Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

723

Participants

Timeline

Start Date

September 3, 2008

Primary Completion Date

August 31, 2010

Study Completion Date

February 25, 2016

Conditions
Kidney Neoplasms
Interventions
DRUG

Axitinib (AG-013736)

axitinib will be given at a starting dose of 5 mg twice daily \[BID\] with continuous dosing

DRUG

Sorafenib

sorafenib will be given at a dose of 400 mg twice daily \[BID\] with continuous dosing

Trial Locations (294)

100

Department of Oncology, National Taiwan University Hospital, Taipei

333

Chang Gung Medical Foundation-Linkou Branch, Taoyuan District

407

Taichung Veterans General Hospital, Department of Surgery, Taichung

833

Chang Gung Medical Foundation-Kaohsiung Branch, Kaohsiung Hsien

1020

Med. Abt. KH Barmherzige Brueder Wien, Krankenhaus der Barmherzigen Brueder Wien, Vienna

2605

The Canberra Hospital, Medical Oncology, Garran

3002

Peter MacCallum Cancer Centre, East Melbourne

3081

Heidelberg Repatriation Hospital, Austin Health, Heidelberg West

3084

Austin Hospital, Austin Health, Heidelberg

3350

Ballarat Oncology & Haematology Services, Ballarat

5037

Ashford Cancer Centre Research, Kurralta Park

10065

Memorial Sloan Kettering Cancer Center - Sidney Kimmel Center, New York

Memorial Sloan Kettering Cancer Center, New York

10466

Montefiore Medical Center, The Bronx

12200

Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin

13126

Department of Medicine MSG @ SUNY HSC @ Syracuse, Inc., Oswego

13210

Department of Medicine MSG @ SUNY HSC @ Syracuse, Inc, Syracuse

13273

Institut Paoli-Calmettes, Marseille

13421

Department of Medicine MSG @ SUNY HSC @ Syrcacuse, Inc., Oneida

16132

UOC Oncologia Medica B, IRCCS AO Universitaria San Martino, Genova

20007

Georgetown University Hospital, Lombardi Cancer Center, Washington D.C.

Georgetown University Medical Center, Washington D.C.

20089

UO di Oncologia ed Ematologia, Istituto Clinico Humanitas, Rozzano (MI)

20133

Fondazione IRCCS, Istituto Nazionale dei Tumori, SC Oncologia Medica 2, Milan

20155

Virginia Cancer Specialists, PC, Gainesville

20176

Virginia Cancer Specialists, PC, Leesburg

22031

Virginia Cancer Specialists, PC, Fairfax

22191

Virginia Cancer Specialists, PC, Woodbridge

22205

Virginia Cancer Specialists, PC, Arlington

23320

Virginia Oncology Associates, Chesapeake

23456

Virginia Oncology Associates, Virginia Beach

23502

Virginia Oncology Associates, Norfolk

23606

Virginia Oncology Associates, Newport News

23666

Virginia Oncology Associates, Hampton

25123

Azienda Ospedaliera Spedali Civili di Brescia, Unita' Operativa Oncologia Medica, Brescia

26100

Struttura Complessa di Oncologia, Cremona

26133

Klinikum Oldenburg gGmbH, Klinik fuer Innere Medizin II Onkologie / Haematologie, Oldenburg

27100

IRCCS Policlinico San Matteo, Pavia

27518

Raleigh Hematology Oncology Associates, DBA, Cary

27607

Raleigh Hematology Oncology Associates, P.C., Raleigh

27710

Duke University Medical Center, Durham

Investigational Chemotherapy Services, Durham

27909

Albermarie Hospitals, Elizabeth City

Virginia Oncology Associates, Elizabeth City

28034

Hospital Universitario Ramon Y Cajal, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

29010

Hospital Clinico Universitario Virgen de La Victoria, Málaga

29307

Cancer Centers of the Carolinas, Spartanburg

29425

Medical University of South Carolina, Charleston

29605

Cancer Centers of the Carolinas, Easley

Cancer Centers of the Carolinas, Greenville

29615

Hematology and Oncology Associates of SC, LLC - Eastside Medical Center, Greenville

