Allogenic Stem Cell Transplantation (SCT) With Non-myeloablative Conditioning in Patients With Relapse Non-Hodgkin's Lymphoma (NHL)

PHASE2CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

November 30, 2007

Primary Completion Date

February 21, 2011

Study Completion Date

February 4, 2013

Conditions
Non-Hodgkin Lymphoma
Interventions
DRUG

Ibritumomab Tiuxetan (Zevalin)

"Conditioning Regimen~1. Rituximab, 250 mg/m2 on days -21 and -14.~2. Ibritumomab tiuxetan (Zevalin): 0.4 mCi/kg (14.8 MBq/kg). Maximum: 32 mCi on day -14.~Chemotherapy:~* Fludarabine 30 mg/m2/day on days -7, -6, -5, -4 and -3 as a 30-min infusion.~* Melphalan 70 mg/m2/day on days -3 and -2 as a 15-min infusion.~Chemotherapy for relapsing patients after autologous transplantation including melphalan over the last 6 months:~* Thiotepa 5 mg/kg over 4 hours every 12 hours on day -8.~* Fludarabine 30 mg/m2/day on days -7, -6, -5, -4 and -3 as a 30-min infusion.~* Melphalan 70 mg/m2/day on day -2 as a 15-min infusion."

Trial Locations (14)

Unknown

H. Santa Creu i Sant Pau., Barcelona

H. U. Marqués de Valdecilla., Santander

H.U. 12 de Octubre, Madrid

H.U. Gregorio Marañón, Madrid

H.U. La Princesa, Madrid

H.U. Ramón y Cajal., Madrid

H. Morales Meseguer., Murcia

H. Virgen de la Arrixaca, Murcia

Clinica Universitaria de Navarra, Pamplona

H. Central de Asturias, Oviedo

H. Clinico de Salamanca, Salamanca

H. Clínico Valencia, Valencia

H. La Fe, Valencia

H.U. Miguel Servet, Zaragoza

All Listed Sponsors
lead

Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea

OTHER

NCT00644371 - Allogenic Stem Cell Transplantation (SCT) With Non-myeloablative Conditioning in Patients With Relapse Non-Hodgkin's Lymphoma (NHL) | Biotech Hunter | Biotech Hunter