Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor

PHASE1CompletedINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

February 26, 2007

Primary Completion Date

January 19, 2013

Study Completion Date

December 10, 2024

Conditions
Solid TumorAdult Central Nervous System Germ Cell TumorAdult RhabdomyosarcomaChildhood Central Nervous System Germ Cell TumorChildhood Soft Tissue SarcomaEwing SarcomaMetastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal TumorOvarian Mixed Germ Cell TumorPreviously Untreated Childhood RhabdomyosarcomaRecurrent Adult Brain TumorRecurrent Adult Soft Tissue SarcomaRecurrent Childhood Brain Stem GliomaRecurrent Childhood Cerebellar AstrocytomaRecurrent Childhood Cerebral AstrocytomaRecurrent Childhood EpendymomaRecurrent Childhood Malignant Germ Cell TumorRecurrent Childhood MedulloblastomaRecurrent Childhood PineoblastomaRecurrent Childhood Supratentorial Primitive Neuroectodermal TumorRecurrent Childhood Visual Pathway and Hypothalamic GliomaRecurrent Childhood Visual Pathway GliomaRecurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal TumorRecurrent Extragonadal Germ Cell TumorRecurrent Extragonadal Non-seminomatous Germ Cell TumorRecurrent Malignant Testicular Germ Cell TumorRecurrent NeuroblastomaRecurrent Ovarian Germ Cell TumorRecurrent Wilms Tumor and Other Childhood Kidney TumorsUnspecified Adult Solid Tumor, Protocol SpecificUnspecified Childhood Solid Tumor, Protocol Specific
Interventions
DRUG

busulfan

Given IV

DRUG

melphalan

Given IV

DRUG

topotecan hydrochloride

Given IV

OTHER

laboratory biomarker analysis

Correlative studies

BIOLOGICAL

filgrastim

Given IV or subcutaneously

PROCEDURE

autologous hematopoietic stem cell transplantation

Undergo transplantation

OTHER

pharmacological study

Correlative studies

PROCEDURE

autologous bone marrow transplantation

Undergo transplantation

Trial Locations (1)

91010

City of Hope, Duarte

All Listed Sponsors
lead

City of Hope Medical Center

OTHER

NCT00638898 - Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor | Biotech Hunter | Biotech Hunter