29672

Cancer Centers of the Carolinas, Seneca, Seneca

30318

Peachtree Hematology-Oncology Consultants, P.C., Atlanta

30449

Klinikum Region Hannover Krankenhaus Siloah, Hanover

30736

Chattanooga Oncology and Hematology Associates, PC, Ringgold

31008

Clinica Universitaria de Navarra, Pamplona

Hospital de Navarra, Pamplona

32806

M.D. Anderson Cancer Center Orlando, Orlando

Orlando Regional Medical Center, Orlando

33075

Hopital Saint-André, Bordeaux

33081

Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano (PN)

Dipartimento dei laboratori diagnositici e per le terapie cellulari, Aviano (PN)

33136

University of Miami Hospital and Clinics, Miami

33442

University of Miami Sylvester at Deerfield Beach, Deerfield Beach

33901

Florida Cancer Specialists, Fort Myers

33905

Florida Cancer Specialists, Fort Myers

33908

Florida Cancer Specialists, Fort Myers

33914

Florida Cancer Specialists, Cape Coral

33916

Florida Cancer Specialists, Fort Myers

33980

Florida Cancer Specialists, Port Charlotte

33990

Florida Cancer Specialists, Cape Coral

34102

Florida Cancer Specialists, Naples

34119

Florida Cancer Specialists, Naples

34135

Florida Cancer Specialists, Bonita Springs

34209

Florida Cancer Specialists, Bradenton

34223

Florida Cancer Specialists, Englewood

34232

Florida Cancer Specialists, Sarasota

34236

Florida Cancer Specialists, Sarasota

34285

Florida Cancer Specialists, Venice

34292

Florida Cancer Specialists, Venice

35042

Centre Eugene Marquis, Rennes

35128

Unita' Operativa Oncologia Medica 2, Regione del Veneto, Padua

37044

CHRU de Tours - Hopital Bretonneau, Tours

37066

Tennessee Oncology, PLLC, Gallatin

37067

Tennessee Oncology, PLLC, Franklin

Vanderbilt-Ingram Cancer Center-Cool Springs, Franklin

37076

Tennessee Oncology, PLLC, Hermitage

37087

Tennessee Oncology, PLLC, Lebanon

37130

Tennessee Oncology, PLLC, Murfreesboro

37167

Tennessee Oncology, PLLC, Smyrna

37203

Sarah Cannon Research Institute, Nashville

Tennessee Oncology, PLLC, Nashville

37205

Tennessee Oncology, PLLC, Nashville

37207

Tennessee Oncology, PLLC, Nashville

37211

Tennessee Oncology, PLLC, Nashville

37232

Vanderbilt University Medical Center, Nashville

37343

Chattanooga Oncology & Hematology Associates, Hixson

37404

Chattanooga Oncology and Hematology Associates, PC, Chattanooga

Chattanooga Oncology Hematology Associates P.C., Chattanooga

41009

Hospital Universitario Virgen Macarena, Seville

43210

Ohio State University Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus

Ohio State University, Columbus

43211

James Care in Kenny, Columbus

44060

Lake University - Ireland Cancer Center (LUICC), Mentor

44106

Case Western Reserve University, Cleveland

44122

UHHS - Chagrin Highlands, Orange

44124

Monarch, Mayfield Heights

44145

UHHS - Westlake, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44805

Centre Rene Gauducheau - Service Oncologie Medicale, Saint-Herblain

45122

Innere Klinik und Poliklinik fuer Tumorforschung, Universitaetsklinikum Essen, Essen

