66
Participants
Start Date
October 31, 2005
Primary Completion Date
August 31, 2009
Study Completion Date
December 31, 2009
S-citalopram
Participants will take 10 to 30 mg of s-citalopram daily for 12 weeks.
Cognitive behavioral therapy (CBT)
Participants will attend twice weekly CBT sessions for 2 weeks and then once weekly sessions for 10 weeks. Sessions will focus on modifying thoughts and behaviors that may contribute to depression.
TRODAT-1 single photon emission computed tomographic (SPECT) imaging
Participants' striatal dopamine transporter (DAT) levels will be measured using \[99mTc\]TRODAT-1 SPECT with magnetic resonance imaging (MRI) co-localization on two separate occasions. Participants with depression will undergo TRODAT-1 SPECT imaging immediately before and after 12 weeks of their assigned treatment. Healthy participants will undergo TRODAT-1 SPECT imaging at baseline and 12 weeks later.
Depression Research Unit - University of Pennsylvania, Philadelphia
National Institute of Mental Health (NIMH)
NIH
University of Pennsylvania
OTHER