PH I SRC Kinase, Dasatinib Combo Paclitaxel & Carboplatin in Pts w Ovarian, Peritoneal, & Tubal Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

11

Participants

Timeline

Start Date

August 31, 2007

Primary Completion Date

September 30, 2011

Study Completion Date

November 30, 2012

Conditions
Ovarian CancerPeritoneal CancerFallopian Tube Cancer
Interventions
DRUG

Dasatinib, Paclitaxel, and Carboplatin

"Dasatinib will be administered as an oral dose (tablet) as per the dose escalation (50 mg everyday - 250 mg everyday)continuously on days 2-21 in the first cycle (3 weeks) therapy and continuously (days 1-21) throughout the remainder of therapy.~Paclitaxel will be administered on a 21-day schedule. Paclitaxel (150-175 mg/m\^2) IV infused over 3 hours on day #1 of each cycle.~Carboplatin (AUC=5-6 mg/,l/min) will be infused over 30-60 minutes every cycle via IV on day 1 of every cycle following the paclitaxel administration.~All patients will be followed until disease progression or study withdrawal. In addition, following disease progression, patients will be monitored for delayed toxicity and survival for a period of 5 years and data entered into eDC, unless is withdrawn."

Trial Locations (2)

27701

Duke University Health System, Durham

33612-9497

Moffitt Cancer Center, Tampa

All Listed Sponsors
lead

AA Secord

OTHER

NCT00672295 - PH I SRC Kinase, Dasatinib Combo Paclitaxel & Carboplatin in Pts w Ovarian, Peritoneal, & Tubal Cancer | Biotech Hunter | Biotech Hunter