46032

Cental Indiana Cancer Centers, Carmel

46037

Central Indiana Cancer Centers, Fishers

46140

Cental Indiana Cancer Centers, Greenfield

46219

Central Indiana Cancer Centers, Indianapolis

46227

Central Indiana Cancer Centers, Indianapolis

48201

Karmanos Cancer Institute, Detroit

48334

Weisberg Cancer Treatment Center, Farmington Hills

50009

Hospital Universitario Miguel Servet, Zaragoza

52074

RWTH Aachen, Urologische Klinik, Aachen

52100

UOC Oncologia Medica, Ospedale San Donato, Arezzo

54511

Centre Alexis Vautrin, Vandœuvre-lès-Nancy

55131

Klinikum der Johannes-Gutenberg-Universitaet, III. Medizinische Klinik und Poliklinik, Mainz

55455

University of Minnesota Medical Center Fairview, Minneapolis

60153

Loyola University Chicago Cardinal Bernardin Cancer Center, Maywood

63090

St. John's Mercy Medical Center, Washington

63141

St. John's Mercy Medical Center, St Louis

St. John's Mercy, David C. Pratt Cancer Center, St Louis

65201

Missouri Cancer Associates, Columbia

69373

Centre Leon Berard, Lyon

75246

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

75702

Texas Oncology, P.A., Tyler

75908

Hopital Europeen Georges Pompidou, Paris

76022

Texas Oncology, P.A., Bedford

76177

Investigation Products Center (IPC), Fort Worth

Investigational Products Center (IPC), Fort Worth

US Oncology Research and Clinical Pharmacy, Fort Worth

77030

Genitourinary Cancer Center, Houston

The University of Texas MD Anderson Cancer Center, Houston

77598

Texas Oncology - Clear Lake, Webster

78613

Texas Oncology - Cedar Park, Cedar Park

78655

Texas Oncology - Seton Williamson, Round Rock

78681

Texas Oncology - Round Rock, Round Rock

78705

Texas Oncology - Austin Midtown, Austin

Texas Oncology - Central Midtown, Austin

78731

Texas Oncology - Austin Central, Austin

78745

Texas Oncology - South Austin, Austin

78758

Texas Oncolgoy - Austin North, Austin

78759

Texas Oncology - Austin Northwest, Austin

80012

Rocky Mountain Cancer Centers, Aurora

80045

University of Colorado Cancer Center, Aurora

University of Colorado Denver: Division of Medical Oncology, Aurora

80120

Rocky Mountain Cancer Centers, Littleton

80124

Rocky Mountain Cancer Centers, Lone Tree

80131

Divisione di Oncologia, AORN Antonio Cardarelli, Napoli

Istituto per lo Studio e la Cura dei Tumori Fondazione Pascale, Napoli

80138

Rocky Mountain Cancer Centers, Parker

80218

Rocky Mountain Cancer Centers, LLP, Denver

80220

Rocky Mountain Cancer Centers, Denver

80228

Rocky Mountain Cancer Centers, Lakewood

80260

Rocky Mountain Cancer Centers, Thornton

80303

Rocky Mountain Cancer Centers, Boulder

80501

Rocky Mountain Cancer Centers, Longmont

80909

Rocky Mountain Cancer Centers, Colorado Springs

81377

Ludwig-Maximilians-Universitaet Muenchen, Klinikum Grosshadern Urologische Klinik und Poliklinik, München

