Dose Escalation Study of Liposomal Paclitaxel With/Without Capecitabine in Patients With Advanced Gastric Carcinoma

PHASE1UnknownINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

May 31, 2008

Primary Completion Date

September 30, 2009

Study Completion Date

December 31, 2009

Conditions
Gastric Carcinoma
Interventions
DRUG

Liposomal paclitaxel and capecitabine

Patients will be given Liposomal paclitaxel intravenously in 3 hours with the dose of 175mg/m2、185mg/m2、195mg/m2、 200mg/m2、205mg/m2 and so on ,at the first day of chemotherapy. Capecitabine will be given on d1 to d14 with the dose of 185mg/m2、200mg/m2 or d8 to d21 with the dose of 175mg/m2、195mg/m2、205mg/m2 .Cycle duration will be 21 days. Each patient will receive 2 cycles of therapy. Only in the first cycle blood samples will be taken on 16 points in 48 hours after the infusion of liposomal paclitaxel.

Trial Locations (1)

100021

RECRUITING

Cancer Hospital,Chinese Academy of Medical Science, Beijing

All Listed Sponsors
lead

Nanjing Sike Pharmaceutical Co., Ltd.

INDUSTRY