas

Warsaw

Bucharest

Lasi

Oradea

Hatfield

Lyttelton

Paarl

Pietermaritzburg

Roodepoort

T2V 4R6

Calgary

T5H 3V9

Edmonton

V3V 1N1

Surrey

V8T 5G1

Victoria

V8V 3N1

Victoria

E2L 3J8

Saint John

B2W 2S7

Dartmouth

B4N 4K9

Kentville

L4M 7G1

Barrie

L6T 4S5

Brampton

N2N 2B9

Kitchener

L6B 1A1

Markham

L3X 1W1

Newmarket

P1B 7K8

North Bay

L1H 1B9

Oshawa

H2X 3J4

Saint Denis

P7E 6E7

Thunder Bay

M4N 3M5

Toronto

M5T 2S8

Toronto

J2G 8Z9

Granby

H3A 1A1

Montreal

H9R 4S3

Point Claire

00029

Helsinki

02625

Bautzen

06295

Eisleben Lutherstadt

06132

Halle

06333

Hettstedt

04105

Leipzig

01844

Neustadt in Sachsen

01445

Radebeul

06526

Sangerhausen

04100

Latina

06122

Perugia

1105 AZ

Amsterdam

7334 DZ

Apeldoorn

5623 EJ

Eindhoven

7511 JX

Enschede

2334 CK

Leiden

6532 SZ

Nijmegen

8600 BA

Sneek

5022 GC

Tilburg

7101 BN

Winterswijk

0257

Oslo

15-278

Bialystok

93-338

Lodz

93-513

Lodz

20-954

Lublin

00-846

Warsaw

02-005

Warsaw

02-507

Warsaw

50-556

Wroclaw

4099-005

Porto

2304-909

Tomar

03659

Martin

05801

Poprad

01207

Žilina

08020

Barcelona

08036

Barcelona

09200

Miranda de Ebro

01023

Kiev

04053

Kiev

B15 2TG

Bristol

PR7 7NA

Chorley

CR7 7YE

Croydon

L22 OLG

Liverpool

SE5 9RS

London

W2 2YP

London

M15 6SX

Manchester

NE7 7DN

Newcastle upon Tyne

HA6 2RN

Northwood

RG1 5AN

Reading

RG2 7AG

Reading

S10 2JF

Sheffield

SA6 6NL

Swansea

Sponsors
All Listed Sponsors
lead

Astellas Pharma Inc

INDUSTRY

NCT00688688 - Study to Test the Long Term Safety and Efficacy of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder | Biotech Hunter | Biotech Hunter