220
Participants
Start Date
July 17, 2008
Primary Completion Date
March 9, 2012
Study Completion Date
November 8, 2023
Placebo
Placebo matching to ocrelizumab administered as IV infision in Cycle 1 Day 1.
Ocrelizumab
Ocrelizumab 300 mg was administered in cycle 1 followed by an infusion of ocrelizumab 600 mg on Day 1. A single infusion of ocrelizumab 600 mg was administered on Day 1 of cycles 3 and 4.
Avonex
Avonex was administered weekly intramuscular injections of 30 mcg in cycle 1 Day 1.
First MHAT; Clinic of Neurology, Sofia
Shat of Cardiovascular Diseases; Clinic of Neurology, Sofia
ACIBADEM CITY CLINIC TOKUDA HOSPITAL EAD; Clinic of Neurology and Sleep Medicine, Sofia
UMHAT Tzaritza Yoanna Sofia; CLINIC OF NEUROLOGY, Sofia
CCB Medical institute, Ministry of Interior Sofia; CLINIC OF NEUROLOGY, Sofia
Military Medical Academy; Neurology, Sofia
UZ Antwerpen, Edegem
Universitätsspital Basel; Neurologie, Basel
Fletcher Allen Health Care/University of Vermont, Burlington
Aarhus Universitetshospital; Neurologisk Afd. F, Skleroseklinikken, Aarhus N
Columbia University Medical Center; The Neurological Institute of New York, New York
Clinical Center of Serbia; Institute of Neurology, Belgrade
Suny At Stony Brook; Department Of Neurology, Stony Brook
Island Neurological Associates, P.C., Plainview
St. Joseph-Krankenhaus, Berlin
Jüdisches Krankenhaus Berlin; Abteilung fur Neurologie, Berlin
CHU De Caen; Service De Neurologie Dejerine, Caen
Clinical Center Nis; Clinic for Mental Health, Niš
Instituto Biomedico De Investigacion A.C., Aguascalientes
Clinic of Neurology, Nova Sad
Vin.Reg.Psych.Hosp.N.A Yuschenko O.I., Vnmu N.A. Pyrogov; Department of Nervous Diseases, Vinnytsia
John Hopkins University, Baltimore
Asklepios Klinik Nord-Heidberg; Neurologie, Hamburg
University of Virginia - Fontain Research Park, Charlottesville
Clinical Research of Winston Salem, Winston-Salem
Hospital Ramon y Cajal; Servicio de Neurologia, Madrid
The Neurological Institute PA, Charlotte
Hospital Regional Universitario Carlos Haya; Servicio de Neurologia, Málaga
CHU De Nimes, Hopital Caremeau; Service De Neurologie Du Prof. Pierre Labauge, Nîmes
Shepherd Center; Multiple Sclerosis Center, Atlanta
Unidad de Investigacion CIMA SC, Chihuahua City
Hospital Cima Chihauhau, Chihuahua City
MS Center of Vero Beach, Vero Beach
Hopital Pellegrin-CHU de Bordeaux; Service de Neurologie, Bordeaux
Bradenton Research Center, Bradenton
Universitatsklinikum Marburg; Zentrum für Nervenheilkunde, Klinik für Psychiatrie+Psychotherapie, Marburg
Vanderbilt University Medical Center, Nashville
Hospital Universitario Virgen Macarena; Servicio de Neurologia, Seville
Ohio State University Med Ctr; MS Center, Columbus
Cleveland Clinic, Cleveland
Hospital Universitario La Fe; Unidad de Esclerosis Multiple, Valencia
Michigan Institute for Neurological Disorders, Farmington Hills
Ukr.State Inst. of Med and Social Probl. Disab; Dept of Neur and Border states, Propetrovsk
University of Chicago; Neurology, Chicago
Ams of Ukraine; Inst. of Neurology, Psychiatry & Narcology, Kharkiv
Hopital Gabriel Montpied CHU de Clermont-Ferrand; Service de Neurologie B, Clermont-Ferrand
Hospital CIMA, Sta. Engracia, Monterrey
Kansas University Medical Center, Kansas City
Baylor College of Medicine, Houston
Integra Clinical Research, Llc, San Antonio
Advanced Neurology of Colorado, LLC, Fort Collins
Phoenix Neurological Associates Ltd, Phoenix
Barrow Neurological Institute, Phoenix
University of California San Francisco, San Francisco
East Bay Physicians Med Group;Sutter East Bay Med Foundation, Berkeley
Legacy Health System; Clinical Research & Tech Ctr, Tualatin
Central Clinical Hospital #2 N.A. Semashko OAO RJHD, Moskva
Spitalul Clinic Judetean de Urgenta Targu Mures; Clinica Neurologie, Târgu Mureş
Municipal City Hospital #33; Neurology, Nizhny Novgorod
SHI Sverdlovsk Regional Clinical Hospital #1;Neurology, Yekaterinburg
Regional Multiple Sclerosis Centre b/o CC ECM Neftyanik; Neurology, Tyumen
MRC for Oncology and Neurology; Neurology, Novosibirsk
LLC Research Medical Complex Vashe Zdorovie, Kazan'
Dartmouth-Hitchcock Medical Center; Dept of Neurology, Lebanon
Uni of British Columbia Hospital; Ms Clinical Research Group, Vancouver
St. Michael'S Hospital, Toronto
McGill University; Montreal Neurological Institute; Neurological and Psychiatric, Montreal
Fakultni Nemocnice Ostrava; Klinika hematoonkologie FNO a LF OU, Ostrava
Krajska Nemocnice Pardubice Neurologicka Klinika, Pardubice
Fakultni nemocnice Motol; Neurologicka klinika, Prague
Nemocnice Teplice; Neurologicke Oddeleni - Ms Centrum, Teplice
Ospedale S.Andrea-Universita di Roma; Centro Sclerosi Multipla, Rome
Spitalul Clinic Colentina; Clinica de Neurologie, Bucharest
Fakultna Nemocnica F. D. Roosevelta; Ii. Neurologicka Klinika Szu, Banská Bystrica
Fakultna Nemocnica, Pracovisko Stare Mesto; Neurology, Bratislava
Fakultna Nemocnica Paterua, Pracovisko Trieda Snp1 Kosice; Neurologicka Klinika, Košice
Fakultna Nemocnica Nitra; Neurologicka Klinika, Nitra
Nemocnica s Poliklinikou Spisska Nova Ves, a.s., Spišská Nová Ves
Hospital Universitari Vall d'Hebron; Servicio de Neumo-Inmunologia, Barcelona
Hospital Clinic i Provincial; Servicio de Neurologia, Barcelona
City Clin.Hosp #4; Dept. of Neurology, Kyiv
Walton Centre NHS Foundation Trust, Neuroscience Research Centre; CLINICAL TRIALS UNIT, Liverpool
Uni Hospital Queens Medical Centre; Neurology, Nottingham
Royal Hallamshire Hospital; Neurology, Sheffield
Lead Sponsor
Roche Pharma AG
INDUSTRY
Genentech, Inc.
INDUSTRY