83301

Mountain States Tumor Institute, Twin Falls

83619

Mountain States Tumor Institute, Fruitland

83642

Mountain States Tumor Institute, Meridian

83686

Mountain States Tumor Institute, Nampa

83712

Mountain States Tumor Institute, Boise

89052

Comprehensive Cancer Centers of Nevada, Henderson

89128

Comprehensive Cancer Centers of Nevada, Las Vegas

89135

Nevada Cancer Institute, Las Vegas

89148

Comprehensive Cancer Centers of Nevada, Las Vegas

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

90017

Los Angeles Hematology/Oncology Medical Group, Los Angeles

90033

LAC-USC Medical Center, Los Angeles

USC Norris Cancer Hospital and Clinics, Los Angeles

90057

Kenmar Research Institute, Los Angeles

Metropolitan Hematology/Oncology Medical Group, Los Angeles

90095

Ronald Regan UCLA Medical Center, Los Angeles

UCLA, Los Angeles

90241

Agajanian Institute of Oncology and Hematology, Downey

90606

Agajanian Institute of Oncology and Hematology, Whittier

90640

Agajanian Institute of Oncology and Hematology, Montebello

91206

Los Angeles Hematology/Oncology Medical Group, Glendale

91505

East Valley Hematology and Oncology Medical Group, Burbank

Maurice Berkowtiz, MD, Burbank

91790

Brian LeBerthon, MD, A Medical Corporation, West Covina

94010

Hôpital Henri Mondor, Créteil

94805

Institut Gustave Roussy / Service d'Immunotherapie, Villejuif

97477

Willamette Valley Cancer Institute and Research Center, Springfield

98101

Virginia Mason Medical Center, Section of Hematology/Oncology, Seattle

98195

University of Washington Medical Center, Seattle

100021

Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing

100036

Beijing Cancer Hospital, Beijing

115478

Cancer Research Center named after N.N. Blokhin, Biotherapy Department, Moscow

Cancer Research Center named after N.N.Blokhin, Chemotherapy Department, Moscow

117997

Russian Research Center of Roentgenology and Radiology, Moscow

122002

Fortis Memorial Research Institute, Gurgaon

123060

The Main Clinical Hospital of the Ministry of Internal Affairs of Russian Federation, Moscow

125284

Moscow Research Institute of Oncology P.A. Herzen, Moscow

169610

National Cancer Centre Singapore, Singapore

198255

City Clinical Oncology Dispensary, Saint Petersburg

200127

Urology Department, Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai

210002

The Department of Medical Oncology, PLA Cancer Center, Nanjing Bayi Hospital, Nanjing

249036

Medical Radiology Research Center of the Minzdravsotsrazvitiya of Russia, Obninsk

300060

Tianjin Oncology Hospital,biology treatment department, Tianjin

302017

Bhagwan Mahaveer Cancer Hospital and Research Center, Jaipur

400012

Dept. of Medical Oncology, Tata Memorial Hospital, Mumbai

510060

Sun Yet-Sen University Cancer Center, Guangzhou

710054

Xijing Hospital, The Fourth Military Medical University, Xi'an

02114

Massachusetts General Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

48109-5948

University of Michigan Health System, Ann Arbor

07601

Hackensack University Medical Center, Hackensack

The Cancer Center at Hackensack University Medical Center - The Hillcrest Building, Hackensack

The Cancer Center at Hackensack University Medical Center, Hackensack

13210-2306

Suny Upstate Medical University, Syracuse

97401-8122

Oncology Associates of Oregon, P.C., Eugene

17033-0850

Penn State Milton S. Hershey Medical Center, Hershey

19111-2497

Fox Chase Cancer Center, Philadelphia

37232-6307

Vanderbilt-Ingram Cancer Center, Nashville

77598-4420

Deke Slayton Cancer Center, Webster

98109-1023

Seattle Cancer Care Alliance, Seattle

A-1090

Universitaets-Klinik fuer Innere Medizin I, Vienna

22260-020

Clinica Oncologistas Associados, Rio de Janeiro

90050-170

Irmandade da Santa Casa de Misericordia de Porto Alegre (ISCMPA) - Hospital Santa Rita, Porto Alegre

14784-400

Fundacao Pio XII Hospital de Cancer de Barretos, Barretos

01509-900

Fundacao Antonio Prudente, São Paulo

T2N 4N2

Tom Baker Cancer Centre, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

V1Y 5L3

British Columbia Cancer Agency - Cancer Centre for the Southern Interior, Kelowna

E1C 8X3

Dr. Leon Richard Oncology Centre, Moncton

A1B 3V6

Dr. H. Bliss Murphy Cancer Centre, St. John's

L1G 2B9

RSM Durham Regional Cancer Centre Lakeridge Health Oshawa, Oshawa

115 28

Alexandra University Hospital / Oncology Dept., Athens

540 07

"TheagenioCancer Hospital / 3rd. Dept. of Clinical Oncology", Thessaloniki

682 026

Amrita Institute of Medical Sciences, Kochi

141 008

Christian Medical College & Hospital, Ludhiana

Unknown

Oncology Department, Dublin

00144

Struttura Complessa di Oncologia Medica A, Roma

00152

Azienda Ospedaliera San Camillo Forlanini, Oncologia Medica, Padiglione Flajani, I piano, Roma

