Efficacy and Safety of Quadruple Therapy in Eradication of H. Pylori: A Comparison to Triple Therapy

PHASE3CompletedINTERVENTIONAL
Enrollment

440

Participants

Timeline

Start Date

June 30, 2008

Primary Completion Date

July 31, 2009

Study Completion Date

August 31, 2009

Conditions
Helicobacter Infections
Interventions
DRUG

Omeprazole, amoxicillin, clarithromycin

Triple therapy given for 7 days at a dose of omeprazole 20 mg BID, amoxicillin 500 mg 2 capsules BID, and clarithromycin 500 mg 1 tablet BID

DRUG

Pylera (Bismuth subcitrate potassium, metronidazole, tetracycline) given in combination with omeprazole

Pylera is a three in one capsule containing bismuth subcitrate potassium 120 mg, metronidazole 125 mg and tetracycline 125 mg given as 3 capsules QID, with omeprazole 20 mg BID.

Trial Locations (1)

Unknown

Dr. I. Orpen, Bath

Sponsors
All Listed Sponsors
lead

Forest Laboratories

INDUSTRY