250
Participants
Start Date
February 28, 2007
Primary Completion Date
June 30, 2011
Study Completion Date
September 30, 2011
topiramate
"topiramate powder 0mg - 150 mg with lactate in blind capsules. Two capsules dispensed daily. One capsule ingested under supervision at the methadone window. One capsule to be ingested at home at bedtime. Participant is expected to return the empty blister pack on the following day.~capsules are administered from week 4 through 25 of the trial"
Contingency Reinforcement
monetary reward for self-reported cocaine abstinence confirmed by urine toxicology results
placebo + NonCR
participant receives placebo capsules and monetary reinforcers by chance, irrespective of cocaine use or abstinence
Behavioral Pharmacology Research Unit, Baltimore
National Institute on Drug Abuse (NIDA)
NIH
Johns Hopkins University
OTHER