Safety and Tolerability Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS)

PHASE2CompletedINTERVENTIONAL
Enrollment

194

Participants

Timeline

Start Date

April 9, 2008

Primary Completion Date

July 31, 2009

Study Completion Date

September 4, 2009

Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG

Placebo

Placebo: 2 tablets taken orally twice daily

DRUG

Dexpramipexole 50 mg/day

Dexpramipexole: 2 x 12.5 mg tablets taken orally twice daily

DRUG

Dexpramipexole 150 mg/day

Dexpramipexole: 2 x 37.5 mg tablets taken orally twice daily

DRUG

Dexpramipexole 300 mg/day

Dexpramipexole: 2 x 75 mg tablets taken orally twice daily

Trial Locations (21)

10032

Columbia University, Lou Gehrig MDA/ALS Research Center, New York

13210

SUNY Upstate Medical University, Syracuse

15213

University of Pittsburgh School of Medicine, Pittsburgh

17033

Penn State Hershey Medical Center, Hershey

19102

Drexel University College Of Medicine, Philadelphia

21228

Johns Hopkins University School of Medicine, Baltimore

22908

University of Virginia Health System, Charlottesville

33136

University of Miami Miller School of Medicine, Miami

37232

Vanderbilt University Medical Center, Nashville

63110

Washington University School of Medicine, St Louis

66160

University of Kansas Medical Center, Kansas City

68506

Bryan LGH Medical Center East, Lincoln

72205

University of Arkansas for Medical Sciences, Little Rock

78229

University of Texas Health Sciences Center of San Antonio, San Antonio

80045

University of Colorado Health Sciences Center, Aurora

84132

University of Utah, Salt Lake City

90095

UCLA, Dept. of Neurology - Neuromuscular/ALS Research Center, Los Angeles

94115

The Forbes Norris MDA/ALS Research Center, San Francisco

97239

Oregon Health Sciences University, Portland

98195

University of Washington, Seattle

02129

Massachusettes General Hospital, Boston

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Knopp Biosciences

INDUSTRY

NCT00647296 - Safety and Tolerability Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) | Biotech Hunter | Biotech Hunter