060-8638

Hokkaido University Hospital, Sapporo

0608543

Sapporo Medical University School of Medicine, Sapporo

305-8577

University of Tsukuba, Graduate School of Comprehensive Human Sciences, Department of Urology, Tsukuba

589-8511

Kinki University Hospital, Sayama

431-3192

Hamamatsu University School of Medicine, Hamamatsu

411-8777

Shizuoka Cancer Center, Sunto-gun

116-8567

Tokyo Women's Medical University Medical Center East, Department of Urology, Arakawa-ku

104-0045

National Cancer Center Hospital, Chuo-Ku

173-8610

Nihon University Itabashi Hospital, Itabashi-ku

160-8582

Keio University Hospital, Shinjuku-ku

162-8666

Tokyo Women's Medical University Hospital, Shinjuku-ku

755-8505

Yamaguchi University Hospital, Ube-shi

010-8543

Akita University Hospital, Akita

260-8717

Chiba Cancer Center, Chiba

812-8582

Kyushu University Hospital, Fukuoka

860-8556

Kumamoto University Hospital, Kumamoto

770-8503

Tokushima University, Tokushima

990-9585

Yamagata University Hospital, Yamagata

61-485

Centrum Medyczne HCP, Poznan

61-866

Wielkopolskie Centrum Onkologii im.Marii Sklodowskiej-Curie, Poznan

80-210

Wojewodzkie Centrum Onkologii, Gdansk

60 569

Klinika Onkologii, Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego, Poznan

61-545

Pracownia Tomografii Komputerowej, Poznan

00-909

Klinika Onkologii, Wojskowy Instytut Medyczny, Warsaw

50-556

Klinika Urologii i Onkologii Urologicznej, Wroclaw

812 50

Onkologicky Ustav sv. Alzbety, Bratislava

833 10

Narodny Onkologicky ustav, Bratislava

012 07

Nemocnica s poliklinikou Zilina, Žilina

410-769

National Cancer Center, Urologic Oncology Clinic, Center for Specific Organs Cancer, Goyang-si

602-715

Dong-A University Medical Center, Department of Medicine, Division of Hemato-Oncology, Busan

110-744

Seoul National University Hospital, Seoul

120-752

Severance Hospital, Seoul

135-710

Samsung Medical Center, Seoul

137-701

Catholic University of Korea, Seoul St. Mary's Hospital, Department of Oncology, Seoul

08907

Institut Catala D'Oncologia L'Hospitalet, L'Hospitalet de Llobregat

08035

Hospital Vall D¿Hebron, Barcelona

581 85

Universitetssjukhuset, Onkologiska kliniken, Linköping

901 85

Norrlands Universitetssjukhus, Onkologkliniken, Umeå

351 85

Onkologkliniken, Vaxjo

SW3 6JJ

Royal Marsden Hospital, London

HA6 2RN

Mount Vernon Cancer Centre, Northwood

CH63 4JY

Clatterbridge Centre for Oncology NHS Foundation Trust, Bebington, Wirral

B15 2TT

University of Birmingham, CRUK Institute for Cancer Studies, Birmingham

SO41 3QS

Royal Bournemouth & Poole Hospitals, Bournemouth

BS2 8ED

Bristol Haematology and Oncology Centre, Bristol

CB2 0QQ

Addenbrooke's Hospital, Cambridge

G12 0YH

The Beatson West of Scotland Cancer Centre, Glasgow

EC1A 7BE

Department of Medical Oncology, St. Bartholomew's Hospital, London

OX3 7LJ

University Department of Medical Oncology/Oxford Cancer Centre, Oxford

SM2 5PT

Royal Marsden Hospital NHS Foundation Trust, Surrey

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT00678392 - Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer | Biotech Hunter | Biotech Hunter